Pyro Cancer Research Results

Pyro, Pyroptosis: Click to Expand ⟱
Source:
Type:
Pyroptosis is a form of programmed cell death characterized by the formation of membrane pores by gasdermin proteins, leading to cell swelling, lysis, and the release of inflammatory mediators.
Scientific Papers found: Click to Expand⟱
3265- Lyco,    Lycopene inhibits pyroptosis of endothelial progenitor cells induced by ox-LDL through the AMPK/mTOR/NLRP3 pathway
- in-vitro, Nor, NA
*AMPK↑, through the activation of AMPK, which led to the inhibition of mTOR phosphorylation and subsequent downregulation of the downstream NLRP3 inflammasome.
*mTOR↓,
*NLRP3↓,
*Pyro↓, Suppression of pyroptosis in EPCs by lycopene

6422- QC,    Quercetin Protects Ethanol-Induced Hepatocyte Pyroptosis via Scavenging Mitochondrial ROS and Promoting PGC-1α-Regulated Mitochondrial Homeostasis in L02 Cells
- in-vitro, Alcohol, L02
*mt-ROS↓, quercetin treatment downregulated redox status, lipid droplets, and LPO release, restored damaged mitochondrial membrane potential, and repaired mtDNA damage, PGC-1α nuclear transfer, and mitochondrial dynamics.
*lipid-P↓,
*MMP↑,
*mtDam↓,
*NLRP3↓, gene and protein expressions of NLRP3, ASC, cleaved-caspase1, IL-18, IL-1β, and GSDMD-N were decreased, which effectively inhibited cell pyroptosis.
*ASC↓,
*cl‑Casp1↓,
*IL18↓,
*IL1β↓,
*GSDMD↓,
*Pyro↓,
*CYP2E1↓, Quercetin Inhibited CYP2E1 Activity to Alleviate High-Concentration Ethanol-Induced Hepatocyte Oxidative Stress and Lipid Peroxidation
*MFN1↓, Our study found that quercetin inhibited the expressions of mitochondrial fusion genes including Mfn1, Mfn2, and OPA1,
*MFN2↓,
*OPA1↓,
*DRP1/DNM1L↑, as well as increased fission genes expressions, and and the most significant change was Drp1


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

DRP1/DNM1L↑, 1,   MFN1↓, 1,   MFN2↓, 1,   OPA1↓, 1,  

Redox & Oxidative Stress ⓘ

CYP2E1↓, 1,   lipid-P↓, 1,   mt-ROS↓, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,   mtDam↓, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,  

Cell Death ⓘ

cl‑Casp1↓, 1,   GSDMD↓, 1,   Pyro↓, 2,  

Proliferation, Differentiation & Cell State ⓘ

mTOR↓, 1,  

Immune & Inflammatory Signaling ⓘ

ASC↓, 1,   IL18↓, 1,   IL1β↓, 1,  

Protein Aggregation ⓘ

NLRP3↓, 2,  
Total Targets: 18

Scientific Paper Hit Count for: Pyro, Pyroptosis
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1138  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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