cGAS–STING Cancer Research Results

cGAS–STING, GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING): Click to Expand ⟱
Source:
Type:
cGAS–STING pathway is primarily associated with neuroinflammation and neuronal damage.
-Studies show upregulated STING in microglia and astrocytes in AD models.
Scientific Papers found: Click to Expand⟱
7253- Gink,    Ginkgetin Alleviates Inflammation and Senescence by Targeting STING
*cGAS–STING↓, thereby inhibiting STING activation and signal transduction.
*Inflam↓, Accumulating evidence has revealed that Ginkgo extract possesses anti‐inflammatory[ 12 ] and anti‐oxidant[ 13 ] properties and is effective in treating aging‐related diseases.[ 14 , 15 , 16 , 17 , 18 , 19 ]
*antiOx↑,
*AntiAge↑,
*DNAdam↓, otably, Ginkgetin exhibits inhibitory activity against oxidation, inflammation, and DNA damage, all of which are major factors inducing senescence
*cellSen↓, Ginkgetin Alleviates Cellular Senescence and Improves Pathologies in Multiple Tissues of Aging Mice

4035- NAD,  VitB3,    NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING
- in-vitro, AD, NA
*Inflam↓, Treatment of AD mice with NR reduced neuroinflammation, attenuated DNA damage, and prevented cellular senescence.
*DNAdam↓,
*NLRP3↓, NR treatment also reduced NLRP3 inflammasome expression, DNA damage, apoptosis, and cellular senescence in the AD mouse brains.
*cGAS–STING↓, cGAS–STING elevation was observed in the AD mice and normalized by NR treatment


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

cellSen↓, 1,   Inflam↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

cGAS–STING↓, 2,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,  
Total Targets: 7

Scientific Paper Hit Count for: cGAS–STING, GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1370  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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