BloodF Cancer Research Results

BloodF, Blood Flow: Click to Expand ⟱
Source:
Type:
Blood Flow
Scientific Papers found: Click to Expand⟱
7428- CS,    Exploring the Cardiovascular Potential of Artichoke—A Comprehensive Review
- Review, Nor, NA
*BloodF↓, Although clinical studies indicate improvements in flow-mediated dilation, they report only modest reductions in blood pressure,
*BP↓,

7676- iod,    Antineoplastic effect of iodine in mammary cancer: participation of 6-iodolactone (6-IL) and peroxisome proliferator-activated receptors (PPAR)
- in-vivo, BC, NA
TumCP↓, Studies in mammary cancer demonstrated that moderately high concentrations of molecular iodine (I2) have a antiproliferative and apoptotic effect either in vivo as in vitro
Apoptosis↑,
Dose↝, Virgin Sprague-Dawley rats were treated with methyl-nitrosourea (MNU: single dose ip, 50 mg/Kg bw)
other↑, tumoral but not normal mammary tissue contained an elevated basal concentration of AA and significantly more AA-iodinated called 6-iodolactone (6-IL) after chronic I2 treatment.
BloodF↓, Tumors from I2-treated rats showed fewer cells positive to proliferating cell nuclear antigen, lower blood vessel density, as well as decreases in vascular endothelial growth factor, urokinase-type plasminogen activator, and PPAR type alpha (PPARα).
VEGF↓,
UroPA↓,
PPARα↓,
DR4↑, These same tumors showed increases in the cell death markers, TUNEL-positive cells (p < 0.05) and the enzyme caspase-3 (trend), as well as significant induction of PPAR type gamma (PPARγ).
Casp3↑,
PPARγ↑,
antiNeop↑, Together, these data demonstrate that the antineoplasic effect of iodine involves 6-IL formation and PPARγ induction.
Risk↓, Cancer incidence was 37.5% lower in I2-treated than in control rats, whereas the number of tumors per rat and latency were similar for all groups
6IL↑,


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

6IL↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

PPARα↓, 1,   PPARγ↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   Casp3↑, 1,   DR4↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,   UroPA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↓, 1,  

Functional Outcomes(tgid=23) ⓘ

antiNeop↑, 1,   Risk↓, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Clinical Biomarkers(tgid=22) ⓘ

BloodF↓, 1,   BP↓, 1,  
Total Targets: 2

Scientific Paper Hit Count for: BloodF, Blood Flow
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1374  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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