FGF21 Cancer Research Results

FGF21, FGF21: Click to Expand ⟱
Source:
Type:
Fibroblast Growth Factor 21 (FGF21). FGF21 is best known as a metabolic regulator involved in energy homeostasis.

– FGF21 is an endocrine member of the fibroblast growth factor family primarily secreted by the liver, but also produced by adipose tissue and skeletal muscle.
Scientific Papers found: Click to Expand⟱
7171- CHA,    Chaetocin-mediated SUV39H1 inhibition targets stemness and oncogenic networks of diffuse midline gliomas and synergizes with ONC201
- vitro+vivo, GBM, DIPG
TumCG↓, High-throughput small-molecule screening identified an epigenetic compound chaetocin as a potent blocker of DIPG cell growth
TumCP↓, Chaetocin treatment selectively decreased proliferation and increased apoptosis of DIPG cells and significantly extended survival in DIPG xenograft models, while restoring H3K27me3 levels
Apoptosis↓,
OS↑,
H3K9↓, he loss of H3K9 methyltransferase SUV39H1 inhibited DIPG cell growth.
SUV39H↓, SUV39H1 and H3K9me3 Levels Are Downregulated by Chaetocin Treatment
eff↑, Consistently, a combination of chaetocin treatment with a DRD2 antagonist ONC201 synergistically increased the antitumor efficacy.
CSCs↓, SUV39H1 Inhibition Decreases Stemness and Oncogenic Signaling
SOX9↓, chaetocin treatment and SUV39H1 depletion led to decreased expression of genes associated with stemness (eg, SOX9, MYCN, OLIG2, AURKB), growth factor signaling (eg, HGF, FGF21), receptor-tyrosine kinases signaling (eg, EGFR, FGFR, and PDGFR), and WNT
HGF/c-Met↓,
FGF21↓,
EGFR↓,
PDGFR-BB↓,
Wnt↓,
MYCN↑,
OLIG2↓,
AURKB↓,
HO-1↑, genes associated with the NRF2 stress pathway, oxidative stress-related genes (eg, HMOX1, ARK1C1), cell cycle inhibition (eg, CDKN1A, CDKN2B, CDKN2D), and neuronal signaling activity (eg, DRD2, NRG1, NRXN1) were upregulated
P21↑,

7150- RES,    Modulation of the PI3K/Akt signaling pathway by resveratrol in cancer: molecular mechanisms and therapeutic opportunity
- Review, Var, NA
AntiTum↑, anti-tumor capabilities of resveratrol and then emphasizes the significant role of the PI3K/Akt signaling pathway in the progression of multiple malignancies
PI3K↓,
Akt↓,
*AntiAge↑, Multiple studies in various organisms have consistently indicated that resveratrol can extend a healthy lifespan through sirtuin 1 (SIRT1) pathway activation
*SIRT1↑,
*lipid-P↓, it safeguards cell membranes from lipid peroxidation and protects DNA from damage caused by reactive oxygen species (ROS)
*ROS↓,
*BioAv↓, low bioavailability is another major challenge in clinical translation of resveratrol.
*NRF2↑, Resveratrol exerts potent antioxidant effects by activating the Nuclear factor erythroid 2-related factor 2 (Nrf2)/Heme oxygenase-1 (HO-1) signaling pathway.
*HO-1↑,
SOD↑, In various cancer types, including prostate, liver, and breast cancer, even low concentrations of resveratrol treatment significantly enhance superoxide dismutase (SOD)
HDAC1↓, Resveratrol also inhibits the MTA1/HDAC1 complex, leading PTEN reactivation and subsequently suppressing the Akt pathway.
PTEN↑,
P53↑, Resveratrol activates p53
TumCCA↑, A study found that resveratrol arrested the cell cycle at G0/G1, suppressed cell proliferation, and stimulated apoptosis in a concentration- and time-dependent manner
TumCI↓, resveratrol effectively inhibits tumor invasion and metastasis by inhibiting signaling pathways associated with EMT
TumMeta↓,
EMT↓,
MMPs↓, Resveratrol has been proposed to have a potential role in suppressing the expression of matrix metalloproteinases (MMPs), particularly MMP-9,
MMP9↓,
angioG↓, and angiogenesis-related markers such as vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR), or fibroblast growth factor (FGF)-2
VEGF↓,
EGFR↓,
FGF21↓,
HIF-1↓, resveratrol significantly hinders the proliferation of human ovarian cancer and angiogenesis by diminishing the generation of HIF-1 and VEGF.
*neuroP↑, resveratrol can use as a therapeutic option in cardiovascular health, metabolic diseases, neuroprotection, and malignancies
*cardioP↑, it acts as a cardiovascular protector in the heart
BMPs↑, Resveratrol exerts its anti-cancer effects by suppressing the PI3K/Akt pathway through the upregulation of BMP7
ROS↑, Lung Cancer: These effects were attributed to alterations in mitochondrial metabolism and the generation of excessive reactive oxygen species (ROS)
Vim↓, The researchers discovered that resveratrol lowered the amounts of vimentin, N-cadherin, MMP-3, and MMP-13 proteins while raising the levels of E-cadherin protein in HeLa and SiHa cells
N-cadherin↓,
MMP3↓,
MMP13↓,
E-cadherin↑,
Ki-67↓, A phase I trial on CRC demonstrated that resveratrol reduced cell proliferation markers, such as Ki-67, while increasing apoptotic activity in tumor tissues


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

AURKB↓, 1,   H3K9↓, 1,   MYCN↑, 1,   OLIG2↓, 1,   SUV39H↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

HO-1↑, 1,   ROS↑, 1,   SOD↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

FGF21↓, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↓, 1,   HGF/c-Met↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

SOX9↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   EMT↓, 1,   HDAC1↓, 1,   PI3K↓, 1,   PTEN↑, 1,   TumCG↓, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

E-cadherin↑, 1,   Ki-67↓, 1,   MMP13↓, 1,   MMP3↓, 1,   MMP9↓, 1,   MMPs↓, 1,   N-cadherin↓, 1,   TumCI↓, 1,   TumCP↓, 1,   TumMeta↓, 1,   Vim↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   EGFR↓, 2,   HIF-1↓, 1,   PDGFR-BB↓, 1,   VEGF↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BMPs↑, 1,   EGFR↓, 2,   Ki-67↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,   OS↑, 1,  
Total Targets: 45

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

HO-1↑, 1,   lipid-P↓, 1,   NRF2↑, 1,   ROS↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

SIRT1↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   cardioP↑, 1,   neuroP↑, 1,  
Total Targets: 9

Scientific Paper Hit Count for: FGF21, FGF21
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1279  State#:%  Dir#:1
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