PONs Cancer Research Results

PONs, paraoxonase: Click to Expand ⟱
Source:
Type:
Paraoxonases refer to a family of enzymes—primarily PON1, PON2, and PON3—that are involved in the detoxification of oxidized lipids and the metabolism of various xenobiotics. Their roles in modulating oxidative stress and inflammation have attracted attention in cancer research.

-Upregulation in Some Tumors: In certain cancer types, elevated expression of paraoxonase enzymes may occur as an adaptive response to increased oxidative stress. For instance, some tumors demonstrate increased levels of PON2, which could help protect cancer cells from oxidative damage.
Scientific Papers found: Click to Expand⟱
2255- MF,    Pulsed Electromagnetic Fields Induce Skeletal Muscle Cell Repair by Sustaining the Expression of Proteins Involved in the Response to Cellular Damage and Oxidative Stress
- in-vitro, Nor, SkMC
*HSP70/HSPA5↑, HSP70), which can promote muscle recovery, inhibits apoptosis and decreases inflammation in skeletal muscle, together with thioredoxin, paraoxonase, and superoxide dismutase (SOD2), which can also promote skeletal muscle regeneration following injury
*Apoptosis↓,
*Inflam↓,
*Trx↓,
*PONs↓, Paraoxonase 2 (PON2, Paraoxonase 3 (PON3) (+19% vs. controls)
*SOD2↓,
*TumCG↑, PEMF treatment enhanced muscle cell proliferation by approximately 20% both in cells grown in complete medium
*Diff↑, suggest the potential role of PEMF in the induction of muscle differentiation
*HIF2a↑, hypoxia-inducible transcription factor 2a (HIF-2a) (+40% vs. controls),
*Cyt‑c↑, Cytochrome c (+39% vs. controls)
P21↑, p21/CIP1 (+27% vs. controls)


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Cycle & Senescence ⓘ

P21↑, 1,  
Total Targets: 1

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

SOD2↓, 1,   Trx↓, 1,  

Core Metabolism/Glycolysis ⓘ

PONs↓, 1,  

Cell Death ⓘ

Apoptosis↓, 1,   Cyt‑c↑, 1,  

Protein Folding & ER Stress ⓘ

HSP70/HSPA5↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

Diff↑, 1,   TumCG↑, 1,  

Angiogenesis & Vasculature ⓘ

HIF2a↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  
Total Targets: 10

Scientific Paper Hit Count for: PONs, paraoxonase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1273  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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