ATF3 Cancer Research Results

ATF3, Activating Transcription Factor 3: Click to Expand ⟱
Source:
Type:
ATF3 (Activating Transcription Factor 3) is a stress‐responsive transcription factor that is frequently induced by various cellular stresses, including DNA damage, oxidative stress, and inflammatory signals.

-Several studies have shown that ATF3 is upregulated in response to cellular stress in breast cancers.
-Increased ATF3 expression has been associated with reduced cell proliferation and invasiveness, suggesting a tumor-suppressive role.

• In some cancers and contexts, elevated ATF3 is linked with apoptosis induction and a favorable prognosis, acting as a tumor suppressor.
Scientific Papers found: Click to Expand⟱
2735- BetA,    Betulinic acid as apoptosis activator: Molecular mechanisms, mathematical modeling and chemical modifications
- Review, Var, NA
mt-Apoptosis↑, Casp↑, p38↑, MAPK↓, JNK↓, VEGF↓, AIF↑, Cyt‑c↑, ROS↑, Ca+2↑, ATP↓, NF-kB↓, ATF3↓, TOP1↓, VEGF↓, survivin↓, Sp1/3/4↓, MMP↓, ChemoSen↑, selectivity↑, BioAv↓, BioAv↑, BioAv↑, BioAv↑, BioAv↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ATF3↓, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 1,   MMP↓, 1,  

Cell Death ⓘ

mt-Apoptosis↑, 1,   Casp↑, 1,   Cyt‑c↑, 1,   JNK↓, 1,   MAPK↓, 1,   p38↑, 1,   survivin↓, 1,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

TOP1↓, 1,  

Migration ⓘ

Ca+2↑, 1,  

Angiogenesis & Vasculature ⓘ

VEGF↓, 2,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 4,   ChemoSen↑, 1,   selectivity↑, 1,  
Total Targets: 21

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ATF3, Activating Transcription Factor 3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1263  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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