Casp9 Cancer Research Results

Casp9, Caspase-9: Click to Expand ⟱
Source:
Type:
Caspase-9 is the apoptotic initiator protease of the intrinsic or mitochondrial apoptotic pathway, which is activated at multi-protein activation platforms.
Caspases are divided into two groups: the initiator caspases (caspase-2, -8, -9 and -10), which are the first to be activated in response to a signal, and the executioner caspases (caspase-3, -6, and -7) that carry out the demolition phase of apoptosis.
Caspase-9:
Role: Initiator caspase in the intrinsic apoptotic pathway.
Cancers: Frequently studied in leukemia and solid tumors.
Prognosis: Reduced expression is often linked to chemoresistance and poor prognosis.
Scientific Papers found: Click to Expand⟱
2618- Ba,    Baicalein induces apoptosis by inhibiting the glutamine-mTOR metabolic pathway in lung cancer
- in-vitro, Lung, H1299 - in-vivo, Lung, A549
TumCG↓, TumCP↓, Apoptosis↑, GLUT1↓, GLS↓, mTOR↓, *toxicity∅, cl‑Casp9↓, cl‑Casp3↓, GSH↓, GlutMet↓,
3263- Lyco,    Lycopene protects against myocardial ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening
- in-vitro, Nor, H9c2 - in-vitro, Stroke, NA
*Apoptosis↓, *MMP↑, *Cyt‑c↓, *APAF1↓, *cl‑Casp9↓, *cl‑Casp3↓, *Bcl-2↑, *BAX↓, cardioP↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH↓, 1,  

Core Metabolism/Glycolysis ⓘ

GLS↓, 1,   GlutMet↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   cl‑Casp3↓, 1,   cl‑Casp9↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

mTOR↓, 1,   TumCG↓, 1,  

Migration ⓘ

TumCP↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Mitochondria & Bioenergetics ⓘ

MMP↑, 1,  

Cell Death ⓘ

APAF1↓, 1,   Apoptosis↓, 1,   BAX↓, 1,   Bcl-2↑, 1,   cl‑Casp3↓, 1,   cl‑Casp9↓, 1,   Cyt‑c↓, 1,  

Functional Outcomes ⓘ

toxicity∅, 1,  
Total Targets: 9

Scientific Paper Hit Count for: Casp9, Caspase-9
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:45  State#:2  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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