CD14 Cancer Research Results

CD14, CD14: Click to Expand ⟱
Source:
Type:
CD14 is a co-receptor that recognizes several ligands, including bacterial lipopolysaccharide (LPS) and other pathogen-associated molecular patterns (PAMPs). It plays a pivotal role in innate immunity by identifying danger signals.
CD14 works in close cooperation with Toll-like receptors (TLRs), especially TLR4.

CD14 is highly expressed in myeloid cells within the tumor microenvironment, such as tumor-associated macrophages (TAMs) and certain dendritic cell subsets.
A high prevalence of CD14⁺ cells within the tumor microenvironment is associated with chronic inflammation, which in turn can contribute to tumor progression, angiogenesis, and eventual metastasis.
Scientific Papers found: Click to Expand⟱
1841- dietFMD,    Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer
- Trial, Var, NA
BG↓, In 101 patients, the FMD was safe, feasible, and resulted in a consistent decrease of blood glucose and growth factor concentration
AntiCan↑, mediate fasting/FMD anticancer effects in preclinical experiments
IFN-γ↑, enrichment of IFNγ
eff↑, Cyclic FMD Is Safe in Combination with Standard Anticancer Treatments
Dose↝, five-day FMD followed by 16 to 23 days of refeeding
CD14↓, end of five-day FMD, we found a significant decrease of total monocytes (CD14+)
IGF-1↓, Preclinical evidence in tumor-bearing mice suggests that fasting/FMD-induced reduction of blood glucose and insulin/IGF1 concentration
IGFR↓, induced reduction of serum IGF1 levels is associated with the downregulation of total and activated IGF1R at the tumor level
CD8+↑, where five-day fasting/FMD in patients with breast cancer increased total and activated intratumor CD8+ T cells, aDCs, NK cells, and Tem cells,
NK cell↑,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State ⓘ

IGF-1↓, 1,   IGFR↓, 1,  

Immune & Inflammatory Signaling ⓘ

CD14↓, 1,   IFN-γ↑, 1,   NK cell↑, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   eff↑, 1,  

Clinical Biomarkers ⓘ

BG↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,  

Infection & Microbiome ⓘ

CD8+↑, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CD14, CD14
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1068  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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