SK Cancer Research Results

SK, Sphingosine kinases: Click to Expand ⟱
Source:
Type:
Sphingosine kinases (commonly abbreviated as SK, with SK1 and SK2 being the main isoforms) are enzymes that catalyze the phosphorylation of sphingosine to produce sphingosine-1-phosphate (S1P).
S1P is a bioactive signaling lipid that regulates cell growth, survival, migration, and angiogenesis. Elevated levels of S1P can promote proliferation and inhibit apoptosis (programmed cell death).
-In many types of cancer, SK (especially SK1) is found to be overexpressed, leading to increased production of S1P. This can contribute to tumor growth, metastasis, and resistance to chemotherapy.
Scientific Papers found: Click to Expand⟱
1515- EGCG,  Phen,    Reciprocal Relationship Between Cytosolic NADH and ENOX2 Inhibition Triggers Sphingolipid-Induced Apoptosis in HeLa Cells
- in-vitro, Cerv, HeLa - in-vitro, Nor, MCF10 - in-vitro, BC, BT20
selectivity↑, ENOX2 INHIBITORS SLOW THE GROWTH OF HeLa CELLS AND INDUCE APOPTOSIS IN CANCER BUT NOT IN NON-CANCER CELLS
ENOX2↓,
NADH↑, INCREASED NADH RESULTING FROM ENOX2 CELL SURFACE INHIBITION INHIBITS PLASMA MEMBRANE-ASSOCIATED SPHINGOSINE KINASE (SK) AND LOWERS LEVELS OF PRO-SURVIVAL SPHINGOSINE-1-PHOSPHATE (S1P
SK↓, SK activity was decreased in response to 1.5 mM NADH
eff↑, Capsaicin added to block NADH oxidation by endo- genous ENOX2 was without effect when added alone but enhanced inhibition slightly when combined with 1.5 mM NADH
aSmase↑, SMase activity was stimulated by NADH


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ENOX2↓, 1,   NADH↑, 1,  

Cell Death ⓘ

aSmase↑, 1,   SK↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,   selectivity↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: SK, Sphingosine kinases
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1122  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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