RIP3 Cancer Research Results

RIP3, Receptor‐Interacting Protein Kinase 3: Click to Expand ⟱
Source:
Type:
RIP3 Receptor‐Interacting Protein Kinase 3
Several cancers have decreased RIP3 expression and is associated with poorer prognosis, more aggressive tumor behavior, and resistance to chemotherapies. Restoration of RIP3 may promote necroptosis, providing a potential mechanism to overcome therapy resistance.
Scientific Papers found: Click to Expand⟱
2355- SK,    Pharmacological properties and derivatives of shikonin-A review in recent years
- Review, Var, NA
AntiCan↑, TumCP↓, TumCMig↓, Apoptosis↑, TumAuto↑, Necroptosis↑, ROS↑, TrxR1↓, PKM2↓, RIP1↓, RIP3↓, Src↓, FAK↓, PI3K↓, Akt↓, mTOR↓, GRP58↓, MMPs↓, ATF2↓, cl‑PARP↑, Casp3↑, p‑p38↑, p‑JNK↑, p‑ERK↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,   TrxR1↓, 1,  

Core Metabolism/Glycolysis ⓘ

PKM2↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,   ATF2↓, 1,   Casp3↑, 1,   GRP58↓, 1,   p‑JNK↑, 1,   Necroptosis↑, 1,   p‑p38↑, 1,   RIP1↓, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

DNA Damage & Repair ⓘ

cl‑PARP↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↓, 1,   mTOR↓, 1,   PI3K↓, 1,   Src↓, 1,  

Migration ⓘ

FAK↓, 1,   MMPs↓, 1,   RIP3↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,  
Total Targets: 24

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: RIP3, Receptor‐Interacting Protein Kinase 3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1066  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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