Bil Cancer Research Results

Bil, Bilirubin: Click to Expand ⟱
Source:
Type:
Bilirubin a yellow pigment formed by the breakdown of heme (from red blood cells), is traditionally known for its role in liver function and jaundice.
Bilirubin as an Antioxidant (Cancer Protection)
-Moderately elevated bilirubin levels are associated with reduced cancer risk
-Bilirubin or synthetic analogs (e.g. bilirubin nanoparticles) are being studied for, Cancer prevention, and Reducing chemo side effects via oxidative stress protection.

In contrast, very high bilirubin levels in patients often indicate:
-Liver metastasis or hepatocellular carcinoma (HCC)
Scientific Papers found: Click to Expand⟱
5883- CAR,    Safety and tolerability of carvacrol in healthy subjects: a phase I clinical study
- Trial, Nor, NA
*Dose↝, Subjects were randomly divided into two groups receiving 1 and 2 mg/kg/day carvacrol.
*HDL↓, There was significant reductions in high-density lipoprotein cholesterol (HDL), total bilirubin, amylase, iron, red blood cells (RBC) count, and HCT after one-month treatment with 2 mg/kg/day carvacrol
*Bil↓,
*Iron↓,
*toxicity↓, The results of this phase I study regarding carvacrol effects on healthy subjects, showed clinical safety and tolerability for this agent.

3844- Moringa,    Review of the Safety and Efficacy of Moringa oleifera
- Review, NA, NA
*antiOx↑, biological activities including antioxidant, tissue protective (liver, kidneys, heart, testes, and lungs), analgesic, antiulcer, antihypertensive, radioprotective, and immunomodulatory actions.
*RenoP↑,
*hepatoP↑,
*radioP↑, Two studies have shown that extracts of M. oleifera can provide radioprotection in mice.
*eff↑, leaves are widely used as a basic food because of their high nutrition content
*toxicity↓, authors concluded that consumption of M. oleifera leaves at doses of up to 2000 mg/kg were safe.
*ROS↓, Chumark et al. (2008) demonstrated the free radical scavenging ability of an aqueous extract of M. oleifera leaves in several in vitro systems, and also showed that the extract inhibited lipid peroxidation in both in vitro and ex vivo systems.
*lipid-P↓,
*DNAdam↓, inhibit oxidative damage to DNA
*Catalase↑, increased the antioxidant enzymes catalase and superoxide dismutase while decreasing lipid peroxidases
*SOD↑,
*GPx↑, increases in the antioxidant enzymes glutathione peroxidase, glutathione reductase, catalase, superoxide dismutase, and glutathione S‐transferase (Sreelatha and Padma, 2010).
*GSR↑,
*GSTs↑,
*AST↓, M. oleifera leaves protects against liver damage as demonstrated by reductions in tissue histopathology and serum activities of marker enzymes aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP)
*ALAT↓,
*ALP↓,
*Bil↓, extract decreased drug‐induced levels of AST, ALT, ALP, and bilirubin


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Bil↓, 2,   Catalase↑, 1,   GPx↑, 1,   GSR↑, 1,   GSTs↑, 1,   HDL↓, 1,   Iron↓, 1,   lipid-P↓, 1,   ROS↓, 1,   SOD↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   eff↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   Bil↓, 2,  

Functional Outcomes ⓘ

hepatoP↑, 1,   radioP↑, 1,   RenoP↑, 1,   toxicity↓, 2,  
Total Targets: 23

Scientific Paper Hit Count for: Bil, Bilirubin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1355  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

Home Page