AntiDiabetic Cancer Research Results

AntiDiabetic, AntiDiabetic: Click to Expand ⟱
Source:
Type:
AntiDiabetic
Scientific Papers found: Click to Expand⟱
6401- ANE,    Anethole and Its Role in Chronic Diseases
- Review, Var, NA - Review, PSA, NA
*BioAv↝, Pure anethole is a colorless to faintly yellow liquid at above 23 °C [10]. It is poorly soluble in water, is highly soluble in alcohol, and is miscible with ether and chloroform.
*other↝, Trans-anethole has a sweet herbaceous smooth odor profile [7] and a sweet taste, being more than 10 times sweeter than common sugar
eff↓, Ultraviolet (UV) light and visible (VIS) light, temperature, atmospheric oxygen, the prolonged storage significantly influence the chemical stability of anethole.
TNF-α↓, Figure 3
IL10↑,
CXCR4↓,
MMP2↓,
MMP9↓,
TIMP1↑,
NF-kB↓,
AP-1↓,
STAT↓,
JNK↓,
ERK↓,
MAPK↓,
PI3K↓,
Akt↓,
JAK↓,
*AntiDiabetic↓,
*neuroP↑, Anethole dithiolethione (Fig. 4), a synthetic analogue of anethole, has an attractive potential in the development of neuroprotective agents in Parkinson’s disease due to its multifaceted antioxidant activity coupled with inhibition of monoamine oxid
*Imm↑, immunomodulatory profile of anethole may offer promising alternative therapy to counteract the effects of cytotoxic chemotherapeutic agents
chemoP↑,
*AntiThr↑, Anethole as well as fennel essential oil exhibit antithrombotic properties which are linked to a broad spectrum antiplatelet activity,
*AntiAg↑,
*antiOx↑, anticataract activity through the inhibition of lens aldose reductase (IC 50 = 3.8 lg/mL) and antioxidant activity. It increases SOD and catalase activities and restores GSH levels in the sugar induced lens opacification
*SOD↑,
*GSH↑,
*Wound Healing↑, administration of pharmaceutical formulation with 20 % anethole twice daily for 15 days accelerates wound closure of injured tissue
chemoPv↑, Cancer chemoprevention activity of anethole dithiolethione may be related to the increase of intracellular glutathione, up-regulation of phase II detoxification enzymes such as glutathione-S-transferase, and inhibition of NF-kB signaling activation
*GSTs↑,
*NF-kB↓,

5419- ASTX,    Astaxanthin and other Nutrients from Haematococcus pluvialis—Multifunctional Applications
- Review, Nor, NA
*antiOx↑, extraction of astaxanthin and analysis of its antioxidant, anti-inflammatory, anti–diabetic and anticancer activities.
*Inflam↓,
*AntiDiabetic↓,
AntiCan↑,
*lipid-P↓, astaxanthin is more effective than β-carotene in the prevention of lipid peroxidation.
TumCP↓, Studies have reported that astaxanthin not only inhibits the proliferation of colon cancer cells but can also cause their apoptosis
Apoptosis↑,
TumCCA↑, Astaxanthin was included in the extract and was responsible for stopping the progression of the cell cycle and promoting the apoptosis [95].
*SOD↑, Astaxanthin also increased SOD activity and decreased PG-E2, LT-B4, NO, IL-8 and IFN- γ production [103,104,105].
*PGE2↓,
*NO↓,
*IL8↓,
*IFN-γ↓,
*cardioP↑, Astaxanthin has a cardiovascular protective effect in animals, but there is a lack of research supporting the therapeutic benefit of astaxanthin in atherosclerotic cardiovascular disease in humans.
*NF-kB↓, Oral supplementation with astaxanthin in rats after surgery decreased the expression of NF-KB and TNF-α,
*TNF-α↓,
*BioAv↑, Satisfactory astaxanthin bioavailability results were obtained with a daily astaxanthin dose of 40 mg/day.

6021- CGA,    Chlorogenic acid for cancer prevention and therapy: Current status on efficacy and mechanisms of action
- in-vitro, Var, NA
*hepatoP↑, CA possesses a wide range of pharmacological properties, such as hepatoprotective, antimicrobial, immunomodulatory, antioxidant, antidiabetic, and anticancer activities.
*Bacteria↓,
*Imm↑,
*antiOx↑,
*AntiDiabetic↓,
*AntiCan↑,
TumCCA↑, CA can exert anticancer activity by inhibiting the cell cycle, triggering apoptosis, and suppressing the proliferation of cancer cells.
Apoptosis↑,
TumCP↓,


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 2,   JNK↓, 1,   MAPK↓, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   PI3K↓, 1,   STAT↓, 1,  

Migration ⓘ

AP-1↓, 1,   MMP2↓, 1,   MMP9↓, 1,   TIMP1↑, 1,   TumCP↓, 2,  

Immune & Inflammatory Signaling ⓘ

CXCR4↓, 1,   IL10↑, 1,   JAK↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   chemoP↑, 1,   chemoPv↑, 1,  
Total Targets: 22

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 3,   GSH↑, 1,   GSTs↑, 1,   lipid-P↓, 1,   SOD↑, 2,  

Transcription & Epigenetics ⓘ

AntiThr↑, 1,   other↝, 1,  

Migration ⓘ

AntiAg↑, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling ⓘ

IFN-γ↓, 1,   IL8↓, 1,   Imm↑, 2,   Inflam↓, 1,   NF-kB↓, 2,   PGE2↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   BioAv↝, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   AntiDiabetic↓, 3,   cardioP↑, 1,   hepatoP↑, 1,   neuroP↑, 1,   Wound Healing↑, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 25

Scientific Paper Hit Count for: AntiDiabetic, AntiDiabetic
1 Anethole/trans-Anethole
1 Astaxanthin
1 Chlorogenic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1385  State#:%  Dir#:1
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