EP300 Cancer Research Results

EP300, E1A binding protein p300: Click to Expand ⟱
Source: CGL-Driver Genes
Type: TSG (actually onocogene)
A transcriptional co-activator that plays a crucial role in regulating gene expression, cell growth, and differentiation. It is involved in various cellular processes, including the response to signaling pathways and the regulation of the cell cycle.
EP300 functions as a tumor suppressor in some contexts, while in others, it may promote oncogenic processes. Its role can depend on the specific type of cancer and the molecular context.
High levels may correlate with poor survival outcomes.
EP300 is a critical player in cancer biology, with its expression levels serving as potential biomarkers for prognosis in various cancers. Its role in transcriptional regulation and chromatin remodeling underscores its importance in tumorigenesis and cancer progression.

EP300 (p300) encodes a histone acetyltransferase (HAT) and transcriptional co-activator. p300 acetylates histones (e.g., H3, H4) and numerous non-histone proteins, loosening chromatin and enabling transcription. It functions as a signal integrator, translating upstream cues (growth factors, stress, hypoxia) into gene expression programs.
Key Pathways Modulated by EP300
Pathway / TF	           EP300 Effect	                Cancer Consequence
p53	                   Acetylation → activation	Tumor suppression (when intact)
MYC	                   Co-activation	        Proliferation, metabolism
HIF-1α	                   Co-activation under hypoxia	Angiogenesis, survival
NF-κB	                   Acetylation	                Inflammation, survival
Hormone receptors (ER/AR)  Co-activation	        Lineage-specific growth


Scientific Papers found: Click to Expand⟱
5793- ASA,    Aspirin Recapitulates Features of Caloric Restriction
- in-vitro, Nor, NA
*CRM↑, Altogether, these findings identify aspirin as an evolutionary conserved CRM.
*HATs↓, inhibit the acetyltransferase activity of EP300
*NF-kB↓, aspirin reportedly inhibits the activation of the pro-inflammatory transcription factor nuclear factor kappa light-chain enhancer of activated B cell (NF-κB)
*EP300↓, Salicylate Inhibits EP300 Acetyltransferase by Competing with AcCoA

415- CUR,    Curcumin inhibits proteasome activity in triple-negative breast cancer cells through regulating p300/miR-142-3p/PSMB5 axis
- vitro+vivo, BC, MDA-MB-231
PSMB5↓,
CT-I↓,
miR-142-3p↑,
EP300↓, P300

5794- Sper,    Spermidine induces autophagy by inhibiting the acetyltransferase EP300
- in-vitro, Nor, U2OS
*EP300↓, potent autophagy inducers including spermidine de facto act as EP300 inhibitors.
*mTORC1↓, simultaneously inhibit mTORC1.
*CRM↑, caloric restriction or intermediate fasting,7 continuous or intermittent medication of rapamycin,8, 9, 10 administration of the sirtuin 1-activator resveratrol,11, 12 external supply of the polyamine spermidine,
*HATs↓, Spermidine turned out to be an efficient inhibitor of histone acetyltransferases in vitro
*p62↓, Moreover, all the mentioned acetyltransferase inhibitors induced a significant reduction of p62/SQSTM1 levels,
*AntiAge↑, Spermidine retards the manifestation of several major age-associated diseases including arterial aging,36 colon cancer37 and neurodegenerative processes in mice
AntiCan↑,

5802- Sper,    Spermidine reduces cancer-related mortality in humans
- Review, Var, NA
EP300↓, Aspirin, which – like spermidine – inhibits EP300 by competing with acetyl CoA [22], is well known for its cancer-preventive action
Risk↓, cancer-preventive action [23,24] in particular on the gastrointestinal system (a 30% decrease of cancer in long-term users) [25] but also lung [26], mammary [27] and prostate carcinomas (a 10% decrease) [28].


Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

PSMB5↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

EP300↓, 2,   miR-142-3p↑, 1,  

Drug Metabolism & Resistance ⓘ

CT-I↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   Risk↓, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Core Metabolism/Glycolysis ⓘ

CRM↑, 2,  

Transcription & Epigenetics ⓘ

HATs↓, 2,  

Autophagy & Lysosomes ⓘ

p62↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

EP300↓, 2,   mTORC1↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,  
Total Targets: 7

Scientific Paper Hit Count for: EP300, E1A binding protein p300
2 Spermidine
1 Aspirin -acetylsalicylic acid
1 Curcumin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:101  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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