HbA1c Cancer Research Results

HbA1c, hemoglobin A1c: Click to Expand ⟱
Source:
Type:
HbA1c is a glycated form of hemoglobin that reflects the average blood glucose concentration over the previous two to three months.
– It is commonly used in the clinical management of diabetes to monitor long-term blood sugar control.
– Since hyperglycemia has been linked to oxidative stress and low-grade inflammation, HbA1c serves as an indirect indicator of metabolic dysfunction.

– Cancer cells often reprogram metabolic pathways to support growth; systemic metabolic status (reflected by HbA1c) can influence tumor behavior.
– Chronic hyperglycemia (and thus elevated HbA1c) may lead to a pro-inflammatory state and increased production of reactive oxygen species (ROS), potentially affecting tumor progression.

– Several clinical studies have found that cancer patients with high HbA1c levels tend to have poorer overall survival compared to those with controlled glycemic levels.
– Elevated HbA1c may be associated with more aggressive tumor characteristics, treatment resistance, and higher incidence of treatment-related complications.
– In cancers such as colorectal, breast, and pancreatic, metabolic disturbances indicated by increased HbA1c have been linked to unfavorable prognostic outcomes.
Scientific Papers found: Click to Expand⟱
1681- PBG,    Propolis: Its Role and Efficacy in Human Health and Diseases
- Review, Nor, NA
*Inflam↓,
*AntiCan↑,
*antiOx↑,
*hyperG↓, flavanone glycoside found in propolis, has been reported to have insulin-like and lipid-reducing properties that reduce both insulin resistance and hyperglycemia
*BG↓, These flavonoids, including apigenin, naringin, chrysin, galangin, kaempferol, luteolin, genistein, and quercetin help to reduce blood glucose concentration
*HbA1c↓, propolis showed significant effects, reducing the blood glucose levels, serum insulin, and serum glycosylated haemoglobin (HbA1c) levels of T2DM patients
*NF-kB↓, propolis can also suppress inflammatory cascades by blocking the NF-κB pathway and reducing ROS by enhancing antioxidants
*ROS↓,
*TGF-β↑, formation of the transforming growth factor-β1 (TGF-β1) of the cells are promoted by the caffeic acid, CAPE, hesperidin, and quercetin of propolis
*selectivity↑, CAPE is a very significant compound of propolis that has anti-inflammatory properties and also acts as the selective inhibitor of NF-κB activation


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   hyperG↓, 1,   ROS↓, 1,  

Migration ⓘ

TGF-β↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

selectivity↑, 1,  

Clinical Biomarkers ⓘ

BG↓, 1,   HbA1c↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,  
Total Targets: 10

Scientific Paper Hit Count for: HbA1c, hemoglobin A1c
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1168  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

Home Page