GSDMD Cancer Research Results

GSDMD, gasdermin D: Click to Expand ⟱
Source:
Type:
GSDMD is best known for its central role in mediating pyroptosis, a form of inflammatory programmed cell death.

-Some studies suggest that increased GSDMD expression and associated pyroptosis may improve local antitumor immunity.
-Some preclinical studies indicate that enhanced pyroptosis via GSDMD activation may correlate with a better prognosis, likely through improved immune-mediated clearance of tumor cells.
Scientific Papers found: Click to Expand⟱
3471- MF,    The prevention effect of pulsed electromagnetic fields treatment on senile osteoporosis in vivo via improving the inflammatory bone microenvironment
- in-vivo, Nor, NA
*BMD↑, PEMF increased the bone mineral density of the proximal femur and L5 vertebral body and improved parameters of the proximal tibia and L4 vertebral body.
*NLRP3↓, PEMF also dramatically inhibited NLRP3-mediated low-grade inflammation in the bone marrow,
*proCasp1↓, PEMF inhibited the levels of NLRP3, proCaspase1, cleaved Caspase1, IL-1β, and GSDMD-N.
*cl‑Casp1↓,
*IL1β↓,
*GSDMD↓,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Cell Death ⓘ

cl‑Casp1↓, 1,   proCasp1↓, 1,   GSDMD↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL1β↓, 1,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Clinical Biomarkers ⓘ

BMD↑, 1,  
Total Targets: 6

Scientific Paper Hit Count for: GSDMD, gasdermin D
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1317  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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