SHP1 Cancer Research Results

SHP1, Src Homology region 2 domain-containing Phosphatase-1: Click to Expand ⟱
Source:
Type:
SHP1 is a non-receptor protein tyrosine phosphatase primarily encoded by the gene PTPN6.
Immune Checkpoint Brake, Tumor Suppressor Signaling, and Immune Evasion

– In blood cancers such as leukemia and lymphoma, altered SHP1 expression (often downregulation) is frequently observed.
– Downregulation or loss of SHP1 is often associated with more aggressive disease phenotypes and poorer prognosis.
Direction of Regulation in Cancer 
Two distinct, context-specific directions:
A. Tumor Cells (especially hematologic malignancies): DOWNREGULATED
-Frequently silenced epigenetically (promoter methylation)
-Rarely mutated; loss is regulatory
-Results in unchecked growth and survival signaling

B. Immune Cells within the Tumor Microenvironment: FUNCTIONALLY UPREGULATED
-Actively recruited by inhibitory receptors
-Suppresses T-cell, NK-cell, and myeloid anti-tumor responses
-Promotes immune evasion

This duality is critical to interpret SHP1 correctly.

When SHP1 is lost in tumor cells:
-JAK–STAT signaling becomes hyperactive
-Growth and survival pathways escape negative feedback
-Cells gain a proliferative and survival advantage


Scientific Papers found: Click to Expand⟱
2773- Bos,    Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer
- Review, Var, NA
Inflam↓, TumCCA↑, Casp3↑, Casp8↑, Casp9↑, STAT3↑, SHP1↓, NF-kB↓, cycD1/CCND1↓, COX2↓, Ki-67↓, CD31↓, IAP1↓, MMPs↓, Bcl-2↓, Bcl-xL↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Bcl-2↓, 1,   Bcl-xL↓, 1,   Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 1,   IAP1↓, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

SHP1↓, 1,   STAT3↑, 1,  

Migration ⓘ

CD31↓, 1,   Ki-67↓, 1,   MMPs↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   Inflam↓, 1,   NF-kB↓, 1,  

Clinical Biomarkers ⓘ

Ki-67↓, 1,  
Total Targets: 17

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: SHP1, Src Homology region 2 domain-containing Phosphatase-1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1331  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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