CYP2C6 Cancer Research Results

CYP2C6, CYP2C6: Click to Expand ⟱

Source:

Type:

CYP2C6 belongs to the cytochrome P450 family of enzymes, which are primarily involved in the metabolism of both endogenous and exogenous compounds—including drugs and potential carcinogens.

-More than 95% of drugs and natural products are metabolized by CYPs, of which CYP1A, CYP2C, CYP2D, and CYP3A are the most important.

Scientific Papers found: Click to Expand⟱

7751-

ISL,

LE,

Cytochrome P450 inhibition by three licorice species and fourteen licorice constituents

*CYP2C6↓, The licorice compounds isoliquiritigenin, licoricidin, licochalcone A, 18β-glycyrrhetinic acid, and glycycoumarin inhibited one or more members of the CYP2C family of enzymes.
*CYP3A4↓, Isoliquiritigenin, glabridin and licoricidin competitively inhibited CYP3A4
*P450↓, varying potential for drug-botanical interactions as inhibitors of cytochrome P450 isoforms.
*other↑, Each species of licorice displays a unique profile of constituents with potential for drug interactions.

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Core Metabolism/Glycolysis(tgid=4) ⓘ

CYP2C6↓, 1, CYP3A4↓, 1,

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

P450↓, 1,
Total Targets: 4

Scientific Paper Hit Count for: CYP2C6, CYP2C6

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells