PKCδ Cancer Research Results

PKCδ, Protein Kinase C delta: Click to Expand ⟱
Source:
Type:
PKCδ is one of the novel isoforms of the Protein Kinase C (PKC) family, involved in regulating various cellular processes.
It participates in diverse signaling pathways influencing cell proliferation, differentiation, survival, apoptosis, and migration.

In some cancers, PKCδ is upregulated and associated with higher tumor aggressiveness, particularly when it contributes to pathways that promote cell survival and invasion.
Conversely, in other contexts, PKCδ has been reported to act as a tumor suppressor where its activation can promote apoptosis or inhibit cell proliferation.
Scientific Papers found: Click to Expand⟱
4427- AgNPs,    Silver nanoparticles induce apoptosis and G2/M arrest via PKCζ-dependent signaling in A549 lung cells
- in-vitro, Lung, A549
tumCV↓, LDH↑, TumCCA↑, BAX↑, BID↑, Bcl-2↓, PKCδ↓,
2640- Api,    Apigenin: A Promising Molecule for Cancer Prevention
- Review, Var, NA
chemoPv↑, ITGB4↓, TumCI↓, TumMeta↓, Akt↓, ERK↓, p‑JNK↓, *Inflam↓, *PKCδ↓, *MAPK↓, EGFR↓, CK2↓, TumCCA↑, CDK1↓, P53↓, P21↑, Bax:Bcl2↑, Cyt‑c↑, APAF1↑, Casp↑, cl‑PARP↑, VEGF↓, Hif1a↓, IGF-1↓, IGFBP3↑, E-cadherin↑, β-catenin/ZEB1↓, HSPs↓, Telomerase↓, FASN↓, MMPs↓, HER2/EBBR2↓, CK2↓, eff↑, AntiAg↑, eff↑, FAK↓, ROS↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, cl‑IAP2↑, AR↓, PSA↓, p‑pRB↓, p‑GSK‐3β↓, CDK4↓, ChemoSen↑, Ca+2↑, cal2↑,
3391- ART/DHA,    Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug
- Review, Var, NA
TumCP↓, TumMeta↓, angioG↓, TumVol↓, BioAv↓, Half-Life↓, BioAv↑, eff↑, eff↓, ROS↑, selectivity↑, TumCCA↑, survivin↓, BAX↑, Casp3↓, Casp8↑, Casp9↑, CDC25↓, CycB/CCNB1↓, NF-kB↓, cycD1/CCND1↓, cycE/CCNE↓, E2Fs↓, P21↑, p27↑, ADP:ATP↑, MDM2↓, VEGF↓, IL8↓, COX2↓, MMP9↓, ER Stress↓, cMyc↓, GRP78/BiP↑, DNAdam↑, AP-1↓, MMP2↓, PKCδ↓, Raf↓, ERK↓, JNK↓, PCNA↓, CDK2↓, CDK4↓, TOP2↓, uPA↓, MMP7↓, TIMP2↑, Cdc42↑, E-cadherin↑,
1148- ART/DHA,    Artemisinin inhibits extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinase-9 expression via a protein kinase Cδ/p38/extracellular signal-regulated kinase pathway in phorbol myristate acetate-induced THP-1 macrophages
- in-vitro, AML, THP1
MMP9↓, EMMPRIN↓, p‑PKCδ↓, p‑JNK↓, p‑p38↓, p‑ERK↓,
3176- Ash,    Apoptosis is induced in leishmanial cells by a novel protein kinase inhibitor withaferin A and is facilitated by apoptotic topoisomerase I-DNA complex
- in-vitro, NA, NA
PKCδ↓, TOP1∅, ROS↑, GSH↓, DNAdam↑, MMP↓, Cyt‑c↑,
5362- AV,    Anti-cancer effects of aloe-emodin: a systematic review
- Review, Var, NA
AntiCan↑, eff↝, TumCP↓, TumCMig↓, TumCI↓, TumCCA↑, TumCD↑, MMP↓, ROS↑, Apoptosis↑, CDK1↓, CycB/CCNB1↓, Bcl-2↓, PCNA↓, ATP↓, ER Stress↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, MMP2↓, Ca+2↑, DNAdam↑, Akt↓, PKCδ↓, mTORC2↓, GSH↓, ChemoSen↑,
1605- EA,    Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
- Review, Var, NA
*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑, COX2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1?, PDK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,
1621- EA,    The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, TumCI↓, TumAuto↑, VEGFR2↓, MAPK↓, PI3K↓, Akt↓, PD-1↓, NOTCH↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, CDK2↑, CDK6↓, Bcl-2↓, cl‑PARP↑, BAX↑, Casp3↑, DR4↑, DR5↑, Snail↓, MMP2↓, MMP9↓, TGF-β↑, PKCδ↓, β-catenin/ZEB1↓, SIRT1↓, HO-1↓, ROS↑, CHOP↑, Cyt‑c↑, MMP↓, OCR↓, AMPK↑, Hif1a↓, NF-kB↓, E-cadherin↑, Vim↓, EMT↓, LC3II↑, CIP2A↓, GLUT1↓, PDH↝, MAD↓, LDH↓, GSTs↑, NOTCH↓, survivin↓, XIAP↓, ER Stress↑, ChemoSideEff↓, ChemoSen↑,
5228- EMD,    Evaluating anticancer activity of emodin by enhancing antioxidant activities and affecting PKC/ADAMTS4 pathway in thioacetamide-induced hepatocellular carcinoma in rats
- in-vivo, HCC, NA
OS↑, PKCδ↓, ERK5↓, MMP3↓, VEGF↓, NRF2↑, HO-1↑, MDA↓, AFP↓,
2850- FIS,    Fisetin regulates TPA-induced breast Cancer cell invasion by suppressing matrix metalloproteinase-9 activation via the PKC/ROS/MAPK pathways
- in-vitro, BC, MCF-7
TumCI↓, PKCδ↓, ROS↓, ERK↑, p38↓, NF-kB↓, MMP9↓,
2829- FIS,    Fisetin: An anticancer perspective
- Review, Var, NA
TumCP↓, TumCI↓, TumCCA↑, TumCG↓, Apoptosis↑, cl‑PARP↑, PKCδ↓, ROS↓, ERK↓, NF-kB↓, survivin↓, ROS↑, PI3K↓, Akt↓, mTOR↓, MAPK↓, p38↓, HER2/EBBR2↓, EMT↓, PTEN↑, HO-1↑, NRF2↑, MMP2↓, MMP9↓, MMP↓, Casp8↑, Casp9↑, TRAILR↑, Cyt‑c↑, XIAP↓, P53↑, CDK2↓, CDK4↓, CDC25↓, CDC2↓, VEGF↓, DNAdam↑, TET1↓, CHOP↑, CD44↓, CD133↓, uPA↓, CSCs↓,
2830- FIS,    Biological effects and mechanisms of fisetin in cancer: a promising anti-cancer agent
- Review, Var, NA
TumCG↓, angioG↓, *ROS↓, TumCMig↓, VEGF↓, MAPK↑, NF-kB↓, PI3K↓, Akt↓, mTOR↓, NRF2↑, HO-1↑, ROS↓, Inflam↓, ER Stress↑, ROS↑, TumCP↓, ChemoSen↑, PTEN↑, P53↑, Casp3↑, Casp8↑, Casp9↑, COX2↓, Wnt↓, EGFR↓, Mcl-1↓, survivin↓, IAP1↓, IAP2↓, PGE2↓, β-catenin/ZEB1↓, DR5↑, MMP2↓, MMP9↓, FAK↓, uPA↓, EMT↓, ERK↓, JNK↑, p38↑, PKCδ↓, BioAv↓, BioAv↑, BioAv↑,
1787- LE,    Licorice and cancer
- Review, Var, NA
Inflam↓, AntiCan↓, DNAdam↓, LOX1↓, COX2↓, PKCδ↓, EGFR↓,
2906- LT,    Luteolin, a flavonoid with potentials for cancer prevention and therapy
- Review, Var, NA
*Inflam↓, AntiCan↑, antiOx⇅, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, PI3K↓, Akt↓, NF-kB↓, XIAP↓, P53↑, *ROS↓, *GSTA1↑, *GSR↑, *SOD↑, *Catalase↑, *other↓, ROS↑, Dose↝, chemoP↑, NF-kB↓, JNK↑, p27↑, P21↑, DR5↑, Casp↑, Fas↑, BAX↑, MAPK↓, CDK2↓, IGF-1↓, PDGF↓, EGFR↓, PKCδ↓, TOP1↓, TOP2↓, Bcl-xL↓, FASN↓, VEGF↓, VEGFR2↓, MMP9↓, Hif1a↓, FAK↓, MMP1↓, Twist↓, ERK↓, P450↓, CYP1A1↓, CYP1A2↓, TumCCA↑,
2243- MF,    Pulsed electromagnetic fields increase osteogenetic commitment of MSCs via the mTOR pathway in TNF-α mediated inflammatory conditions: an in-vitro study
- in-vitro, Nor, NA
*eff↑, *mTOR↑, *Akt↑, *PKA↑, *MAPK↑, *ERK↑, *BMP2↑, *Diff↑, *PKCδ↓, *VEGF↑, *IL10↑,
4918- PEITC,    Nutritional Sources and Anticancer Potential of Phenethyl Isothiocyanate: Molecular Mechanisms and Therapeutic Insights
- Review, Var, NA
Apoptosis↑, TumCP↓, angioG↓, TumMeta↓, NF-kB↓, Akt↓, MAPK↓, *BioAv↓, ROS↑, lipid-P↑, AIF↑, Cyt‑c↑, DR4↑, DR5↑, TumCCA↑, JAK↓, STAT3↓, MMP2↓, MMP9↓, PKCδ↓, Hif1a↓, JNK↓, Mcl-1↓, COX2↓, MMP↓, Casp3↑, ChemoSen↑, *BioAv↓, Half-Life↓,
5187- PEITC,    Phenethyl Isothiocyanate Inhibits Migration and Invasion of Human Gastric Cancer AGS Cells through Suppressing MAPK and NF-κB Signal Pathways
- in-vitro, GC, AGS
TumMeta↓, ERK↓, MKK7↓, PKCδ↓, Rho↓, uPA↓, MMP2↓, MMP9↓, RAS↓, VEGF↓, FAK↓, iNOS↓, COX2↓, TumCP↓,
3347- QC,    Recent Advances in Potential Health Benefits of Quercetin
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *Inflam↓, TumCP↓, Apoptosis↑, *cardioP↑, *BP↓, TumMeta↓, MDR1↓, NADPH↓, ChemoSen↑, MMPs↓, TIMP2↑, *NLRP3↓, *IFN-γ↑, *COX2↓, *NF-kB↓, *MAPK↓, *CRP↓, *IL6↓, *TNF-α↓, *IL1β↓, *TLR4↑, *PKCδ↓, *AP-1↓, *ICAM-1↓, *NRF2↑, *HO-1↑, *lipid-P↓, *neuroP↑, *eff↑, *memory↑, *cognitive↑, *AChE↓, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑,
3343- QC,    Quercetin, a Flavonoid with Great Pharmacological Capacity
- Review, Var, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, eff↑, P-gp↓, eff↑, eff↑, eff↑, eff↑, CycB/CCNB1↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,
3368- QC,    The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiCan↑, Casp3↓, p‑Akt↓, p‑mTOR↓, p‑ERK↓, β-catenin/ZEB1↓, Hif1a↓, AntiAg↓, VEGFR2↓, EMT↓, EGFR↓, MMP2↓, MMP↓, TumMeta↓, MMPs↓, Akt↓, Snail↓, N-cadherin↓, Vim↓, E-cadherin↑, STAT3↓, TGF-β↓, ROS↓, P53↑, BAX↑, PKCδ↓, PI3K↓, COX2↓, cFLIP↓, cycD1/CCND1↓, cMyc↓, IL6↓, IL10↓, Cyt‑c↑, TumCCA↑, DNMTs↓, HDAC↓, ac‑H3↑, ac‑H4↑, Diablo↑, Casp3↑, Casp9↑, PARP1↑, eff↑, PTEN↑, VEGF↓, NO↓, iNOS↓, ChemoSen↑, eff↑, eff↑, eff↑, uPA↓, CXCR4↓, CXCL12↓, CLDN2↓, CDK6↓, MMP9↓, TSP-1↑, Ki-67↓, PCNA↓, ROS↑, ER Stress↑,
3952- Taur,    Taurine and Astrocytes: A Homeostatic and Neuroprotective Relationship
- Review, AD, NA - Review, Stroke, NA
*antiOx↑, *Inflam↓, *Ca+2↓, *neuroP↑, *other↑, *Dose↝, *PKCδ↓, *VGCC↓, *GABA↑,
5904- TV,    Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Obesity, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *Inflam↓, *Bacteria↓, AntiTum↑, IronCh↑, *HDL↑, *LDL↓, *BioAv↝, *Half-Life↝, *BioAv↑, *SOD↑, *GPx↑, *GSTs↑, *eff↑, radioP↑, *MDA↓, *other↑, *COX1↓, *COX2↓, *AntiAg↑, *RNS↓, *NO↓, *H2O2↓, *NOS2↓, *NADH↓, *Imm↑, Apoptosis↑, TumCP↓, angioG↓, TumCMig↓, Ca+2↑, TumCCA↑, DNAdam↑, BAX↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, AIF↑, i-ROS↑, MMP↓, Cyt‑c↑, APAF1↑, Ca+2↑, MMP9↓, MMP2↓, PKCδ↓, ERK↓, H2O2↑, BAX↑, Bcl-2↓, DNAdam↑, lipid-P↑, ChemoSen↑, chemoP↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *BP↓, *AntiDiabetic↑, *Obesity↓, RenoP↑, *GastroP↑, hepatoP↑, *AChE↓, *cognitive↑, *BChE↓, *other↓, *BioAv↑,
2281- VitK2,    The biological responses of vitamin K2: A comprehensive review
- Review, Var, NA
*ROS↓, *12LOX↓, *NF-kB↓, *BMD↑, *hepatoP↑, cycD1/CCND1↓, PKCδ↓, STAT3↓, ERK↑, MAPK↓, ROS↑, PI3K↝, Akt↝, Hif1a↝, *neuroP↑,
1830- VitK2,    Vitamin K Intake and Risk of Lung Cancer: The Japan Collaborative Cohort Study
- Study, Lung, NA
Risk↓, NF-kB↓, PKCδ↓,
1211- VitK2,    Mechanisms of PKC-Mediated Enhancement of HIF-1α Activity and its Inhibition by Vitamin K2 in Hepatocellular Carcinoma Cells
- in-vitro, HCC, HUH7
Hif1a↓, PKCδ↓,

Showing Research Papers: 1 to 25 of 25

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 25

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx⇅, 1,   CYP1A1↓, 1,   GSH↓, 2,   GSTs↑, 1,   H2O2↑, 1,   HO-1↓, 2,   HO-1↑, 3,   HO-2↓, 1,   lipid-P↑, 2,   MAD↓, 1,   MDA↓, 1,   NRF2↑, 3,   ROS↓, 5,   ROS↑, 12,   i-ROS↑, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics ⓘ

ADP:ATP↑, 1,   AIF↑, 3,   ATP↓, 1,   CDC2↓, 1,   CDC25↓, 2,   MKK7↓, 1,   MMP↓, 9,   OCR↓, 1,   Raf↓, 1,   XIAP↓, 4,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   cMyc↓, 4,   ECAR↝, 1,   FASN↓, 2,   GlucoseCon↓, 1,   Glycolysis↓, 1,   lactateProd↓, 1,   LDH↓, 1,   LDH↑, 1,   NADPH↓, 1,   PDH↝, 1,   PDK1?, 2,   SIRT1↓, 2,  

Cell Death ⓘ

Akt↓, 8,   Akt↑, 1,   Akt↝, 1,   p‑Akt↓, 2,   APAF1↑, 2,   Apoptosis↑, 8,   BAX↓, 1,   BAX↑, 7,   Bax:Bcl2↑, 2,   Bcl-2↓, 5,   Bcl-xL↓, 2,   BID↑, 1,   Casp↑, 2,   Casp3↓, 2,   Casp3↑, 6,   cl‑Casp3↑, 2,   cl‑Casp7↑, 1,   Casp8↑, 4,   cl‑Casp8↑, 1,   Casp9↑, 6,   cl‑Casp9↑, 2,   cFLIP↓, 1,   CK2↓, 2,   Cyt‑c↑, 10,   Diablo↑, 2,   DR4↑, 2,   DR5↑, 4,   Fas↑, 1,   IAP1↓, 1,   IAP2↓, 1,   cl‑IAP2↑, 1,   iNOS↓, 3,   JNK↓, 2,   JNK↑, 2,   p‑JNK↓, 2,   MAPK↓, 5,   MAPK↑, 1,   Mcl-1↓, 3,   MDM2↓, 3,   Myc↓, 1,   NOXA↑, 1,   p27↑, 2,   p38↓, 2,   p38↑, 1,   p‑p38↓, 1,   PUMA↑, 1,   survivin↓, 5,   Telomerase↓, 2,   TRAILR↑, 1,   TumCD↑, 1,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 2,  

Transcription & Epigenetics ⓘ

ac‑H3↑, 1,   ac‑H4↑, 1,   p‑pRB↓, 1,   tumCV↓, 3,  

Protein Folding & ER Stress ⓘ

CHOP↑, 2,   ER Stress↓, 1,   ER Stress↑, 4,   GRP78/BiP↑, 1,   HSP70/HSPA5↓, 1,   HSP90↓, 1,   HSPs↓, 1,  

Autophagy & Lysosomes ⓘ

LC3II↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 2,   DNAdam↑, 6,   DNMTs↓, 1,   P53↓, 1,   P53↑, 5,   cl‑PARP↑, 7,   PARP1↑, 1,   PCNA↓, 4,   SIRT6↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 3,   CDK2↓, 5,   CDK2↑, 1,   CDK4↓, 4,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 5,   cycE/CCNE↓, 2,   E2Fs↓, 1,   P21↑, 4,   p‑RB1↓, 1,   TumCCA↑, 11,  

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 1,   CD44↓, 1,   CDK8↓, 1,   CIP2A↓, 1,   CSCs↓, 1,   EMT↓, 4,   ERK↓, 8,   ERK↑, 2,   p‑ERK↓, 3,   ERK5↓, 1,   p‑GSK‐3β↓, 1,   HDAC↓, 1,   IGF-1↓, 2,   IGFBP3↑, 1,   mTOR↓, 2,   p‑mTOR↓, 1,   mTORC2↓, 1,   NOTCH↓, 3,   PI3K↓, 5,   PI3K↝, 1,   PTEN↑, 4,   RAS↓, 2,   STAT3↓, 4,   p‑STAT3↓, 1,   TOP1↓, 1,   TOP1∅, 1,   TOP2↓, 3,   TumCG↓, 2,   Wnt↓, 1,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

AntiAg↓, 1,   AntiAg↑, 1,   AP-1↓, 1,   Ca+2↑, 4,   Ca+2↝, 1,   cal2↑, 1,   Cdc42↑, 1,   CLDN2↓, 1,   CXCL12↓, 1,   E-cadherin↑, 4,   EMMPRIN↓, 1,   FAK↓, 4,   p‑FAK↓, 1,   ITGB4↓, 1,   Ki-67↓, 2,   KRAS↓, 1,   MMP1↓, 1,   MMP2↓, 10,   MMP3↓, 1,   MMP7↓, 1,   MMP9↓, 12,   MMPs↓, 3,   N-cadherin↓, 1,   PDGF↓, 1,   PKCδ↓, 20,   p‑PKCδ↓, 1,   Rho↓, 1,   SMAD3↓, 1,   Snail↓, 3,   TET1↓, 1,   TGF-β↓, 2,   TGF-β↑, 1,   TIMP2↑, 2,   TSP-1↑, 1,   TumCI↓, 5,   TumCMig↓, 3,   TumCP↓, 11,   TumMeta↓, 8,   Twist↓, 2,   uPA↓, 5,   Vim↓, 2,   β-catenin/ZEB1↓, 4,  

Angiogenesis & Vasculature ⓘ

angioG↓, 6,   EGFR↓, 6,   Endoglin↑, 1,   Hif1a↓, 7,   Hif1a↝, 1,   LOX1↓, 1,   NO↓, 1,   VEGF↓, 9,   VEGFR2↓, 3,  

Barriers & Transport ⓘ

GLUT1↓, 1,   NHE1↓, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 7,   CXCR4↓, 1,   IL10↓, 1,   IL6↓, 1,   IL8↓, 1,   Inflam↓, 3,   JAK↓, 2,   NF-kB↓, 10,   PD-1↓, 1,   PD-L1↓, 1,   PGE2↓, 1,   PSA↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CDK6↓, 4,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 3,   ChemoSen↑, 8,   CYP1A2↓, 1,   Dose↝, 2,   Dose∅, 1,   eff↓, 1,   eff↑, 15,   eff↝, 1,   Half-Life↓, 2,   MDR1↓, 1,   P450↓, 1,   RadioS↑, 2,   selectivity↑, 3,  

Clinical Biomarkers ⓘ

AFP↓, 1,   AR↓, 1,   EGFR↓, 6,   HER2/EBBR2↓, 2,   IL6↓, 1,   Ki-67↓, 2,   KRAS↓, 1,   LDH↓, 1,   LDH↑, 1,   Myc↓, 1,   PD-L1↓, 1,   PSA↓, 1,  

Functional Outcomes ⓘ

AntiCan↓, 1,   AntiCan↑, 3,   AntiTum↑, 1,   chemoP↑, 2,   chemoPv↑, 1,   ChemoSideEff↓, 1,   hepatoP↑, 1,   OS↑, 1,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 1,   TumVol↓, 1,  
Total Targets: 261

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 5,   Catalase↑, 3,   GPx↑, 2,   GSH↑, 2,   GSR↑, 1,   GSTA1↑, 1,   GSTs↑, 1,   H2O2↓, 1,   HDL↑, 1,   HO-1↑, 2,   lipid-P↓, 1,   MDA↓, 1,   NADH↓, 1,   Nrf1↑, 1,   NRF2↑, 2,   RNS↓, 1,   ROS↓, 6,   SOD↑, 4,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 1,   LDL↓, 1,  

Cell Death ⓘ

Akt↑, 1,   BMP2↑, 1,   MAPK↓, 2,   MAPK↑, 1,  

Transcription & Epigenetics ⓘ

other↓, 2,   other↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

Diff↑, 1,   ERK↑, 1,   GSK‐3β↓, 1,   mTOR↑, 1,   VGCC↓, 1,  

Migration ⓘ

AntiAg↑, 1,   AP-1↓, 1,   Ca+2↓, 1,   PKA↑, 1,   PKCδ↓, 4,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   NO↓, 1,   VEGF↑, 1,  

Barriers & Transport ⓘ

GastroP↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 3,   CRP↓, 1,   ICAM-1↓, 1,   IFN-γ↑, 1,   IL10↓, 1,   IL10↑, 1,   IL17↓, 1,   IL1β↓, 2,   IL6↓, 1,   Imm↑, 1,   Inflam↓, 7,   MCP1↓, 1,   NF-kB↓, 2,   TLR4↑, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission ⓘ

AChE↓, 2,   BChE↓, 1,   GABA↑, 1,   tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,   NLRP3↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 4,   BioAv↑, 7,   BioAv↝, 1,   Dose↝, 1,   eff↑, 3,   Half-Life↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers ⓘ

BMD↑, 1,   BP↓, 3,   CRP↓, 1,   IL6↓, 1,   NOS2↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 1,   cardioP↑, 3,   cognitive↑, 2,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 4,   Obesity↓, 1,   Pain↓, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 84

Scientific Paper Hit Count for: PKCδ, Protein Kinase C delta
3 Fisetin
3 Quercetin
3 Vitamin K2
2 Artemisinin
2 Ellagic acid
2 Phenethyl isothiocyanate
1 Silver-NanoParticles
1 Apigenin (mainly Parsley)
1 Ashwagandha(Withaferin A)
1 Aloe anthraquinones
1 Emodin
1 Licorice
1 Luteolin
1 Magnetic Fields
1 Taurine
1 Thymol-Thymus vulgaris
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1021  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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