PDK3 Cancer Research Results

PDK3, Pyruvate Dehydrogenase Kinase 3: Click to Expand ⟱
Source:
Type:
Pyruvate Dehydrogenase Kinase 3 (PDK3)
– PDK3 is one of the four isoenzymes of pyruvate dehydrogenase kinase (PDK1–4) that phosphorylate and inactivate the pyruvate dehydrogenase (PDH) complex.

– By inhibiting PDH, PDK3 reduces the conversion of pyruvate into acetyl-CoA, thereby diverting pyruvate from entry into the tricarboxylic acid (TCA) cycle.
– This shift promotes glycolytic metabolism (even under aerobic conditions), a hallmark of the Warburg effect observed in many cancers.

– PDK3 is typically upregulated in response to hypoxia or metabolic stress, conditions commonly encountered in the tumor microenvironment.
– Its expression can be regulated by hypoxia-inducible factor 1-alpha (HIF-1α) and other metabolic regulators, contributing to the adaptive metabolic reprogramming of cancer cells.

– Upregulated Expression: Elevated levels of PDK3 have been observed in several cancer types, including lung, colon, and breast cancers.
– Metabolic Reprogramming: Overexpression of PDK3 supports the preferential use of glycolysis over oxidative phosphorylation, allowing cancer cells to adapt to hypoxic conditions and rapid proliferation.
Scientific Papers found: Click to Expand⟱
2300- QC,    Flavonoids Targeting HIF-1: Implications on Cancer Metabolism
- Review, Var, NA
AntiTum↑, Hif1a↓, *Hif1a↑, Glycolysis↓, HK2↓, PDK3↓, PFKP?,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

Glycolysis↓, 1,   HK2↓, 1,   PDK3↓, 1,   PFKP?, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Angiogenesis & Vasculature ⓘ

Hif1a↑, 1,  
Total Targets: 1

Scientific Paper Hit Count for: PDK3, Pyruvate Dehydrogenase Kinase 3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1287  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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