PDT+ Cancer Research Results

PDT+, PDT+cells: Click to Expand ⟱
Source:
Type:
PD-1+Tim-3+terminal CD8+ T cells (PDT+)

-In several studies across different malignancies, high frequencies of PD-1⁺Tim-3⁺ terminal CD8⁺ T cells have been associated with advanced disease stages or an immunosuppressive tumor microenvironment.
-Their accumulation may correlate with a poorer prognosis, as it reflects chronic immune stimulation and subsequent T cell dysfunction.
Scientific Papers found: Click to Expand⟱
2504- H2,    Hydrogen gas activates coenzyme Q10 to restore exhausted CD8+ T cells, especially PD-1+Tim3+terminal CD8+ T cells, leading to better nivolumab outcomes in patients with lung cancer
- Trial, Lung, NA
CD8+↑, As previously reported, hydrogen gas improves the prognosis of patients with cancer by restoring exhausted CD8+ T cells into active CD8+ T cells
OS↑, Median survival time (MST) for the HGN-treated patients was 28 months, a length that is approximately 3-fold longer than that for NO-treated patients (MST 9 months)
eff↝, (PDT+ ratio and CoQ10 ratio, respectively) revealed that patients with low PDT+ ratio (<0.81) and high CoQ10 ratio (>1.175) had significantly longer OS compared with those with high PDT+ ratio and low CoQ10 ratio
CoQ10↑, Hydrogen gas has been suggested to enhance the clinical efficacy of nivolumab by increasing CoQ10 (mitochondria) to reduce PDT+, with PDT+ and CoQ10 as reliable negative and positive biomarkers of nivolumab, respectively.
PDT+↓,
PGC-1α↑, As hydrogen gas is reported to activate PGC1-α (14), it is also one of the mitochondrial activation mediators.
Dose↝, Patients were continuously treated with nivolumab (1 mg/kg) every 2 weeks. Patients also inhaled hydrogen gas 3 h daily at their home through a cannula or mask that they rented or purchased and connected to a Hycellvator ET 100
*toxicity∅, Recently, hydrogen gas inhalation was used in patients with post-cardiac arrest syndrome, and adverse events were not observed


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

CoQ10↑, 1,  

Mitochondria & Bioenergetics ⓘ

PGC-1α↑, 1,  

Immune & Inflammatory Signaling ⓘ

PDT+↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   eff↝, 1,  

Functional Outcomes ⓘ

OS↑, 1,  

Infection & Microbiome ⓘ

CD8+↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Functional Outcomes ⓘ

toxicity∅, 1,  
Total Targets: 1

Scientific Paper Hit Count for: PDT+, PDT+cells
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1316  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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