ChemoSen Cancer Research Results

ChemoSen, chemo-sensitization: Click to Expand ⟱
Source:
Type:
The effectiveness of chemotherapy by increasing cancer cell sensitivity to the drugs used to treat them, which is known as “chemo-sensitization”.

Chemo-Sensitizers:
-Curcumin
-Resveratrol
-EGCG
-Quercetin
-Genistein
-Berberine
-Piperine: alkaloid from black pepper
-Ginsenosides: active components of ginseng
-Silymarin
-Allicin
-Lycopene
-Ellagic acid
-caffeic acid phenethyl ester
-flavopiridol
-oleandrin
-ursolic acid
-butein
-betulinic acid
Scientific Papers found: Click to Expand⟱
2424- 2DG,  SRF,    The combination of the glycolysis inhibitor 2-DG and sorafenib can be effective against sorafenib-tolerant persister cancer cells
- in-vitro, HCC, Hep3B - in-vitro, HCC, HUH7
ChemoSen↓, Glycolysis↓, HK1↓, HK2↓, ATP↓,
2647- AL,    The Mechanism in Gastric Cancer Chemoprevention by Allicin
- Review, GC, NA
ChemoSen↓, TumCG↓, TumCCA↑, ER Stress↑, Apoptosis↑, Casp↑, DR5↑,
4758- antiOx,  Chemo,    Therapeutic controversies over use of antioxidant supplements during cancer treatment: a scoping review
- Review, Var, NA
ChemoSen↓, other↝, other↝,
4746- antiOx,  Chemo,  VitA,RetA,  VitC,  Se  Using Supplements During Chemo: Yes or No?
- Review, Var, NA
eff↓, ChemoSen↓, RadioS↓, other↝,
1385- BBR,  5-FU,    Low-Dose Berberine Attenuates the Anti-Breast Cancer Activity of Chemotherapeutic Agents via Induction of Autophagy and Antioxidation
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
eff↓, ROS↑, TumCP↑, NRF2↑, ChemoSen↓,
5762- CAPE,    Caffeic acid phenethyl ester promotes oxaliplatin sensitization in colon cancer by inhibiting autophagy
- in-vitro, CRC, SW480 - in-vitro, CRC, HCT116
ChemoSen↓, Apoptosis↑,
4775- CoQ10,  Chemo,    Chemotherapy induces an increase in coenzyme Q10 levels in cancer cell lines
- in-vitro, Var, NA
ChemoSen↓, *antiOx↑, *lipid-P?,
2263- dietMet,    Methionine Restriction and Cancer Biology
- Review, Var, NA
AntiCan↑, TumCP↓, TumCG↓, selectivity↑, ChemoSen↓, RadioS↑, Insulin↓, *GlucoseCon↑, *ROS↓, *antiOx↑, *GSH↑, GSH↑, eff↑, polyA↓, TS↓, Raf↓, Akt↓, Casp9↑, Bak↑, P21↑, p27↑, Insulin↓, IGF-1↓,
2914- LT,    Therapeutic Potential of Luteolin on Cancer
- Review, Var, NA
*antiOx↑, *IronCh↑, *toxicity↓, *BioAv↓, *BioAv↑, DNAdam↑, TumCP↓, DR5↑, P53↑, JNK↑, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, survivin↓, cycD1/CCND1↓, CycB/CCNB1↓, CDC2↓, P21↑, angioG↓, MMP2↓, AEG1↓, VEGF↓, VEGFR2↓, MMP9↓, CXCR4↓, PI3K↓, Akt↓, ERK↓, TumAuto↑, LC3B-II↑, EMT↓, E-cadherin↑, N-cadherin↓, Wnt↓, ROS↑, NICD↓, p‑GSK‐3β↓, iNOS↓, COX2↓, NRF2↑, Ca+2↑, ChemoSen↑, ChemoSen↓, IFN-γ↓, RadioS↑, MDM2↓, NOTCH1↓, AR↓, TIMP1↑, TIMP2↑, ER Stress↑, CDK2↓, Telomerase↓, p‑NF-kB↑, p‑cMyc↑, hTERT/TERT↓, RAS↓, YAP/TEAD↓, TAZ↓, NF-kB↓, NRF2↓, HO-1↓, MDR1↓,
3273- Lyco,    Lycopene
- Review, Var, NA
antiOx↑, ChemoSen↓, RadioS↓,
5607- NaHCO3,    Does Baking Soda Function as a Magic Bullet for Patients With Cancer? A Mini Review
- Review, Var, NA
AntiCan↑, e-pH↑, TumMeta↓, TumCI↓, TumCG↓, CD8+↑, NK cell↑, Remission↑, eff↑, ChemoSen↑, ChemoSen↓,
1672- PBG,    The Potential Use of Propolis as an Adjunctive Therapy in Breast Cancers
- Review, BC, NA
ChemoSen↓, RadioS↑, Inflam↓, AntiCan↑, Dose∅, mtDam↑, Apoptosis?, OCR↓, ATP↓, ROS↑, ROS↑, LDH↓, TP53↓, Casp3↓, BAX↓, P21↓, ROS↑, eNOS↑, iNOS↑, eff↑, hTERT/TERT↓, cycD1/CCND1↓, eff↑, eff↑, eff↑, eff↑, STAT3↓, TIMP1↓, IL4↓, IL10↓, OS↑, Dose∅, ER Stress↑, ROS↑, NF-kB↓, p65↓, MMP↓, TumAuto↑, LC3II↑, p62↓, TLR4↓, mtDam↑, LDH↓, ROS↑, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDH↓, IL10↓, HDAC8↓, eff↑, eff↑, P21↑,
2122- TQ,    Review on Molecular and Therapeutic Potential of Thymoquinone in Cancer
- Review, Var, NA
ChemoSen↓, *ROS↓, *GSH↑, RenoP↑, hepatoP↑, COX2↓, NF-kB↓, chemoPv↑, neuroP↑, TumCCA↑, P21↑, p27↑, ROS↑, DNAdam↑, MUC4↓,
4847- Uro,    Metabolite of ellagitannins, urolithin A induces autophagy and inhibits metastasis in human sw620 colorectal cancer cells
- in-vitro, CRC, SW-620
TumCP↓, TumCMig↓, MMP9↓, TumAuto↑, Apoptosis↑, TumCCA↓, TumMeta↓, ChemoSen↓,
1817- VitK2,    Research progress on the anticancer effects of vitamin K2
- Review, Var, NA
TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumCG↓, ChemoSen↓, ChemoSideEff↓, toxicity∅, eff↑, cycD1/CCND1↓, CDK4↓, eff↑, IKKα↓, NF-kB↓, other↑, p27↑, cMyc↓, i-ROS↑, Bcl-2↓, BAX↑, p38↑, MMP↓, Casp9↑, p‑ERK↓, RAS↓, MAPK↓, p‑P53↑, Casp8↑, Casp3↑, cJun↑, MMPs↓, eff↑, eff↑,

Showing Research Papers: 1 to 15 of 15

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 15

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   GSH↑, 1,   HK1↓, 1,   HO-1↓, 1,   NRF2↓, 1,   NRF2↑, 2,   ROS↑, 8,   i-ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 2,   CDC2↓, 1,   Insulin↓, 2,   MMP↓, 2,   mtDam↑, 2,   OCR↓, 1,   Raf↓, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,   p‑cMyc↑, 1,   Glycolysis↓, 2,   HK2↓, 2,   LDH↓, 3,   PFK↓, 1,   PKM2↓, 1,   polyA↓, 1,   TS↓, 1,  

Cell Death ⓘ

Akt↓, 2,   Apoptosis?, 1,   Apoptosis↑, 4,   Bak↑, 1,   BAX↓, 1,   BAX↑, 2,   Bcl-2↓, 1,   Casp↑, 1,   Casp3↓, 1,   Casp3↑, 1,   cl‑Casp3↑, 1,   Casp8↑, 1,   cl‑Casp8↑, 1,   Casp9↑, 2,   cl‑Casp9↑, 1,   DR5↑, 2,   hTERT/TERT↓, 2,   iNOS↓, 1,   iNOS↑, 1,   JNK↑, 1,   MAPK↓, 1,   MDM2↓, 1,   NICD↓, 1,   p27↑, 3,   p38↑, 1,   survivin↓, 1,   Telomerase↓, 1,   YAP/TEAD↓, 1,  

Transcription & Epigenetics ⓘ

cJun↑, 1,   other↑, 1,   other↝, 3,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 3,  

Autophagy & Lysosomes ⓘ

LC3B-II↑, 1,   LC3II↑, 1,   p62↓, 1,   TumAuto↑, 4,  

DNA Damage & Repair ⓘ

DNAdam↑, 2,   P53↑, 1,   p‑P53↑, 1,   cl‑PARP↑, 1,   TP53↓, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   CDK4↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 3,   P21↓, 1,   P21↑, 4,   TumCCA↓, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   ERK↓, 1,   p‑ERK↓, 1,   p‑GSK‐3β↓, 1,   HDAC8↓, 1,   IGF-1↓, 1,   NOTCH1↓, 1,   PI3K↓, 1,   RAS↓, 2,   STAT3↓, 1,   TAZ↓, 1,   TumCG↓, 4,   Wnt↓, 1,  

Migration ⓘ

AEG1↓, 1,   Ca+2↑, 1,   E-cadherin↑, 1,   MMP2↓, 1,   MMP9↓, 2,   MMPs↓, 1,   MUC4↓, 1,   N-cadherin↓, 1,   TIMP1↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   TumCP↓, 3,   TumCP↑, 1,   TumMeta↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   eNOS↑, 1,   VEGF↓, 1,   VEGFR2↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   CXCR4↓, 1,   IFN-γ↓, 1,   IKKα↓, 1,   IL10↓, 2,   IL4↓, 1,   Inflam↓, 1,   NF-kB↓, 4,   p‑NF-kB↑, 1,   NK cell↑, 1,   p65↓, 1,   TLR4↓, 1,  

Cellular Microenvironment ⓘ

e-pH↑, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↓, 15,   ChemoSen↑, 2,   Dose∅, 2,   eff↓, 2,   eff↑, 13,   MDR1↓, 1,   RadioS↓, 2,   RadioS↑, 3,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

AR↓, 1,   hTERT/TERT↓, 2,   LDH↓, 3,   TP53↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 3,   chemoPv↑, 1,   ChemoSideEff↓, 1,   hepatoP↑, 1,   neuroP↑, 1,   OS↑, 1,   Remission↑, 1,   RenoP↑, 1,   toxicity∅, 1,  

Infection & Microbiome ⓘ

CD8+↑, 1,  
Total Targets: 143

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 3,   GSH↑, 2,   lipid-P?, 1,   ROS↓, 2,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Core Metabolism/Glycolysis ⓘ

GlucoseCon↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,  

Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 9

Scientific Paper Hit Count for: ChemoSen, chemo-sensitization
3 Chemotherapy
2 Anti-oxidants
1 2-DeoxyGlucose
1 Sorafenib (brand name Nexavar)
1 Allicin (mainly Garlic)
1 Vitamin A, Retinoic Acid
1 Vitamin C (Ascorbic Acid)
1 Selenium
1 Berberine
1 5-fluorouracil
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Coenzyme Q10
1 diet Methionine-Restricted Diet
1 Luteolin
1 Lycopene
1 Bicarbonate(Sodium)
1 Propolis -bee glue
1 Thymoquinone
1 Urolithin
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1106  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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