LC3B-II Cancer Research Results

LC3B-II, LC3B-II: Click to Expand ⟱
Source:
Type:
LC3B-II is a lipidated form of LC3B that is widely used as a marker for autophagy.

-Several studies have reported that higher levels of LC3B-II correlate with more aggressive tumor behavior.
-Prognostic Implication: Increased LC3B-II expression is often associated with poorer prognosis, including reduced overall survival and disease‐free survival. This may reflect a role for autophagy in tumor cell survival under stress.

-Dual Role of Autophagy: Autophagy (and therefore LC3B-II expression) may act as both a tumor suppressor and a tumor promoter depending on the tumor type, stage, and microenvironment.
Scientific Papers found: Click to Expand⟱
7041- GA,    Gallic acid suppresses the progression of clear cell renal cell carcinoma through inducing autophagy via the PI3K/Akt/Atg16L1 signaling pathway
- vitro+vivo, RCC, 786-O - in-vitro, RCC, ACHN - in-vitro, Nor, HK-2
selectivity↑, GA had a more potent viability inhibitory effect on ccRCC cells (786-O and ACHN) than the effect on normal renal tubular epithelial cell (HK-2), which demonstrated that GA selectively inhibits the viability of cancer cells.
TumCP↓, GA dose-dependently inhibited the proliferation, migration and invasion of ccRCC cells in vitro and in vivo.
TumCMig↓,
TumCI↓,
TumCCA↑, GA blocks the cycle process of ccRCC cells
TumVol↓, Moreover, the weight and volume of tumors were significantly lighter and smaller in the GA-treated group than in the control group
TumW↓,
Ki-67↓, significant decrease in the expression of Ki-67 (a marker of proliferation) and MMP-9 (a marker of metastasis) in the GA-treated group compared with the control group
MMP9↓,
TumAuto↑, GA induces autophagy in ccRCC
LC3B-II↓, LC3B-II and Beclin-1 protein expression was significantly decreased and P62 protein expression was significantly increased in the GA (IC50) + 3-MA treatment group compared with the GA (IC50) group
Beclin-1↓,
p62↑,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↓, 1,   LC3B-II↓, 1,   p62↑, 1,   TumAuto↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Migration(tgid=13) ⓘ

Ki-67↓, 1,   MMP9↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

Ki-67↓, 1,  

Functional Outcomes(tgid=23) ⓘ

TumVol↓, 1,   TumW↓, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: LC3B-II, LC3B-II
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1208  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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