CYP1B1 Cancer Research Results

CYP1B1, Cytochrome P450 Family 1 Subfamily B Member 1: Click to Expand ⟱
Source:
Type:
CYP1B1 (Cytochrome P450 Family 1 Subfamily B Member 1) is a xenobiotic- and hormone-metabolizing enzyme involved in oxidative metabolism, particularly of estrogens and procarcinogens.
-overexpressed in cancer, with poor prognosis
-A striking feature of CYP1B1 is its consistent overexpression in many tumors with minimal expression in adjacent normal tissue.
CYP1B1 overactivity contributes to cancer by:
-Increasing DNA damage burden
-Promoting genomic instability
-Supporting hormone-driven proliferation
-Modulating local redox balance (Generates reactive oxygen species (ROS))


Scientific Papers found: Click to Expand⟱
6595- Anamu,    Dibenzyl trisulfide binds to and competitively inhibits the cytochrome P450 1A1 active site without impacting the expression of aryl hydrocarbon receptor
- in-vivo, Nor, NA
CYP1A1↓, CYP1A1 and CYP1B1 bactosomes on a fluorogenic assay, we first demonstrated that DTS moderately inhibited both enzymes with half maximal inhibitory concentration (IC50) values of 1.3 ± 0.3 and 1.7 ± 0.3 μM,
CYP1B1↓,
chemoPv↑, these results demonstrate that DTS is a direct, reversible, competitive inhibitor of the carcinogen-activating CYP1A enzyme, binding in the active site pocket close to the heme site, and shows potential in chemoprevention.

7459- HNK,    Honokiol Exhibits Anti-Tumor Effects in Breast Cancer by Modulating the miR-148a-5p-CYP1B1 Axis
- in-vitro, BC, MDA-MB-231
TumCP↓, We found that HNK significantly inhibited proliferation and induced apoptosis on BC cell lines in a dose-dependent manner.
Apoptosis↓,
TumCMig↓, HNK treatment suppressed migration and colony formation and initiated the intrinsic apoptotic pathway specifically in MDA-MB-231 cells.
CYP1B1↓, miR-148a-5p expression was significantly up-regulated, whereas CYP1B1 expression was down-regulated following HNK treatment.
ChemoSen↑, strong synergistic effect between HNK and paclitaxel was observed in vitro.

7470- Hops,    Hops (Humulus lupulus) inhibits oxidative estrogen metabolism and estrogen-induced malignant transformation in human mammary epithelial cells (MCF-10A)
- NA, Nor, MCF10
*CYP1A1↓, Estrogen-induced expression of CYP450 1B1 and CYP450 1A1 was attenuated by the hops extract.
*CYP1B1↓,

7604- I3C,    Multifunctional aspects of the action of indole-3-carbinol as an antitumor agent
2/16-OHE1↑, shown that it induces CyP4501A1, increasing 2-hydroxylation of estrogens, leading to the protective 2-OHE1, and also decreases CyP1B1 sharply, inhibiting 4-hydroxylation of estradiol, thereby decreasing the formation of the carcinogenic 4-OHE1.
CYP1B1↓,
4-OHE1↓,
Apoptosis↑, indole-3-carbinol has been shown to have direct effects on apoptosis and cyclin D, resulting in blockage of the cell cycle.
cycD1/CCND1↓,
TumCCA↑,
AntiTum↑, In addition to its antitumor activity in animals, it has also been shown to be effective against HPV-mediated tumors in human patients


Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

2/16-OHE1↑, 1,   4-OHE1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

CYP1A1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Apoptosis↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

CYP1B1↓, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   TumCCA↑, 1,  

Migration(tgid=13) ⓘ

TumCMig↓, 1,   TumCP↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,   chemoPv↑, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

CYP1A1↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

CYP1B1↓, 1,  
Total Targets: 2

Scientific Paper Hit Count for: CYP1B1, Cytochrome P450 Family 1 Subfamily B Member 1
1 DTS(dibenzyl trisulphide) from Anamu
1 Honokiol
1 Hops (Humulus lupulus)
1 Indole-3-carbinol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1345  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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