HMGB1 Cancer Research Results

HMGB1, High Mobility Group Box 1: Click to Expand ⟱
Source:
Type:
HMGB1 is a nuclear protein that plays key roles in DNA architecture and regulation of transcription; however, when released extracellularly it can act as a damage-associated molecular pattern (DAMP), influencing immune responses and affecting tumor progression.

Overexpression of HMGB1, particularly when associated with increased extracellular release, is frequently correlated with enhanced tumor aggressiveness, metastasis, and poorer survival across several cancer types including breast, colorectal, lung, ovarian, and pancreatic cancers.
• Its critical involvement in inflammation and immune modulation makes HMGB1 an attractive candidate for targeted therapeutic intervention as well as a potential prognostic marker.
Scientific Papers found: Click to Expand⟱
1601- Cu,    The copper (II) complex of salicylate phenanthroline induces immunogenic cell death of colorectal cancer cells through inducing endoplasmic reticulum stress
- in-vitro, CRC, NA
i-CRT↓, ICD↑, i-ATP↓, i-HMGB1↓, ER Stress↑, ROS↑, DCells↑, CD8+↑, IL12↑, IFN-γ↑, TGF-β↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ICD↑, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

i-ATP↓, 1,  

Protein Folding & ER Stress ⓘ

i-CRT↓, 1,   ER Stress↑, 1,  

Migration ⓘ

TGF-β↓, 1,  

Immune & Inflammatory Signaling ⓘ

DCells↑, 1,   i-HMGB1↓, 1,   IFN-γ↑, 1,   IL12↑, 1,  

Infection & Microbiome ⓘ

CD8+↑, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: HMGB1, High Mobility Group Box 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1059  State#:8  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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