TLE1 Cancer Research Results

TLE1, Transducin-Like Enhancer of split 1: Click to Expand ⟱
Source:
Type:
TLE1 and Cancer — Transcriptional Corepressor, Lineage Marker, and Context-Dependent Biomarker

TLE1 encodes Transducin-Like Enhancer of split 1, a transcriptional corepressor in the Groucho/TLE family. TLE1 does not bind DNA directly; instead, it represses transcription by partnering with sequence-specific transcription factors.
-Expression is often UPREGULATED in certain cancers, but this does not mean TLE1 is oncogenic by itself
-TLE1 is one of the most useful immunohistochemical (IHC) markers in soft tissue pathology.


Scientific Papers found: Click to Expand⟱
4933- PEITC,    Phenethyl isothiocyanate inhibits metastasis potential of non-small cell lung cancer cells through FTO mediated TLE1 m6A modification
- vitro+vivo, Lung, H1299 - vitro+vivo, SCC, H226
AntiCan↓, Isothiocyanates (ITCs) are natural compounds and inhibit the tumorigenesis of various cancers.
TumCP↓, Our previous studies show that ITCs inhibit the proliferation and metastasis of non-small cell lung cancer (NSCLC) cells, and have synergistic effects with chemotherapy drugs
TumMeta↓,
ChemoSen↑,
tumCV↓, We showed that phenethyl isothiocyanate (PEITC) dose-dependently inhibited the cell viability of both NSCLC cell lines H1299 and H226 with IC50 values of 17.6 and 15.2 μM, respectively.
TumCI↓, Furthermore, PEITC dose-dependently inhibited the invasion and migration of H1299 and H226 cells.
TumCMig↓,
FTO↓, PEITC treatment dose-dependently increased m6A methylation levels and inhibited the expression of the m6A demethylase fat mass and obesity-associated protein (FTO) in H1299 and H226 cells
TLE1↓, Moreover, we showed that PEITC suppressed the migration of NSCLC cells by inhibiting TLE1 expression and downstream Akt/NF-κB pathway.
Akt↓,
NF-kB↓,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Akt↓, 1,  

Transcription & Epigenetics ⓘ

TLE1↓, 1,   tumCV↓, 1,  

Migration ⓘ

FTO↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   TumMeta↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,  

Functional Outcomes ⓘ

AntiCan↓, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: TLE1, Transducin-Like Enhancer of split 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1416  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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