CA125 Cancer Research Results

CA125, CA125: Click to Expand ⟱
Source:
Type:
CA125 is a protein that is often measured in the blood as a tumor marker, primarily in the context of ovarian cancer.

-CA125 is most commonly used to monitor treatment response in patients already diagnosed with ovarian cancer and to detect its recurrence.
-It may be elevated in many cases of ovarian cancer, especially the epithelial type, making it a useful marker in certain clinical settings.
Scientific Papers found: Click to Expand⟱
2169- dietF,    Prolonged stabilization of platinum-resistant ovarian cancer in a single patient consuming a fermented soy therapy
- Case Report, Ovarian, NA
OS↑, Upon initiating self-directed treatment with Haelan951, a commercially available fermented soy beverage, she entered into a phase of prolonged disease stabilization including improvement in the serum tumor marker CA-125.
CA125↓,
eff↑, Fermented soy products are known to contain high concentrations of the isoflavone, genistein, and other compounds that exhibit anticancer activity in preclinical models.

2503- H2,    Brain Metastases Completely Disappear in Non-Small Cell Lung Cancer Using Hydrogen Gas Inhalation: A Case Report
- Case Report, Lung, NA
TumVol↓, Hydrogen-gas monotherapy was started to control the tumor a month later. After 4 months, the size of multiple brain tumors was reduced significantly
OS↑, After 1 year, all brain tumors had disappeared, and there were no significant changes in metastases in the liver and lung.
Dose↝, The hydrogen oxygen nebulizer (AMS-H-03, Asclepius Meditec, Shanghai, China) generates 3 L/min hydrogen gas by hydrocephalus electrolysis. As measured by gas chromatography, the gas generated consisted of 67% hydrogen and 33% oxygen.
Dose↝, Using a special mask, the patient continued to inhale hydrogen for 3–6 hrs a day at rest, with no interruption even after the obvious relief of symptoms.
CEA↓, dropped from 29.44 to 12 ng/mL in 12 months (figure 3)
CA125↓, dropped from 150 to 60 u/mL (figure 3)
CYFRA21-1↓, dropped from 12 to 6 ng/mL (figure 3)
SIRT1↓, several scholars have demonstrated that hydrogen can suppress SIRT1 signaling in different model
COX2↓, hydrogen exerts neuroprotective effects by reducing cyclooxygenase-2 activity25 or activating expression of anti-apoptotic protein kinase B.
IL1β↓, Hydrogen inhalation can down-regulate the expression of various pro-inflammatory cytokines, including interleukin (IL)-1β, IL-6, tumor necrosis factor-α, intracellular adhesion molecule-1, high mobility group box-1, nuclear factor-kappa B, and prosta
IL6↓,
TNF-α↓,
HMGB1↓,
NF-kB↓,
EP2↓, and prostaglandin-E2

1714- Lyco,    Lycopene reduces ovarian tumor growth and intraperitoneal metastatic load
- in-vitro, Ovarian, OV-MZ-6 - in-vivo, NA, NA
ChemoSen↑, Lycopene treatment synergistically enhanced anti-tumorigenic effects of paclitaxel and carboplatin
CA125↓, Lycopene decreased the expression of the ovarian cancer biomarker, CA125.
ITGA5↓, down-regulated expression of ITGA5, ITGB1, MMP9, FAK, ILK and EMT markers, decreased protein expression of integrin α5 and reduced activation of MAPK.
ITGB1↓,
MMP9↓,
FAK↓,
EMT↓,
MAPK↓,
MMP9↓, Levels of MMP9 in serum and ascites were reduced upon lycopene prevention
antiOx↑, The antioxidant properties of lycopene have been reported for the prevention and treatment of different tumor entities, especially in prostate cancer
Ki-67↓, expression of Ki67 in tumor tissues was lowered upon lycopene treatment compared to the placebo
MAPK↓, reduced the protein expression of integrin α5 and activation of MAPK signaling


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,  

Core Metabolism/Glycolysis ⓘ

SIRT1↓, 1,  

Cell Death ⓘ

MAPK↓, 2,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   EP2↓, 1,  

Migration ⓘ

CEA↓, 1,   FAK↓, 1,   ITGA5↓, 1,   ITGB1↓, 1,   Ki-67↓, 1,   MMP9↓, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   HMGB1↓, 1,   IL1β↓, 1,   IL6↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   Dose↝, 2,   eff↑, 1,  

Clinical Biomarkers ⓘ

CA125↓, 3,   CEA↓, 1,   CYFRA21-1↓, 1,   IL6↓, 1,   Ki-67↓, 1,  

Functional Outcomes ⓘ

OS↑, 2,   TumVol↓, 1,  
Total Targets: 27

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CA125, CA125
1 diet Fermented Foods
1 Hydrogen Gas
1 Lycopene
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1176  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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