DLEU1 Cancer Research Results
DLEU1, Deleted in Lymphocytic Leukemia 1: Click to Expand ⟱
| Source: |
| Type: oncogenic lncRNA |
DLEU1 (Deleted in Lymphocytic Leukemia 1)
-In many studies, higher levels of DLEU1 expression have been associated with increased tumor aggressiveness and poorer clinical outcomes.
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Scientific Papers found: Click to Expand⟱
ROS↑, Shikonin could induce reactive oxygen species (ROS), lipid ROS, intracellular ferrous iron (Fe2+), and malondialdehyde (MDA) in GC.
lipid-P↑,
Iron↑,
MDA↑,
GPx4↓, shikonin decreased the expression of GPX4 by suppressing GPX4 synthesis and decreasing ferritin.
Ferritin↓,
DLEU1↓, shikonin decreased DLEU1 expression in GC cells
mTOR↓, shikonin might decrease GPX4 levels by inhibiting the DLEU1/mTOR pathway.
Ferroptosis↑, shikonin-induced ferroptosis
Showing Research Papers: 1 to 1 of 1
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress ⓘ
Ferroptosis↑, 1, GPx4↓, 1, Iron↑, 1, lipid-P↑, 1, MDA↑, 1, ROS↑, 1,
Metal & Cofactor Biology ⓘ
Ferritin↓, 1,
Cell Death ⓘ
Ferroptosis↑, 1,
Transcription & Epigenetics ⓘ
DLEU1↓, 1,
Proliferation, Differentiation & Cell State ⓘ
mTOR↓, 1,
Clinical Biomarkers ⓘ
Ferritin↓, 1,
Total Targets: 11
Pathway results for Effect on Normal Cells:
Total Targets: 0
Scientific Paper Hit Count for: DLEU1, Deleted in Lymphocytic Leukemia 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:1261 State#:% Dir#:1
wNotes=on sortOrder:rid,rpid
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