Smad1 Cancer Research Results

Smad1, Smad1: Click to Expand ⟱
Source:
Type:
SMAD1 is a member of the SMAD family of proteins that are key intracellular mediators of the bone morphogenetic protein (BMP) signaling pathway. BMP/SMAD signaling plays a variety of roles in cell differentiation, proliferation, apoptosis, and migration.

In some cancers, altered SMAD1 expression has been reported. For example, reduced expression can compromise the tumor-suppressive BMP signaling in some contexts, potentially allowing for unchecked cell proliferation.
In other scenarios, particularly where BMP signaling promotes tumor progression or metastasis, elevated SMAD1 might be associated with a more aggressive phenotype.

In cancers where SMAD1 functions predominantly as a tumor suppressor (via proper BMP signaling), lower levels of SMAD1 might be associated with a poorer prognosis.
Conversely, in tumors where BMP signaling contributes to invasion or metastasis, higher SMAD1 expression may correlate with aggressive disease and worse outcomes.
Scientific Papers found: Click to Expand⟱
4926- PEITC,    PEITC inhibits the invasion and migration of colorectal cancer cells by blocking TGF-β-induced EMT
- in-vitro, CRC, SW48
TumCI↓, PEITC inhibits the invasion and migration of colorectal cancer cells.
TumCMig↓,
EMT↓, PEITC suppresses the EMT of colorectal cancer cells
Smad1↓, PEITC blocks the TGF-β1/Smad signaling pathway and TGF-β1 induced EMT.
AntiCan↑, PEITC exerts remarkable anti-cancer effects in several types of cancer, such as gastric cancer [20], lung cancer [21], prostate cancer [22], melanoma [23], breast cancer [24] and CRC
Snail↓, (SNAIL1, SLUG, ZEB1 and ZEB2). As shown in the Fig. 3B, PEITC treatment downregulated the expression levels of these four genes
Slug↓,
Zeb1↓,
ZEB2↓,
TGF-β1↓, PEITC significantly decreased the levels of TGF-β1 in SW480 cells.
eff↑, A recent study demonstrated the chemopreventive role of PEITC and curcumin in prostate cancer xenografts
E-cadherin↑, PEITC was found to upregulate epithelial markers (E-cadherin) and downregulate mesenchymal markers (N-cadherin, Vimentin) of CRC cells.
N-cadherin↓,
Vim↓,

4657- RES,    Resveratrol, cancer and cancer stem cells: A review on past to future
- Review, Var, NA
CSCs↓, RSV is reported to regulate all the major CSC signaling pathways, but exact mechanisms of its interactions are not clearly understood
CD133↓, CD133(+) cells ↓
Shh↓, Sonic hedgehog (Shh) ↓
Twist↓, GBM Stem cell marker expression: Twist ↓, Snail↓, Slug ↓, MMP-2 ↓, MMP-9 ↓, Smad ↓
Snail↓,
MMP2↓,
MMP9↓,
Smad1↓,
CD44↓, CSC marker proteins: CD44, CD133, ALDH1A1, Oct-4, Nanog ↓
ALDH1A1↓,
OCT4↓,
Nanog↓,
STAT3↓, STAT3 ↓
survivin↓, Survivin, cyclin D1, Cox-2 and c-Myc ↓
cycD1/CCND1↓,
COX2↓,
cMyc↓,


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,  

Cell Death ⓘ

survivin↓, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

ALDH1A1↓, 1,   CD133↓, 1,   CD44↓, 1,   CSCs↓, 1,   EMT↓, 1,   Nanog↓, 1,   OCT4↓, 1,   Shh↓, 1,   STAT3↓, 1,  

Migration ⓘ

E-cadherin↑, 1,   MMP2↓, 1,   MMP9↓, 1,   N-cadherin↓, 1,   Slug↓, 1,   Smad1↓, 2,   Snail↓, 2,   TGF-β1↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   Twist↓, 1,   Vim↓, 1,   Zeb1↓, 1,   ZEB2↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,  
Total Targets: 29

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Smad1, Smad1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1011  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

Home Page