MIP‑1α/CCL3 Cancer Research Results

MIP‑1α/CCL3, C-C Motif Chemokine Ligand 3: Click to Expand ⟱
Source:
Type:
CCL3 (Macrophage Inflammatory Protein-1α, MIP‑1α)

-CCL3 acts as a chemoattractant for various immune cells including NK cells, dendritic cells, and monocytes.

– Its role in tumors can be dual: promoting anti-tumor responses in some contexts while in others, especially through chronic inflammation, it may participate in tumor progression.

CCL3 - C-C Motif Chemokine Ligand 3

Abbreviation: CCL3, MIP-1α

Type: Chemokine / inflammatory cytokine

Function: CCL3 is a CC-family chemokine that signals primarily through CCR1 and CCR5 and regulates recruitment and activation of monocytes, macrophages, lymphocytes, and other immune cells. It plays important roles in inflammatory responses, immune-cell trafficking, and tumor-microenvironment signaling.

Cancer: ↕ Context-dependent. CCL3 can support antitumor immune-cell recruitment in some settings, but elevated CCL3 frequently promotes a pro-inflammatory tumor microenvironment, recruitment of tumor-supportive myeloid cells, angiogenesis, invasion, metastasis, and treatment resistance.

Alzheimer's Disease: ↑ Increased CCL3 is associated with neuroinflammation and activation or recruitment of microglia and other immune cells in Alzheimer's disease and related neurodegenerative models.
Scientific Papers found: Click to Expand⟱
3515- Bor,    EVIDENCE THAT BORON DOWN-REGULATES INFLAMMATION THROUGH THE NF-(KAPPA)B PATHWAY
- in-vitro, Nor, NA
*TNF-α↓, *IL1β↓, *MIP‑1α/CCL3↓, *iNOS↓, *NF-kB↓,
7325- GSE,    The Effects of a Grape Seed Procyanidin Extract on Cytochrome P450 3A4 Activity and Inflammatory Mediators in the Lungs of Heavy Active and Former Smokers
- in-vitro, Lung, NA
*cardioP↑, *Inflam↓, BioAv↑, TNF-α↓, MIP‑1α/CCL3↓, GranB/GZMB↓,
7784- ISL,    Isoliquiritigenin attenuates lipopolysaccharide-induced cognitive impairment through antioxidant and anti-inflammatory activity
- in-vivo, AD, NA
*Learn↑, *PSD95↑, *BDNF↑, *SOD↑, *GPx↑, *Bcl-2↑, *SYP↑, *Bax:Bcl2↓, *TNF-α↓, *IL1β↓, *IL6↓, *MIP‑1α/CCL3↓, *p‑GSK‐3β↑, *NRF2↑, *HO-1↑, *NQO1↑, *cognitive↑, *Inflam↓,
228- MFrot,  MF,    Rotating magnetic field ameliorates experimental autoimmune encephalomyelitis by promoting T cell peripheral accumulation and regulating the balance of Treg and Th1/Th17
- NA, MS, NA
*CD4+↑, *MCP1/CCL2↓, RANTES↓, *MIP‑1α/CCL3↓, *Treg lymp↓, *IFN-γ↓, *IL17↓, *CXCc↓,
4861- Uro,    Urolithin A improves Alzheimer's disease cognition and restores mitophagy and lysosomal functions
- in-vivo, AD, NA
*memory↑, *Aβ↓, *toxicity↓, *BBB↑, *p‑tau↓, *eff↓, *IL1α↓, *MCP1/CCL2↓, *MIP‑1α/CCL3↓, *TNF-α↓, *IL2↓, *SIRT1↓, *DNAdam↓, *Dose↝, *Strength↑, *motorD↑, *CTSZ↓,

Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death(tgid=5) ⓘ

GranB/GZMB↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

MIP‑1α/CCL3↓, 1,   RANTES↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Learn↑, 1,   SYP↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

GPx↑, 1,   HO-1↑, 1,   NQO1↑, 1,   NRF2↑, 1,   SOD↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

SIRT1↓, 1,  

Cell Death(tgid=5) ⓘ

Bax:Bcl2↓, 1,   Bcl-2↑, 1,   iNOS↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑GSK‐3β↑, 1,  

Migration(tgid=13) ⓘ

Treg lymp↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   CTSZ↓, 1,   CXCc↓, 1,   IFN-γ↓, 1,   IL17↓, 1,   IL1α↓, 1,   IL1β↓, 2,   IL2↓, 1,   IL6↓, 1,   Inflam↓, 2,   MCP1/CCL2↓, 2,   MIP‑1α/CCL3↓, 4,   NF-kB↓, 1,   TNF-α↓, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 1,   PSD95↑, 1,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   eff↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   cognitive↑, 1,   memory↑, 1,   motorD↑, 1,   Strength↑, 1,   toxicity↓, 1,  
Total Targets: 42

Scientific Paper Hit Count for: MIP‑1α/CCL3, C-C Motif Chemokine Ligand 3
1 Boron
1 Grapeseed extract
1 Isoliquiritigenin
1 Magnetic Field Rotating
1 Magnetic Fields
1 Urolithin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1275  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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