CYP3A2 Cancer Research Results
CYP3A2, CYP3A2: Click to Expand ⟱
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CYP3A2 is part of the CYP3A enzyme subfamily, which is well known for its role in metabolizing a broad range of substrates, including drugs and potentially carcinogenic compounds.
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Scientific Papers found: Click to Expand⟱
*Inflam↓, pharmacological effects of baicalin and baicalein, such as anti-inflammation, anti-cancer, and anti-pruritic effects, have been reported in the literature [
AntiCan↑,
BioAv↝, Baicalin is metabolized to baicalein by β-glucuronidase in the intestine [12], and this metabolic process is a critical stage for absorption of baicalin [6,12].
BioAv⇅, literature indicated that the kinds and numbers of intestinal microbiota in individuals might affect the pre-systemic metabolism and absorption process of baicalin in the intestine
BioAv↓, significantly reduced bioavailability of baicalin was obtained in antibiotic-pretreated rats when compared with normal rats.
CYP3A2↓, CYP3A inhibition P-gp inhibition
P-gp↓,
*ROS↓, Numerous studies suggested that B monnieri’s bioactive components (ie, bacosides) protect the brain against oxidative damage and age-related cognitive deterioration with several mechanisms of action
*cognitive↑, patients who took 300 mg of Bacognize orally twice a day showed a statistically significant improvement in various components of Mini-Mental State Examination Scale (MMSES)
*memory↑, (BME)-treated rat serum and could directly or indirectly interact with the neurotransmitter systems to improve memory and learning ability
*BBB↑, Bacosides present in B monnieri are commonly nonpolar glycosides,27 which enable it to cross the blood-brain barrier (BBB) via simple lipid-mediated passive diffusion.
*P-gp↓, The results showed that B. monnieri downregulated both intestinal Pgp and CYP3A expression levels, depending on the testosterone hydroxylase catalytic activity in liver and intestine
*CYP3A2↓,
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*antiOx↑, Black pepper (Piper Nigrum L.) is an important healthy food owing to its antioxidant, antimicrobial potential and gastro-protective modules
*ROS↓, The free-radical scavenging activity of black pepper and its active ingredients might be helpful in chemoprevention and controlling progression of tumor growth.
*chemoP↑,
TumCG↓,
*cognitive↑, piperine assist in cognitive brain functioning, boost nutrient's absorption and improve gastrointestinal functionality
*MMPs↓, They postulated that inhibition of interlukon, matrix metalloproteinase, prostaglandin E2, and activator protein 1 are possible routes for their said properties
*PGE2↓,
*AP-1↓,
*5LO↓, Piperine along with some other components can inhibit the expression of enzymes like 5-lipoxygenase and COX-1 that
are responsible for leukotriene and prostaglandin biosynthesis.
*COX1↓,
*other↑, It is widely accepted that black pepper is instrumental to prevent and cure gastrointestinal problems. The black pepper enhances the production of hydrochloric acid from stomach thus improving digestion through stimulation of histamine H2 recepto
*other↑, black pepper has diaphoretic (promotes sweating), and diuretic (promotes urination) properties
*other↑, Moreover, it protects intestinal membranes from gastric secretions and ROS damage owing to antioxidant potential.
*SOD↑, black pepper significantly enhanced the activities of antioxidant enzymes, that is, SOD, CAT, GR, and GST.
*Catalase↑,
*GSTs↑,
*GSR↑,
*other↑, black pepper and its active ingredients improve expression of
some digestive enzymes along with increase in the secretion of
saliva
*Weight↓, piperine intake may decrease body weight
*BioEnh↑, The black pepper and piperine improve the bioavailability of many drugs.
*BioAv↑, Piperine also boosts the bioavailability of important phyto-
chemicals contained in other foods, for example, bioactive com-
ponents present in curcumin and green tea
*eff↑, The combination of piperine (2.5 mg/kg, i.p., 21 days) with curcumin (20 and 40 mg/kg, i.p., 21 days) showed improved anti-immobility, neurotransmitter enhancing, and monoamine oxidase inhibitory (MAO-A) effects of curcumin
*CYP3A2↓, combination of curcumin and piperine is most likely to inhibit CYP3A, CYP2C9, UGT, and SULT metabolism within the intestinal mucosa (Volak et al., 2008)
*neuroP↑, Neuroprotective Potential of Black Pepper
*BP↓, Piperine (20 mg/kg/day) decreased
the blood pressure caused by the blockage of voltage-dependent
calcium channels
*other↑, black pepper oil is one of the strongest appetizer; inhalation stimulates the swallowing
in post stroke patients with dysphagia.
Showing Research Papers: 1 to 3 of 3
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3
Pathway results for Effect on Cancer / Diseased Cells:
Core Metabolism/Glycolysis ⓘ
CYP3A2↓, 1,
Proliferation, Differentiation & Cell State ⓘ
TumCG↓, 1,
Barriers & Transport ⓘ
P-gp↓, 1,
Drug Metabolism & Resistance ⓘ
BioAv↓, 1, BioAv⇅, 1, BioAv↝, 1,
Functional Outcomes ⓘ
AntiCan↑, 1,
Total Targets: 7
Pathway results for Effect on Normal Cells:
Redox & Oxidative Stress ⓘ
antiOx↑, 1, Catalase↑, 1, GSR↑, 1, GSTs↑, 1, ROS↓, 2, SOD↑, 1,
Core Metabolism/Glycolysis ⓘ
CYP3A2↓, 2,
Transcription & Epigenetics ⓘ
other↑, 5,
Migration ⓘ
5LO↓, 1, AP-1↓, 1, MMPs↓, 1,
Barriers & Transport ⓘ
BBB↑, 1, P-gp↓, 1,
Immune & Inflammatory Signaling ⓘ
COX1↓, 1, Inflam↓, 1, PGE2↓, 1,
Drug Metabolism & Resistance ⓘ
BioAv↑, 1, BioEnh↑, 1, eff↑, 1,
Clinical Biomarkers ⓘ
BP↓, 1,
Functional Outcomes ⓘ
chemoP↑, 1, cognitive↑, 2, memory↑, 1, neuroP↑, 1, Weight↓, 1,
Total Targets: 25
Scientific Paper Hit Count for: CYP3A2, CYP3A2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:1269 State#:% Dir#:1
wNotes=on sortOrder:rid,rpid
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