DNMT3B Cancer Research Results

DNMT3B, Maintenance DNA Methyltransferase: Click to Expand ⟱
Source:
Type: oncogenic
DNMT3B 
Often UPREGULATED (mainly solid tumors)
Effect
-Aberrant de novo methylation at non-physiologic loci
-Silencing of differentiation and tumor suppressor genes
-Reinforces epigenetic chaos rather than orderly programming

Classification
-Contextual oncogenic epigenetic amplifier


Scientific Papers found: Click to Expand⟱
7007- Fuc,    The Therapeutic Potential of the Anticancer Activity of Fucoidan: Current Advances and Hurdles
- Review, Var, NA
TumCCA↑, Among the anticancer mechanisms of fucoidan are cell cycle arrest, apoptosis evocation, and stimulation of cytotoxic natural killer cells and macrophages.
Apoptosis↑,
NK cell↑,
chemoP↑, Fucoidan also protects against toxicity associated with chemotherapeutic drugs and radiation-induced damage.
TumCG↓, fucoidan slows tumor growth, kills cancer cells, and interacts with cancer chemotherapy drugs.
*Inflam↓, fucoidan has countless superior biological activities, which include anti-inflammatory, antioxidant, anticlotting, antithrombotic, antiviral, anti-angiogenesis, and anti-Helicobacter pylori activities
*antiOx↑,
*AntiThr↑,
*AntiViral↑,
angioG↓,
ChemoSen↑, Furthermore, LMWF complexed with tamoxifen, cisplatin, or paclitaxel shows cell growth inhibition, cellular apoptosis, and arrest of the cell cycle in the human breast cancer cell line MCF-7/ MDA-MB-231.
ROS↑, The study revealed that in breast cancer cells, phosphorylation of different proteins, elevation the reactive oxygen species (ROS) levels, and reduced glutathione (GSH) levels were all crucial in cancer cell apoptosis
GSH↓,
mtDam↓, reatment with fucoidan leads to increased levels of ROS in cells, along with mitochondrial damage and mitochondrial membrane potential (MMP) depolarization.
MMP↓,
DNMT3B↓, inhibition of its downstream target DNA methyltransferase 3B (DNMT3B) by the administration of a fixed dose of fucoidan
TumCG↓, Oral administration of fucoidan (5 mg/kg) effectively inhibited tumor growth in mice grown with B16 melanoma cells.
Dose↝, fucoidan (5 mg/kg) effectively inhibited tumor growth in mice
Dose↝, Twenty patients with advanced cancer were selected for the study, in which oral fucoidan (4 g daily) was administered for at least four weeks. After two consecutive weeks of ingestion, there was a significant reduction in the levels of key proinflamm
QoL∅, but no significant change was observed in patients’ quality of life, including the experience of fatigue
fatigue∅,
Dose↝, 300 mg fucoidan is safe and well tolerated by humans

7102- GEN,    Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits
- Review, Var, NA
*antiOx↑, reported in preclinical studies, such as the antioxidant, anti-inflammatory, antibacterial, and antiviral activities
*Inflam↓,
*Bacteria↓,
*AntiViral↑,
*Dose↝, the most genistein-rich foods are those fermented (miso and natto), which contain 38.5-230 μg/g of genistein, due to the β-glycosyl bond cleavage of genistin (7-O-β-D-glucoside form of genistein, naturally occurring in plants) by microbes during the
*AntiDiabetic↑, figure 1
angioG↑, In the low concentration (0.001–1 μM), genistein induced angiogenesis by promoted tube formation.
Apoptosis↑, Neuroblastoma IMR-32 SK-N-BE2 ↑Apoptosis, ↓cell viability, ↑Myd88, ↑Beclin 1, ↑LC3 II, ↑TLR4, ↑autophagy, ↓mTOR, ↓p62
tumCV↓,
MyD88↑,
Beclin-1↑,
LC3II↑,
TLR4↑,
TumAuto↑,
mTOR↓,
p62↓,
TumCCA↑, SK-N-SH ↑Cell cycle arrest at phase G2/M, ↓proliferation, ↑Akt, ↑CHD5, ↑p53, ↓neuroblastoma growth, ↓tumor microvessel formation, ↓DNMT3b, ↑ERE, ↑luciferase, ↑MEK
TumCP↓,
Akt↑,
P53↑,
DNMT3B↓,
MEK↓,
hTERT/TERT↓, ↓hTERT, ↓VEGF, ↓NF-κB, ↓c-IAP2, ↓MDR, ↓N-Myc, ↓FGF2, ↓p-Ak
VEGF↓,
NF-kB↓,
IAP1↓,
MDR1↓,
p‑Akt↓,
eff↑, There is synergistic efficiency of genistein and sorafenib (SF) combined treatment in human malignant neuroblastoma SH-SY5Y (
ChemoSen↑, Genistein has no special effect on P-gp function, but it boosts up the intracellular accumulation of doxorubicin

7654- IP,    Dietary Supplementation of Inulin Contributes to the Prevention of Estrogen Receptor-Negative Mammary Cancer by Alteration of Gut Microbial Communities and Epigenetic Regulations
- in-vivo, BC, NA
TumCG↓, Inulin supplementation greatly inhibited tumor growth and significantly delayed tumor latency.
GutMicro↑, The mice that consumed inulin had a distinct microbiome and higher diversity of gut microbial composition compared to the control.
PA↑, The concentration of propionic acid in plasma was significantly higher in the inulin-supplemented group.
HDAC2↓, The protein expression of epigenetic-modulating histone deacetylase 2 (Hdac2), Hdac8, and DNA methyltransferase 3b decreased.
HDAC8↓,
DNMT3B↓,
Akt↓, protein expression of factors related to tumor cell proliferation and survival, such as Akt, phospho-PI3K, and NF-kB, also decreased with inulin administration.
PI3K↓,
NF-kB↓,
Dose↝, This study explored the cancer prevention effect of 8%, 10%, and 15% inulin-supplemented diets (IN) on ER-negative mammary tumor development.
Dose↝, previous publications whereby 8% inulin (40 g fiber/day) was proven to be physiologically reasonable for treating human patients


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

PA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

GSH↓, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MEK↓, 1,   MMP↓, 1,   mtDam↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Akt↑, 1,   p‑Akt↓, 1,   Apoptosis↑, 2,   hTERT/TERT↓, 1,   IAP1↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↑, 1,   LC3II↑, 1,   p62↓, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNMT3B↓, 3,   P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

HDAC2↓, 1,   HDAC8↓, 1,   mTOR↓, 1,   PI3K↓, 1,   TumCG↓, 3,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

MyD88↑, 1,   NF-kB↓, 2,   NK cell↑, 1,   TLR4↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 2,   Dose↝, 5,   eff↑, 1,   MDR1↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

GutMicro↑, 1,   hTERT/TERT↓, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoP↑, 1,   fatigue∅, 1,   QoL∅, 1,  
Total Targets: 42

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 2,   Bacteria↓, 1,  
Total Targets: 7

Scientific Paper Hit Count for: DNMT3B, Maintenance DNA Methyltransferase
1 Fucoidan
1 Genistein (soy isoflavone)
1 Inulin Prebiotic
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1409  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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