ER Stress Cancer Research Results

ER Stress, endoplasmic reticulum (ER) stress signaling pathway: Click to Expand ⟱
Source:
Type:
Protein expression of ATF, GRP78, and GADD153 which is a hall marker of ER stress.
The endoplasmic reticulum (ER) stress signaling pathway plays a crucial role in maintaining cellular homeostasis and responding to various stressors, including those encountered in cancer. When cells experience stress, such as the accumulation of misfolded proteins, they activate a series of signaling pathways collectively known as the unfolded protein response (UPR). The UPR aims to restore normal function by enhancing the protein-folding capacity of the ER, degrading misfolded proteins, and, if the stress is unresolved, triggering apoptosis.
The activation of ER stress pathways can contribute to resistance against chemotherapy and targeted therapies. Cancer cells may utilize the UPR to survive treatment-induced stress, making it challenging to achieve effective therapeutic outcomes.

-ER stress-associated proteins include: phosphorylation of PERK, eIF2α, ATF4, CHOP and cleaved-caspase 12
Scientific Papers found: Click to Expand⟱
2657- AL,    Allicin pharmacology: Common molecular mechanisms against neuroinflammation and cardiovascular diseases
- Review, CardioV, NA - Review, AD, NA
*Inflam↓, *antiOx↑, *neuroP↑, *cardioP↑, *AntiTum↑, *mtDam↑, *HSP70/HSPA5↑, *NRF2↑, *RAAS↓, *cognitive↑, *SOD↑, *ROS↓, *NRF2↑, *ER Stress↓, *neuroP↑, *memory↑, *TBARS↓, *MPO↓, *SOD↑, *GSH↑, *iNOS↓, *p‑eNOS↑, *HO-1↑,
2637- Api,    Apigenin Alleviates Endoplasmic Reticulum Stress-Mediated Apoptosis in INS-1 β-Cells
- in-vitro, Diabetic, NA
*other↝, *Insulin↑, ER Stress↓, *CHOP↓, *cl‑Casp3↓, *ROS↓, *Inflam↓, *TXNIP↓,
3391- ART/DHA,    Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug
- Review, Var, NA
TumCP↓, TumMeta↓, angioG↓, TumVol↓, BioAv↓, Half-Life↓, BioAv↑, eff↑, eff↓, ROS↑, selectivity↑, TumCCA↑, survivin↓, BAX↑, Casp3↓, Casp8↑, Casp9↑, CDC25↓, CycB/CCNB1↓, NF-kB↓, cycD1/CCND1↓, cycE/CCNE↓, E2Fs↓, P21↑, p27↑, ADP:ATP↑, MDM2↓, VEGF↓, IL8↓, COX2↓, MMP9↓, ER Stress↓, cMyc↓, GRP78/BiP↑, DNAdam↑, AP-1↓, MMP2↓, PKCδ↓, Raf↓, ERK↓, JNK↓, PCNA↓, CDK2↓, CDK4↓, TOP2↓, uPA↓, MMP7↓, TIMP2↑, Cdc42↑, E-cadherin↑,
2675- BBR,    The therapeutic effects of berberine against different diseases: A review on the involvement of the endoplasmic reticulum stress
- Review, Var, NA
*Inflam↓, *antiOx↑, *ER Stress↓, *cardioP↑, *RenoP↑, *hepatoP↑,
2676- BBR,    Berberine protects rat heart from ischemia/reperfusion injury via activating JAK2/STAT3 signaling and attenuating endoplasmic reticulum stress
- in-vivo, Nor, NA - in-vivo, CardioV, NA
*cardioP↑, *ROS↓, *ER Stress↓, *p‑PERK↓, *p‑eIF2α↓, *ATF4↓, CHOP↓, *JAK2↑, *STAT3↑, *UPR↓,
2677- BBR,    Liposome-Encapsulated Berberine Alleviates Liver Injury in Type 2 Diabetes via Promoting AMPK/mTOR-Mediated Autophagy and Reducing ER Stress: Morphometric and Immunohistochemical Scoring
- in-vivo, Diabetic, NA
*hepatoP↑, *LC3II↑, *Beclin-1↑, *AMPK↑, *mTOR↑, *ER Stress↓, *CHOP↓, *JNK↓, *ROS↓, *Inflam↓, *BG↓, *SOD↑, *GPx↑, *Catalase↑, *IL10↑, *IL6↓, *TNF-α↓, *ALAT↓, *AST↓, *ALP↓,
2679- BBR,    Berberine Improves Behavioral and Cognitive Deficits in a Mouse Model of Alzheimer’s Disease via Regulation of β-Amyloid Production and Endoplasmic Reticulum Stress
- in-vivo, AD, NA
*cognitive↑, PERK↓, *eIF2α↓, *neuroP↑, *ER Stress↓, *ROS↓,
2683- BBR,    Berberine reduces endoplasmic reticulum stress and improves insulin signal transduction in Hep G2 cells
- in-vitro, Liver, HepG2
JNK↓, p‑PERK↓, p‑eIF2α↓, *ER Stress↓,
3681- BBR,    The efficacy and mechanism of berberine in improving aging-related cognitive dysfunction: A study based on network pharmacology
- in-vivo, AD, NA
*memory↑, *cognitive↑, MAPK↑, *Akt↑, *PI3K↑, *TP53↑, *Jun↓, *HSP90↑, *neuroP↑, *Inflam↓, *antiOx↑, *p16↓, *ER Stress↓,
3695- BM,    Bacopa monnieri (L.) wettst. Extract protects against glutamate toxicity and increases the longevity of Caenorhabditis elegans
- in-vitro, AD, HT22
*OS↑, *mt-ROS↓, *ROS↓, *neuroP↑, *ER Stress↓,
5952- Cela,    Celastrol attenuates Alzheimer’s disease-mediated learning and memory impairment by inhibiting endoplasmic reticulum stress-induced inflammation and oxidative stress
- in-vivo, AD, NA
*memory↑, *Inflam↓, *ROS↓, *ER Stress↓, *neuroP↑, *Dose↝, *MDA↓, *SOD↑, *Catalase↑, *Aβ↓, BACE↓, LRP1↑, RAGE↓,
3890- Cin,    The Therapeutic Roles of Cinnamaldehyde against Cardiovascular Diseases
- Review, NA, NA
*cardioP↑, *Inflam↓, *ROS↓, *lipid-P↓, *AntiAg↑, *angioG↑, *GutMicro↑, *ER Stress↓,
3997- CoQ10,    Coenzyme Q and Its Role in the Dietary Therapy against Aging
- Review, AD, NA
*AntiAge↑, *Inflam↓, *antiOx↑, *Apoptosis↓, *BioAv↑, *other↝, *cognitive↑, *DNAdam↓, *ER Stress↓,
3627- Cro,    The effects of Crocus sativus (saffron) and its constituents on nervous system: A review
- Review, AD, NA - Review, Stroke, NA
*other↑, *monoA↑, *Aβ↓, *AChE↓, *cognitive↑, *neuroP↑, *lipid-P↓, *SOD↑, *ROS↓, *GPx↑, *MDA↓, *memory↑, *antiOx↑, *Inflam↓, *other↓, *ER Stress↓,
3832- Cro,    Traditional Chinese Medicine: Role in Reducing β-Amyloid, Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *memory↑, *Apoptosis↓, *cognitive↑, *ER Stress↓,
3206- EGCG,    Insights on the involvement of (-)-epigallocatechin gallate in ER stress-mediated apoptosis in age-related macular degeneration
- Review, AMD, NA
*Ca+2↓, *ROS↓, *Apoptosis↓, *GRP78/BiP↓, *CHOP↓, *PERK↓, *IRE1↓, *p‑PARP↓, *Casp3↓, *Casp12↓, *ER Stress↓, *UPR↓,
1323- EMD,    Anticancer action of naturally occurring emodin for the controlling of cervical cancer
- Review, Cerv, NA
TumCCA↑, DNAdam↑, mTOR↓, Casp3↑, Casp8↑, Casp9↑, TGF-β↑, SMAD3↓, p‑SMAD4↓, ROS↑, MMP↓, CXCR4↓, HER2/EBBR2↓, ER Stress↓, TumAuto↑, NOTCH1↓,
3716- FA,    Ferulic Acid as a Protective Antioxidant of Human Intestinal Epithelial Cells
- in-vitro, IBD, NA - in-vivo, NA, NA
*antiOx↑, *Inflam↓, *ER Stress↓, *other↑, *angioG↑, *Hif1a↑, *VEGF↑, *NO↓, *SIRT1↑, *PERK↓, *ATF4↓, *CHOP↓, *GutMicro↑,
2514- H2,    Hydrogen: A Novel Option in Human Disease Treatment
- Review, NA, NA
*Inflam↓, *IL1β↓, *IL6↓, *IL8↓, *IL10↓, *TNF-α↓, *ROS↓, *HO-1↓, *NRF2↑, *ER Stress↓, H2O2↑,
2507- H2,    Hydrogen protects against chronic intermittent hypoxia induced renal dysfunction by promoting autophagy and alleviating apoptosis
- in-vivo, NA, NA
*RenoP↑, *ROS↓, *Apoptosis↓, *ER Stress↓, *CHOP↓, *Casp12↓, *GRP78/BiP↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *Beclin-1↑, *p62↓, *mTOR↓,
3769- H2S,    Research progress of hydrogen sulfide in Alzheimer's disease from laboratory to hospital: a narrative review
- Review, AD, NA
*APP↓, *Apoptosis↓, *Inflam↓, *antiOx↑, *BP↓, *NLRP3↓, *ROS↓, *Aβ↓, *ER Stress↓,
2921- LT,    Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies
- Review, Nor, NA
*hepatoP↑, *AMPK↑, *SIRT1↑, *ROS↓, STAT3↓, TNF-α↓, NF-kB↓, *IL2↓, *IFN-γ↓, *GSH↑, *SREBP1↓, *ZO-1↑, *TLR4↓, BAX↑, Bcl-2↓, XIAP↓, Fas↑, Casp8↑, Beclin-1↑, *TXNIP↓, *Casp1↓, *IL1β↓, *IL18↓, *NLRP3↓, *MDA↓, *SOD↑, *NRF2↑, *ER Stress↓, *ALAT↓, *AST↓, *iNOS↓, *IL6↓, *HO-1↑, *NQO1↑, *PPARα↑, *ATF4↓, *CHOP↓, *Inflam↓, *antiOx↑, *GutMicro↑,
4231- Lut,    Luteolin and its antidepressant properties: From mechanism of action to potential therapeutic application
- Review, AD, NA
*PSD95↑, *BDNF↑, *SOD↑, *GSTA1↑, *MDA↑, *Casp3↓, *Mood↑, *antiOx↑, *Apoptosis↓, *Inflam↓, *ER Stress↓,
3261- Lyco,    Lycopene and Vascular Health
- Review, Stroke, NA
*Inflam↓, *antiOx↑, *AntiAg↑, *cardioP↑, *SOD↑, *Catalase↑, *ROS↓, *mtDam↓, *cardioP↑, *NF-kB↓, *NO↓, *COX2↓, *LDL↓, *eff↑, *ER Stress↓, *BioAv↑, *eff↑, *MMPs↓, *COX2↓, *RAGE↓,
3459- MF,    EFFECT OF PULSED ELECTROMAGNETIC FIELDS ON ENDOPLASMIC RETICULUM STRESS
- in-vitro, Cerv, HeLa
GRP78/BiP↑, GRP94↑, CHOP↑, ER Stress↓,
2053- PB,    4-Phenyl butyric acid prevents glucocorticoid-induced osteoblast apoptosis by attenuating endoplasmic reticulum stress
- in-vitro, ostP, 3T3
*ER Stress↓, *mtDam↓, *Apoptosis↓, eff↑,
2052- PB,    Lipid-regulating properties of butyric acid and 4-phenylbutyric acid: Molecular mechanisms and therapeutic applications
- Review, NA, NA
*HDAC↓, *Half-Life↑, *Half-Life↑, *lipoGen↓, *ER Stress↓, *FAO↑, *ROS↓, *BioAv↑,
2051- PB,    Beneficial Effects of Sodium Phenylbutyrate Administration during Infection with Salmonella enterica Serovar Typhimurium
- in-vivo, Inf, NA
*Inf↓, *GutMicro↑, *IL17↑, *Inflam↓, *ER Stress↓, *ROS↓, *OS↑, *Bacteria↓, *Neut↑, *toxicity↓,
2056- PB,    Endoplasmic Reticulum Stress Induces ROS Production and Activates NLRP3 Inflammasome Via the PERK-CHOP Signaling Pathway in Dry Eye Disease
- in-vitro, Nor, HCE-2
*ROS↓, *NLRP3↓, *IL1β↓, *TXNIP↑, *ER Stress↓,
2057- PB,    Trichomonas vaginalis induces apoptosis via ROS and ER stress response through ER–mitochondria crosstalk in SiHa cells
- in-vitro, Cerv, SiHa
ROS↓, tumCV∅, cl‑PARP↓, cl‑Casp3↓, MMP∅, ER Stress↓,
2058- PB,    Induction of Human-Lung-Cancer-A549-Cell Apoptosis by 4-Hydroperoxy-2-decenoic Acid Ethyl Ester through Intracellular ROS Accumulation and the Induction of Proapoptotic CHOP Expression
- in-vitro, Lung, A549
ER Stress↓,
2048- PB,    Sodium Phenylbutyrate Inhibits Tumor Growth and the Epithelial-Mesenchymal Transition of Oral Squamous Cell Carcinoma In Vitro and In Vivo
- in-vitro, OS, CAL27 - in-vitro, Oral, HSC3 - in-vitro, OS, SCC4 - in-vivo, NA, NA
*NH3↓, *HDAC↓, *ER Stress↓, Apoptosis?, Bcl-2↓, cl‑Casp3↑, TGF-β↑, N-cadherin↓, E-cadherin↑, TumVol↓, eff↑,
2028- PB,    Potential of Phenylbutyrate as Adjuvant Chemotherapy: An Overview of Cellular and Molecular Anticancer Mechanisms
- Review, Var, NA
HDAC↓, TumCCA↑, P21↑, Dose↝, Telomerase↓, IGFBP3↑, p‑p38↑, JNK↑, ERK↑, BAX↑, Casp3↑, Bcl-2↓, Cyt‑c↝, FAK↓, survivin↓, VEGF↓, angioG↓, DNArepair↓, TumMeta↓, HSP27↑, ASK1↑, ROS↑, eff↑, ER Stress↓, GRP78/BiP↓, CHOP↑, AR↓, other?,
2034- PB,    Protective effects of 4-phenylbutyrate derivatives on the neuronal cell death and endoplasmic reticulum stress
- in-vitro, Nor, SH-SY5Y
*ER Stress↓, *ChemChap↓, *cytoP↑, *cellD↓, *neuroP↑,
2041- PB,    The Effect of Glucose Concentration and Sodium Phenylbutyrate Treatment on Mitochondrial Bioenergetics and ER Stress in 3T3-L1 Adipocytes
- in-vitro, Nor, 3T3
*mitResp↓, *ER Stress↓, MMP↓, GlucoseCon↓, OCR↓, CHOP↑,
2651- PLB,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
ROS↑, TrxR↓, GSR↓, ER Stress↓, TumCCA↑, MMP↓, NF-kB↓, PI3K↓, Akt↓, mTOR↓, MKP1↓, MKP2↓, ChemoSen↑,
4297- QC,    Quercetin attenuates tau hyperphosphorylation and improves cognitive disorder via suppression of ER stress in a manner dependent on AMPK pathway
- in-vitro, AD, SH-SY5Y
*AMPK↑, *IRE1↓, *p‑PERK↓, *p‑tau↓, *cognitive↑, *antiOx↑, *ER Stress↓, *Inflam↓, *neuroP↑, *TXNIP↓, *NLRP3↓,
3337- QC,    Endoplasmic Reticulum Stress-Relieving Effect of Quercetin in Thapsigargin-Treated Hepatocytes
- in-vitro, NA, HepG2
*Inflam↓, *UPR↓, *GRP58↓, *XBP-1↓, *ER Stress↓, *antiOx↑, TNF-α↓, p‑eIF2α↓, p‑IRE1↓, p‑JNK↓, CHOP↓,
3361- QC,    Quercetin ameliorates testosterone secretion disorder by inhibiting endoplasmic reticulum stress through the miR-1306-5p/HSD17B7 axis in diabetic rats
- in-vivo, Nor, NA - in-vitro, NA, NA
*BG↓, *ROS↓, *SOD↑, *MDA↓, *ER Stress↓, *iNOS↓, *CHOP↓, *GRP78/BiP↓, *antiOx↓, *Inflam↓, *JAK2↑, *STAT3?,
3363- QC,    The Protective Effect of Quercetin on Endothelial Cells Injured by Hypoxia and Reoxygenation
- in-vitro, Nor, HBMECs
*Apoptosis↓, *angioG↑, *NRF2↑, *Keap1↓, *ATF6↓, *GRP78/BiP↓, *CLDN5↑, *ZO-1↑, *MMP↑, *BBB↑, *ROS↓, *ER Stress↓,
3365- QC,    Quercetin attenuates sepsis-induced acute lung injury via suppressing oxidative stress-mediated ER stress through activation of SIRT1/AMPK pathways
- in-vivo, Sepsis, NA
*ER Stress↓, *PDI↓, *CHOP↓, *GRP78/BiP↓, *ATF6↓, *PERK↓, *IRE1↓, *MMP↑, *SOD↑, *ROS↓, *MDA↓, *SIRT1↑, *AMPK↑, *Sepsis↓,
3366- QC,    Quercetin Attenuates Endoplasmic Reticulum Stress and Apoptosis in TNBS-Induced Colitis by Inhibiting the Glucose Regulatory Protein 78 Activation
- in-vivo, IBD, NA
*Apoptosis↓, *Inflam↓, *ROS↓, *ER Stress↓, *TNF-α↓, *MPO↓, *p‑JNK↓, *Casp12↓, *GRP78/BiP↓, *antiOx↑, *NF-kB↓,
3020- RosA,    Protective Effect of Rosmarinic Acid on Endotoxin-Induced Neuronal Damage Through Modulating GRP78/PERK/MANF Pathway
- in-vivo, Nor, NA - in-vitro, NA, SH-SY5Y
*cognitive↑, *PERK↓, *GRP78/BiP↓, *ER Stress↓,
3023- RosA,    Rosmarinic acid alleviates septic acute respiratory distress syndrome in mice by suppressing the bronchial epithelial RAS-mediated ferroptosis
- in-vivo, Sepsis, NA
*GPx4↑, *Inflam↓, *ER Stress↓, *Ferroptosis↓, *Sepsis↓, *GRP78/BiP↓, *IRE1↓, JNK↓,
3025- RosA,    Rosmarinic acid alleviates intestinal inflammatory damage and inhibits endoplasmic reticulum stress and smooth muscle contraction abnormalities in intestinal tissues by regulating gut microbiota
- in-vivo, IBD, NA
*GutMicro↑, *ROCK1↓, *Rho↓, *CaMKII ↓, *Zeb1↓, *ZO-1↓, *E-cadherin↓, *IL1β↓, *IL6↓, *TNF-α↓, *GRP78/BiP↓, *PERK↓, *IRE1↓, *ATF6↓, *CHOP↓, *Casp12↓, *Casp9↓, *BAX↓, *Casp3↓, *Cyt‑c↓, *RIP1↓, *MLKL↓, *IL10↑, *Bcl-2↑, *ER Stress↓,
3180- SFN,    Exploring the therapeutic effects of sulforaphane: an in-depth review on endoplasmic reticulum stress modulation across different disease contexts
- Review, Var, NA
*cardioP↑, *ER Stress↓, GRP78/BiP↑, XBP-1↑, Apoptosis↑, *NRF2↑, UPR↑,
2217- SK,    Shikonin Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis to Attenuate Renal Ischemia/Reperfusion Injury by Activating the Sirt1/Nrf2/HO-1 Pathway
- in-vivo, Nor, NA - in-vitro, Nor, HK-2
*ER Stress↓, *SIRT1↑, *NRF2↑, *HO-1↑, *eff↓, *RenoP↑, *GRP78/BiP↓, *CHOP↓, *Casp12↓, *BAX↓, *cl‑Casp3↓,
3950- Taur,    Taurine Supplementation as a Neuroprotective Strategy upon Brain Dysfunction in Metabolic Syndrome and Diabetes
- Review, Diabetic, NA - Review, Stroke, NA - Review, AD, NA
*Ca+2↝, *neuroP↑, *other↝, *pH↝, *ROS∅, eff↑, *MMP↑, *Apoptosis↓, *other↝, *ER Stress↓, *Bcl-xL↓, *BAX↑, *Cyt‑c↑, *cal2↓, *Casp3↓, *UPR↓, *other↝, *NF-kB↓, *NRF2↑, *GLUT1↑, *GLUT3↑, *memory↑,
3146- VitC,    Vitamin C protects against hypoxia, inflammation, and ER stress in primary human preadipocytes and adipocytes
- in-vivo, Nor, NA
*Obesity↓, *ER Stress↓, *Inflam↓, Hif1a↓, VEGF↓, GLUT1↓, GRP78/BiP↓,
3147- VitC,    Vitamin C modulates the metabolic and cytokine profiles, alleviates hepatic endoplasmic reticulum stress, and increases the life span of Gulo−/− mice
- in-vivo, Nor, NA
*OS↑, *ER Stress↓, *GRP78/BiP↓,

Showing Research Papers: 1 to 50 of 53
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 53

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSR↓, 1,   H2O2↑, 1,   ROS↓, 1,   ROS↑, 4,   TrxR↓, 1,  

Mitochondria & Bioenergetics ⓘ

ADP:ATP↑, 1,   CDC25↓, 1,   MMP↓, 3,   MMP∅, 1,   OCR↓, 1,   Raf↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,   GlucoseCon↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis?, 1,   Apoptosis↑, 1,   ASK1↑, 1,   BAX↑, 3,   Bcl-2↓, 3,   Casp3↓, 1,   Casp3↑, 2,   cl‑Casp3↓, 1,   cl‑Casp3↑, 1,   Casp8↑, 3,   Casp9↑, 2,   Cyt‑c↝, 1,   Fas↑, 1,   JNK↓, 3,   JNK↑, 1,   p‑JNK↓, 1,   MAPK↑, 1,   MDM2↓, 1,   MKP1↓, 1,   MKP2↓, 1,   p27↑, 1,   p‑p38↑, 1,   survivin↓, 2,   Telomerase↓, 1,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 1,  

Transcription & Epigenetics ⓘ

other?, 1,   tumCV∅, 1,  

Protein Folding & ER Stress ⓘ

CHOP↓, 2,   CHOP↑, 3,   p‑eIF2α↓, 2,   ER Stress↓, 8,   GRP78/BiP↓, 2,   GRP78/BiP↑, 3,   GRP94↑, 1,   HSP27↑, 1,   p‑IRE1↓, 1,   PERK↓, 1,   p‑PERK↓, 1,   UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 2,   DNArepair↓, 1,   cl‑PARP↓, 1,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   CDK4↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   E2Fs↓, 1,   P21↑, 2,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   ERK↑, 1,   HDAC↓, 1,   IGFBP3↑, 1,   mTOR↓, 2,   NOTCH1↓, 1,   PI3K↓, 1,   STAT3↓, 1,   TOP2↓, 1,  

Migration ⓘ

AP-1↓, 1,   Cdc42↑, 1,   E-cadherin↑, 2,   FAK↓, 1,   LRP1↑, 1,   MMP2↓, 1,   MMP7↓, 1,   MMP9↓, 1,   N-cadherin↓, 1,   PKCδ↓, 1,   RAGE↓, 1,   SMAD3↓, 1,   p‑SMAD4↓, 1,   TGF-β↑, 2,   TIMP2↑, 1,   TumCP↓, 1,   TumMeta↓, 2,   uPA↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   Hif1a↓, 1,   VEGF↓, 3,  

Barriers & Transport ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   CXCR4↓, 1,   IL8↓, 1,   NF-kB↓, 3,   TNF-α↓, 2,  

Protein Aggregation ⓘ

BACE↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   ChemoSen↑, 1,   Dose↝, 1,   eff↓, 1,   eff↑, 5,   Half-Life↓, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

AR↓, 1,   HER2/EBBR2↓, 1,   RAGE↓, 1,  

Functional Outcomes ⓘ

TumVol↓, 2,  
Total Targets: 119

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 13,   Catalase↑, 3,   Ferroptosis↓, 1,   GPx↑, 2,   GPx4↑, 1,   GSH↑, 2,   GSTA1↑, 1,   HO-1↓, 1,   HO-1↑, 3,   Keap1↓, 1,   lipid-P↓, 2,   MDA↓, 5,   MDA↑, 1,   MPO↓, 2,   NQO1↑, 1,   NRF2↑, 8,   ROS↓, 22,   ROS∅, 1,   mt-ROS↓, 1,   SOD↑, 10,   TBARS↓, 1,  

Mitochondria & Bioenergetics ⓘ

Insulin↑, 1,   mitResp↓, 1,   MMP↑, 3,   mtDam↓, 2,   mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 2,   AMPK↑, 4,   FAO↑, 1,   LDL↓, 1,   lipoGen↓, 1,   NH3↓, 1,   PPARα↑, 1,   SIRT1↑, 4,   SREBP1↓, 1,  

Cell Death ⓘ

Akt↑, 1,   Apoptosis↓, 10,   BAX↓, 2,   BAX↑, 1,   Bcl-2↑, 1,   Bcl-xL↓, 1,   Casp1↓, 1,   Casp12↓, 5,   Casp3↓, 4,   cl‑Casp3↓, 2,   Casp9↓, 1,   cellD↓, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 1,   Ferroptosis↓, 1,   GRP58↓, 1,   iNOS↓, 3,   JNK↓, 1,   p‑JNK↓, 1,   MLKL↓, 1,   RIP1↓, 1,  

Kinase & Signal Transduction ⓘ

CaMKII ↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,   other↑, 2,   other↝, 5,  

Protein Folding & ER Stress ⓘ

ATF6↓, 3,   ChemChap↓, 1,   CHOP↓, 10,   eIF2α↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 42,   GRP78/BiP↓, 11,   HSP70/HSPA5↑, 1,   HSP90↑, 1,   IRE1↓, 5,   PERK↓, 5,   p‑PERK↓, 2,   UPR↓, 4,   XBP-1↓, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 1,   p62↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,   p16↓, 1,   p‑PARP↓, 1,   TP53↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 2,   Jun↓, 1,   mTOR↓, 1,   mTOR↑, 1,   PI3K↑, 1,   STAT3?, 1,   STAT3↑, 1,  

Migration ⓘ

AntiAg↑, 2,   APP↓, 1,   Ca+2↓, 1,   Ca+2↝, 1,   cal2↓, 1,   E-cadherin↓, 1,   MMPs↓, 1,   RAGE↓, 1,   Rho↓, 1,   ROCK1↓, 1,   TXNIP↓, 3,   TXNIP↑, 1,   Zeb1↓, 1,   ZO-1↓, 1,   ZO-1↑, 2,  

Angiogenesis & Vasculature ⓘ

angioG↑, 3,   ATF4↓, 3,   CLDN5↑, 1,   p‑eNOS↑, 1,   Hif1a↑, 1,   NO↓, 2,   PDI↓, 1,   VEGF↑, 1,  

Barriers & Transport ⓘ

BBB↑, 1,   GLUT1↑, 1,   GLUT3↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   IFN-γ↓, 1,   IL10↓, 1,   IL10↑, 2,   IL17↑, 1,   IL18↓, 1,   IL1β↓, 4,   IL2↓, 1,   IL6↓, 4,   IL8↓, 1,   Inflam↓, 22,   JAK2↑, 2,   Neut↑, 1,   NF-kB↓, 3,   TLR4↓, 1,   TNF-α↓, 4,  

Cellular Microenvironment ⓘ

pH↝, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   BDNF↑, 1,   monoA↑, 1,   PSD95↑, 1,   p‑tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 3,   NLRP3↓, 4,  

Hormonal & Nuclear Receptors ⓘ

RAAS↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 3,   Dose↝, 1,   eff↓, 1,   eff↑, 2,   Half-Life↑, 2,  

Clinical Biomarkers ⓘ

ALAT↓, 2,   ALP↓, 1,   AST↓, 2,   BG↓, 2,   BP↓, 1,   GutMicro↑, 5,   IL6↓, 4,   RAGE↓, 1,   TP53↑, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   AntiTum↑, 1,   cardioP↑, 7,   cognitive↑, 8,   cytoP↑, 1,   hepatoP↑, 3,   memory↑, 6,   Mood↑, 1,   neuroP↑, 11,   Obesity↓, 1,   OS↑, 3,   RenoP↑, 3,   toxicity↓, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,   Inf↓, 1,   Sepsis↓, 2,  
Total Targets: 171

Scientific Paper Hit Count for: ER Stress, endoplasmic reticulum (ER) stress signaling pathway
10 Phenylbutyrate
6 Berberine
6 Quercetin
4 Vitamin C (Ascorbic Acid)
3 Rosmarinic acid
2 Crocetin
2 Hydrogen Gas
1 Allicin (mainly Garlic)
1 Apigenin (mainly Parsley)
1 Artemisinin
1 Bacopa monnieri
1 Celastrol
1 Cinnamon
1 Coenzyme Q10
1 EGCG (Epigallocatechin Gallate)
1 Emodin
1 Ferulic acid
1 hydrogen sulfide
1 Luteolin
1 Lutein
1 Lycopene
1 Magnetic Fields
1 Plumbagin
1 Sulforaphane (mainly Broccoli)
1 Shikonin
1 Taurine
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:103  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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