Acetyl-CoA Cancer Research Results

Acetyl-CoA, Acetyl-CoA/AcCoA: Click to Expand ⟱
Source:
Type:
Acetyl-CoA: 
A small molecule, specifically a coenzyme.
-Central to metabolism, especially in:
-The citric acid cycle (Krebs cycle)
-Fatty acid synthesis
-Ketogenesis

It carries acetyl groups (2-carbon units) and delivers them to biochemical reactions.


Scientific Papers found: Click to Expand⟱
5792- CRMs,  HCA,  CUR,  EGCG,  GAR  Caloric restriction mimetics: natural/physiological pharmacological autophagy inducers
- Review, Nor, NA
*CRM↓, *Dose?, *AntiAge↑, *Acetyl-CoA↓, *SIRT1↑, *AMPK↑, *mTORC1↓, *AntiAge↑, chemoP↑,
6984- Form,    Formononetin suppresses colitis-associated colon cancer by targeting lipid synthesis and mTORC2/Akt signaling
- in-vitro, Colon, HCT116 - Review, IBD, RAW264.7
*Inflam↓, AntiCan↑, *NF-kB↓, *MAPK↓, *colonLen↑, TumCG↓, Apoptosis↑, LC3II↑, Beclin-1↑, cl‑Casp3↑, BAX↑, Bcl-2↓, IGF-1↓, ACLY↓, Acetyl-CoA↓, Fas↓, HSL/LIPE↓, ATGL/PNPLA2↓, FFA/NEFA↓, GSK‐3β↑, p‑mTOR↓, Rictor↓, p‑Akt↓, PDE3B↓, p‑PKA↓, p‑HSL/LIPE↑, TumAuto↑,
4284- RES,    Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex
- in-vitro, AD, HEK293 - NA, Stroke, NA - in-vivo, AD, NA
*p‑tau↓, *PP2A↑, *neuroP↑, *antiOx↑, COX2/PTGS2↓, *AntiAg↑, *SIRT1↑, *AMPK↑, *Acetyl-CoA↓, *FAO↑, *ADAM10↑, *BACE/β-secretase↓, *Aβ↓, *memory↑, *Inflam↓, *ROS↓,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ATGL/PNPLA2↓, 1,   FFA/NEFA↓, 1,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   PDE3B↓, 1,   Rictor↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Acetyl-CoA↓, 1,   ACLY↓, 1,  

Cell Death(tgid=5) ⓘ

p‑Akt↓, 1,   Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   cl‑Casp3↑, 1,   Fas↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↑, 1,   LC3II↑, 1,   TumAuto↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

GSK‐3β↑, 1,   IGF-1↓, 1,   p‑mTOR↓, 1,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

p‑PKA↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   chemoP↑, 1,  
Total Targets: 25

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

colonLen↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   ROS↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Acetyl-CoA↓, 2,   AMPK↑, 2,   CRM↓, 1,   FAO↑, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

MAPK↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTORC1↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 2,   NF-kB↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ADAM10↑, 1,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   BACE/β-secretase↓, 1,   PP2A↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose?, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   memory↑, 1,   neuroP↑, 1,  
Total Targets: 22

Scientific Paper Hit Count for: Acetyl-CoA, Acetyl-CoA/AcCoA
1 Calorie Restriction Mimetics
1 HydroxyCitric Acid
1 Curcumin
1 EGCG (Epigallocatechin Gallate)
1 Garcinol
1 Formononetin
1 Resveratrol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1348  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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