VM Cancer Research Results

VM, vasculogenic mimicry: Click to Expand ⟱

Source:

Type:

Vasculogenic mimicry (VM)

-Vasculogenic mimicry refers to the process by which aggressive tumor cells form vascular channel–like structures independently of endothelial cells.
-Unlike classical angiogenesis where new blood vessels develop from preexisting vasculature, VM involves tumor cell plasticity that allows cancer cells to create perfusable networks resembling blood vessels.
-This phenomenon is often observed in highly aggressive and metastatic tumors, reflecting the ability of these cells to adapt to hypoxia and other microenvironmental stresses.

-Tumor regions with low oxygen levels often stimulate VM formation as an adaptive response. Hypoxia promotes a switch in cellular metabolism and gene expression that supports both angiogenesis and vasculogenic mimicry, thus ensuring continued nutrient supply and waste removal.

Scientific Papers found: Click to Expand⟱

2356-

SK,

ESM1 enhances fatty acid synthesis and vascular mimicry in ovarian cancer by utilizing the PKM2-dependent warburg effect within the hypoxic tumor microenvironment

in-vitro,

Ovarian,

CaOV3

in-vitro,

Ovarian,

OV90

in-vivo,

NA,

(1 mg/kg) by intraperitoneal injection once every 3 days

mice

PKM2↓, Shikonin effectively inhibits the molecular interaction between ESM1 and PKM2, consequently preventing the formation of PKM2 dimers and thereby inhibiting ovarian cancer glycolysis, fatty acid synthesis and vasculogenic mimicry.
Glycolysis↓, Shikonin inhibited glycolysis in OV90 cells
FASN↓,
lactateProd↓, In both CAOV3 and OV90 cells, the levels of lactic acid were significantly reduced in the ESM1 and Shikonin group when compared to the ESM1-overexpressing group
Warburg↓, Shikonin could repress the interaction between PKM2 and ESM1 and the formation of PKM2 dimers to attenuate OC migration and invasion and VM by driving the Warburg effect in vitro.
TumCG↓, Shikonin itself significantly inhibited tumor growth
VM↓, Shikonin significantly attenuates the OC growth and the VM of OC cells

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Core Metabolism/Glycolysis ⓘ

FASN↓, 1, Glycolysis↓, 1, lactateProd↓, 1, PKM2↓, 1, Warburg↓, 1,

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,

Angiogenesis & Vasculature ⓘ

VM↓, 1,
Total Targets: 7

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: VM, vasculogenic mimicry

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells