VDAC1 Cancer Research Results

VDAC1, Voltage-Dependent Anion Channel 1: Click to Expand ⟱
Source:
Type:
VDAC1 is a pore-forming protein in the outer mitochondrial membrane that regulates metabolite flux (ATP/ADP, ions), mitochondrial–cytosolic communication, and apoptosis signaling. In Alzheimer’s disease, VDAC1 sits at a convergence point between mitochondrial dysfunction, oxidative stress, and neuronal death, all core features of AD pathophysiology.
-Upregulated VDAC1 detected in AD post-mortem cortex and hippocampus.
Scientific Papers found: Click to Expand⟱
4862- Uro,    Neuroprotective effect of Urolithin A via downregulating VDAC1-mediated autophagy in Alzheimer's disease
- in-vivo, AD, NA - in-vitro, Nor, PC12
*cognitive↑, UA improved cognitive dysfunction and reduced Aβ deposition in APP/PS1 mice
*p‑PI3K↓, UA down-regulated the phosphorylation level of PI3K/AKT/mTOR and up-regulated the phosphorylation level of AMPK
*p‑Akt↓,
*AMPK↑,
*VDAC1↓, UA down-regulated VDAC1
*neuroP↑, These findings demonstrated that UA down-regulated VDAC1 played a key neuroprotective role on AD by inhibiting the PI3K/AKT/mTOR pathway and activating the AMPK pathway to promote autophagy.
*PARK2↑, Mechanistically, UA may increase the expression of Parkin (Parkinson’s disease related-1) and PINK1 (PTEN induced kinase 1), and the LC3BII/I
*PTEN↑,
*LC3‑Ⅱ/LC3‑Ⅰ↑,
*p62↓, by inhibiting VDAC1, and reduce the expression level of p62, activating autophagy.
*Aβ↓, UA treatment significantly decreased the number of Aβ plaques in the hippocampus of APP/PS1 mice compared with APP/PS1 mice
*Apoptosis↓, UA inhibits Aβ-induced apoptosis and promotes autophagy


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

PARK2↑, 1,   VDAC1↓, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   Apoptosis↓, 1,  

Autophagy & Lysosomes ⓘ

LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   p62↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑PI3K↓, 1,   PTEN↑, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Functional Outcomes ⓘ

cognitive↑, 1,   neuroP↑, 1,  
Total Targets: 12

Scientific Paper Hit Count for: VDAC1, Voltage-Dependent Anion Channel 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1405  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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