Thiols Cancer Research Results

Thiols, Thiols: Click to Expand ⟱
Source:
Type:
"Thiols" generally refer to compounds containing sulfhydryl (–SH) groups, with glutathione (GSH) being one of the most abundant and well-studied cellular thiols. Thiol groups play essential roles in maintaining redox balance, detoxifying reactive oxygen species (ROS), and modulating protein function via post-translational modifications.

• Elevated levels of glutathione and related thiols have been associated with enhanced resistance to chemotherapy and radiation, as these treatments often work by inducing oxidative damage.
Scientific Papers found: Click to Expand⟱
5273- 3BP,    The promising anticancer drug 3-bromopyruvate is metabolized through glutathione conjugation which affects chemoresistance and clinical practice: An evidence-based view
- Review, Var, NA
AntiCan↑, ROS↑, angioG↓, CSCs↓, Warburg↓, GSH↓, Thiols↓,
2667- AL,    Allicin in Digestive System Cancer: From Biological Effects to Clinical Treatment
- Review, GC, NA
AntiCan↑, ChemoSen↑, angioG↓, chemoP↑, *GutMicro↑, *antiOx↑, other↝, GSH↓, Thiols↓, *ROS↓, *hepatoP↑, *Inflam↓, *NF-kB↓,
5167- AL,    The Effects of Allicin, a Reactive Sulfur Species from Garlic, on a Selection of Mammalian Cell Lines
- in-vitro, Nor, 3T3 - in-vitro, BC, MCF7 - in-vitro, Lung, A549 - in-vitro, CRC, HT-29
Thiols↓, tumCV↓, TumCP↓, GSH↓, GSSG↑, ROS↑,
5166- AL,    Antimicrobial properties of allicin from garlic
- in-vitro, Nor, NA
*Bacteria?, *Thiols↓, *TrxR↓,
5165- AL,    The human allicin-proteome: S-thioallylation of proteins by the garlic defence substance allicin and its biological effects
- in-vitro, AML, Jurkat - in-vitro, Nor, L929
necrosis↑, Thiols↓, GSH↓, ENO1↓, Zn2+↑, Glycolysis↓, ATP↓, BioAv↓,
6388- Eug,    Eugenol’s anti-cancer properties, its modulation of signalling pathways, and cascades across various cancers: A review
- Review, Var, NA
Dose↝, AntiCan↑, *Inflam↓, *cardioP↑, *neuroP↑, angioG↓, TumMeta↓, *BioAv↑, *eff↑, *toxicity↝, antiNeop↑, TumCCA↑, Apoptosis↑, *antiOx↑, *lipid-P↓, *ROS↓, *SOD↑, *Catalase↑, *GSTs↑, *GPx↑, *iNOS↓, *COX2↓, *IL6↓, *TNF-α↓, *AntiArt↑, *Bacteria↓, TumAuto↑, PI3K↓, Akt↓, FOXO3↝, BAX↑, mTOR↓, NF-kB↓, P53↑, TumCG↓, CSCs↓, CD44↓, EpCAM↓, NOTCH1↓, OCT4↓, Bcl-2↓, PDK1↓, HER2/EBBR2↓, BAD↓, cycD1/CCND1↓, ROS↑, Casp3↑, selectivity↑, MMP2↓, MMP9↓, TIMP1↑, VEGF↓, VEGFR1↓, RECK↑, TIMP2↑, DNAdam↑, MMP↓, Thiols↓, PARP↑, *Pain↓, E2Fs↓, survivin↓,
6333- Eug,  Cisplatin,  Rad,    Eugenol Exerts Apoptotic Effect and Modulates the Sensitivity of HeLa Cells to Cisplatin and Radiation
- in-vitro, Cerv, HeLa
TumCP↓, LDH↝, ChemoSen↑, RadioS↑, Casp3↑, BAX↑, Cyt‑c↑, Casp9↑, Bcl-2↓, COX2↓, IL1β↓, ROS↑, NF-kB↓, COX2↓, TumCCA↓, Thiols↓, GSH↓,
184- MFrot,  MF,    Rotating Magnetic Fields Inhibit Mitochondrial Respiration, Promote Oxidative Stress and Produce Loss of Mitochondrial Integrity in Cancer Cells
- in-vitro, GBM, GBM
ROS↑, mitResp↓, mtDam↑, Dose↝, MMP?, OCR↓, mt-H2O2↑, eff↓, SDH↓, Thiols↓, GSH↓, TumCD↑, Casp3↑, Casp7↑, MPT↑, Cyt‑c↑, selectivity↑, GSH/GSSG↓, ETC↓,
2004- PLB,    Plumbagin Inhibits Proliferative and Inflammatory Responses of T Cells Independent of ROS Generation But by Modulating Intracellular Thiols
- in-vivo, Var, NA
TumCP↓, TumCG↓, NF-kB↓, ROS↑, GSH↓, eff↓, i-Thiols↓, GSH/GSSG↓, *GSH↓, *ROS↑,
1996- PTL,    Critical roles of intracellular thiols and calcium in parthenolide-induced apoptosis in human colorectal cancer cells
- in-vitro, CRC, COLO205
Apoptosis↑, GSH↓, ROS↑, Ca+2↑, GRP78/BiP↑, ER Stress↑, eff↓, eff↑, Thiols↓,
5085- SSE,    Intravenous Infusion of High Dose Selenite in End-Stage Cancer Patients: Analysis of Systemic Exposure to Selenite and Seleno-Metabolites
- Review, Var, NA
toxicity↝, Half-Life↝, ROS↑, Thiols↓, NADPH↓, toxicity↝, other↝,

Showing Research Papers: 1 to 11 of 11

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 11

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GSH↓, 8,   GSH/GSSG↓, 2,   GSSG↑, 1,   mt-H2O2↑, 1,   ROS↑, 8,   Thiols↓, 9,   i-Thiols↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Zn2+↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   ETC↓, 1,   mitResp↓, 1,   MMP?, 1,   MMP↓, 1,   MPT↑, 1,   mtDam↑, 1,   OCR↓, 1,   SDH↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ENO1↓, 1,   Glycolysis↓, 1,   LDH↝, 1,   NADPH↓, 1,   PDK1↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 2,   BAD↓, 1,   BAX↑, 2,   Bcl-2↓, 2,   Casp3↑, 3,   Casp7↑, 1,   Casp9↑, 1,   Cyt‑c↑, 2,   necrosis↑, 1,   survivin↓, 1,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 2,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,   GRP78/BiP↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   P53↑, 1,   PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   E2Fs↓, 1,   TumCCA↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD44↓, 1,   CSCs↓, 2,   EpCAM↓, 1,   FOXO3↝, 1,   mTOR↓, 1,   NOTCH1↓, 1,   OCT4↓, 1,   PI3K↓, 1,   TumCG↓, 2,   Zn2+↑, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   MMP2↓, 1,   MMP9↓, 1,   RECK↑, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TumCP↓, 3,   TumMeta↓, 1,   VEGFR1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 2,   IL1β↓, 1,   NF-kB↓, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   ChemoSen↑, 2,   Dose↝, 2,   eff↓, 3,   eff↑, 1,   Half-Life↝, 1,   RadioS↑, 1,   selectivity↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

HER2/EBBR2↓, 1,   LDH↝, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   antiNeop↑, 1,   chemoP↑, 1,   toxicity↝, 2,  
Total Targets: 86

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   Catalase↑, 1,   GPx↑, 1,   GSH↓, 1,   GSTs↑, 1,   lipid-P↓, 1,   ROS↓, 2,   ROS↑, 1,   SOD↑, 1,   Thiols↓, 1,   TrxR↓, 1,  

Cell Death(tgid=5) ⓘ

iNOS↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   IL6↓, 1,   Inflam↓, 2,   NF-kB↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

GutMicro↑, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   hepatoP↑, 1,   neuroP↑, 1,   Pain↓, 1,   toxicity↝, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria?, 1,   Bacteria↓, 1,  
Total Targets: 29

Scientific Paper Hit Count for: Thiols, Thiols
4 Allicin (mainly Garlic)
2 Eugenol
1 3-bromopyruvate
1 Cisplatin
1 Radiotherapy/Radiation
1 Magnetic Field Rotating
1 Magnetic Fields
1 Plumbagin
1 Parthenolide
1 Selenite (Sodium)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1224  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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