TRPC1 Cancer Research Results

TRPC1, Transient Receptor Potential Canonical 1: Click to Expand ⟱
Source:
Type:
TRPC1 is a calcium-permeable ion channel protein that regulates key signaling pathways in many cell types, with roles in physiology and disease (including cancer). 
TRPC1 is upregulated in several cancer types, including breast cancer.
Since it contributes to Ca²⁺ influx, its overexpression can enhance signaling pathways that drive:
 -Proliferation
 -Migration & invasion
 -Epithelial–mesenchymal transition (EMT)
 -Chemoresistance

Breast cancer cell lines
MCF-7 (ER⁺, luminal type)
-TRPC1 is expressed and contributes to store-operated calcium entry (SOCE).
-Silencing or inhibiting TRPC1 tends to reduce proliferation and increase sensitivity to apoptosis.
MDA-MB-231 (triple-negative, invasive type)
-TRPC1 is generally upregulated compared to non-tumorigenic breast epithelial cells (like MCF10A or HBL-100).
-Promotes migration and invasion through calcium-dependent activation of signaling pathways (e.g., NFAT, ERK, AKT).
-Knockdown reduces motility and metastatic potential in vitro.
HBL-100 (SV40-transformed, non-malignant reference)
-TRPC1 expression is lower than in true malignant lines like MDA-MB-231.
-Often used as a “control” to highlight that TRPC1 is upregulated during malignant transformation.


Scientific Papers found: Click to Expand⟱
6002- CGA,    Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials
- Review, Var, NA - Review, Diabetic, NA - Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *Inflam↓, *antiOx↑, *cardioP↑, *NRF2↑, *AMPK↑, *SOD↑, *Catalase↑, *GSH↑, *GPx↑, *ROS↓, *TNF-α↓, *IL6↓, *NF-kB↓, *COX2↓, *glucose↓, *TRPC1↓, *Ca+2↓, *HO-1↑, *NF-kB↓, *PPARα↝, *Hif1a↓, *JNK↓, *BP↓, *AntiDiabetic↑, *hepatoP↑, *TLR4↓, *NRF2↑, *Casp↓, *neuroP↑, *Aβ↓, *LDH↓, *MDA↓, *memory↑, *AChE↓, *eff↑, EMT↝, N-cadherin↓, E-cadherin↑, TumCCA↑, ROS↑, p‑P53↑, HO-1↑, NRF2↑, ChemoSen↑, mtDam↑, Casp3↑, Casp9↑, PARP↑, Bax:Bcl2↑, TumCG↓, cycD1/CCND1↓, cMyc↓, CDK2↓, mitResp↓, Glycolysis↓, Hif1a↓, PCNA↓, p‑GSK‐3β↓, VEGF↓, PI3K↓, Akt↓, mTOR↓, OS↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

HO-1↑, 1,   NRF2↑, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mitResp↓, 1,   mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↓, 1,   Glycolysis↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Bax:Bcl2↑, 1,   Casp3↑, 1,   Casp9↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p‑P53↑, 1,   PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   cycD1/CCND1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↝, 1,   p‑GSK‐3β↓, 1,   mTOR↓, 1,   PI3K↓, 1,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

E-cadherin↑, 1,   N-cadherin↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   VEGF↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,  

Functional Outcomes(tgid=23) ⓘ

OS↑, 1,  
Total Targets: 28

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 1,   HO-1↑, 1,   MDA↓, 1,   NRF2↑, 2,   ROS↓, 1,   SOD↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   glucose↓, 1,   LDH↓, 1,   PPARα↝, 1,  

Cell Death(tgid=5) ⓘ

Casp↓, 1,   JNK↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↓, 1,   TRPC1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   IL6↓, 1,   Inflam↓, 1,   NF-kB↓, 2,   TLR4↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BP↓, 1,   IL6↓, 1,   LDH↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   cardioP↑, 1,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 2,  
Total Targets: 35

Scientific Paper Hit Count for: TRPC1, Transient Receptor Potential Canonical 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1376  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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