Igs Cancer Research Results

Igs, immunoglobulins (IgG and IgM): Click to Expand ⟱
Source:
Type:
Immunoglobulins, particularly IgG and IgM, are traditionally recognized as components of the adaptive immune response; however, they have also been observed to be expressed by certain tumor cells or to play roles in the tumor microenvironment.

Immunoglobulins (Igs) are antibodies that mediate humoral immunity. IgM typically represents the initial antibody response to antigens, while IgG is involved in long-term immunity and immunological memory.

IgG and IgM are critical players in the immune response, and their presence in tumors can reflect either an active anti-tumor immune response or, in some cases, aberrant expression by tumor cells that may contribute to malignancy.
A high density of immune cells producing these antibodies generally correlates with improved prognosis, reflecting an effective immune reaction against the tumor.
Scientific Papers found: Click to Expand⟱
1641- HCAs,    Lung cancer induced by Benzo(A)Pyrene: ChemoProtective effect of sinapic acid in swiss albino mice
- in-vitro, Lung, A549 - in-vivo, Lung, NA
AntiCan↑, administration of sinapic acid ameliorates the exposure of B[a]P mediated lung cancer in swiss albino mice
Igs↓, administration of sinapic acid ameliorates the exposure of B[a]P mediated lung cancer in swiss albino mice by a decline in IgG and IgM level
lipid-P↓,
ROS↑, elevation of ROS production and caspase activity (caspase-3 and caspase-9)
Casp3↑,
Casp9↑,
ChemoSideEff↓, effective chemo preventative agent against lung carcinogenesis.
Dose∅, The IC50 value of sinapic acid was 50 µM. Hence, 50 and 75 µM dosage was selected for the additional assessments of anti-cancer efficacy of sinapic acid in the A459 cells


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

lipid-P↓, 1,   ROS↑, 1,  

Cell Death ⓘ

Casp3↑, 1,   Casp9↑, 1,  

Immune & Inflammatory Signaling ⓘ

Igs↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose∅, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   ChemoSideEff↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Igs, immunoglobulins (IgG and IgM)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1156  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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