CYP1B1 Cancer Research Results

CYP1B1, Cytochrome P450 Family 1 Subfamily B Member 1: Click to Expand ⟱

Source:

Type:

CYP1B1 (Cytochrome P450 Family 1 Subfamily B Member 1) is a xenobiotic- and hormone-metabolizing enzyme involved in oxidative metabolism, particularly of estrogens and procarcinogens.
-overexpressed in cancer, with poor prognosis
-A striking feature of CYP1B1 is its consistent overexpression in many tumors with minimal expression in adjacent normal tissue.

CYP1B1 overactivity contributes to cancer by:
-Increasing DNA damage burden
-Promoting genomic instability
-Supporting hormone-driven proliferation
-Modulating local redox balance (Generates reactive oxygen species (ROS))

Scientific Papers found: Click to Expand⟱

6595-

Anamu,

Dibenzyl trisulfide binds to and competitively inhibits the cytochrome P450 1A1 active site without impacting the expression of aryl hydrocarbon receptor

in-vivo,

Nor,

zebrafish (Danio rerio) embryos were exposed to 0.08–0.8 μM DTS f

CYP1A1↓, CYP1B1↓, chemoPv↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

CYP1A1↓, 1,

DNA Damage & Repair ⓘ

CYP1B1↓, 1,

Functional Outcomes ⓘ

chemoPv↑, 1,
Total Targets: 3

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: CYP1B1, Cytochrome P450 Family 1 Subfamily B Member 1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells