MDMX Cancer Research Results

MDMX, MDM4: Click to Expand ⟱
Source:
Type:
MDMX (also known as MDM4)

-MDMX, together with its homolog MDM2, is a critical negative regulator of the tumor suppressor protein p53.

-MDMX is often overexpressed in multiple cancer types through gene amplification, transcriptional upregulation, or other post-transcriptional mechanisms.
-Elevated MDMX levels can contribute to an environment of p53 inhibition, even in tumors that retain wild-type p53, thereby supporting cell proliferation and survival.
Scientific Papers found: Click to Expand⟱
2495- Fenb,    Benzimidazoles Downregulate Mdm2 and MdmX and Activate p53 in MdmX Overexpressing Tumor Cells
- in-vitro, Melanoma, A375
P53↑, Albendazole and fenbendazole, two approved and commonly used benzimidazole anthelmintics, stimulated p53 activity
P21↑, The protein levels of p53 and p21 increased upon the treatment with albendazole and fenbendazole, indicating activation of the p53–p21 pathway
TumCCA↑, G2/M cell cycle arrest of large multinucleated cells with disrupted microtubules.
MDM2↓, drugs promoted the stability and transcriptional activity of wild-type p53 via downregulation of its negative regulators Mdm2 and MdmX in cells overexpressing these proteins.
MDMX↓,
eff↑, potential for repurposing the benzimidazole anthelmintics for the treatment of cancers overexpressing p53 negative regulators.


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

MDM2↓, 1,  

DNA Damage & Repair ⓘ

MDMX↓, 1,   P53↑, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 1,   TumCCA↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: MDMX, MDM4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1313  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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