Prot Cancer Research Results

Prot, Protein Levels: Click to Expand ⟱
Source:
Type:
Protein Levels
Scientific Papers found: Click to Expand⟱
2064- PB,  Rad,    Phenylbutyrate Attenuates the Expression of Bcl-XL, DNA-PK, Caveolin-1, and VEGF in Prostate Cancer Cells
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
Bcl-xL↓, PB attenuates the expression of the apoptosis antagonist Bcl-XL, the double-strand break repair protein DNA-dependent protein kinase, the prostate progression marker caveolin -1, and the pro-angiogenic vascular endothelial growth factor
Cav1↓, PB Inhibits the Protein Expression of DNA-PK and Caveolin-1 in Prostate Cancer Cells
VEGF↓, Secretion of VEGF from Prostate Cancer Cells is Attenuated by PB
RadioS↑, PB was found to act in synergy with ionizing radiation to induce apoptosis in prostate cancer cells
chemoP↑, Moreover, butyrate may act as a chemopreventive agent against colon cancer [22]
HDAC↓, mechanism of action of butyrate and butyrate derivatives involves inhibition of the histone deacetylase activity in cells
*toxicity↓, Due to its low toxicity in vivo
Diff↑, differentiation-inducing activity towards cancer cells, PB and other butyrate derivatives have been considered as potential anticancer agents
Prot↓, Thus, our results show that PB can, like butyrate, attenuate the protein levels of Bcl-XL in prostate cancer cells.


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

Cav1↓, 1,  

Cell Death ⓘ

Bcl-xL↓, 1,  

Transcription & Epigenetics ⓘ

Prot↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

Diff↑, 1,   HDAC↓, 1,  

Angiogenesis & Vasculature ⓘ

VEGF↓, 1,  

Drug Metabolism & Resistance ⓘ

RadioS↑, 1,  

Functional Outcomes ⓘ

chemoP↑, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: Prot, Protein Levels
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1243  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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