ACTH Cancer Research Results

ACTH, Adrenocorticotropic hormone: Click to Expand ⟱
Source:
Type:
Adrenocorticotropic hormone (ACTH) is a peptide hormone produced physiologically by the pituitary that stimulates the adrenal cortex to secrete cortisol. Cortisol then feeds back to suppress ACTH.
Very high ACTH/cortisol → severe metabolic derangements (hypokalemia, infections, muscle wasting)
Scientific Papers found: Click to Expand⟱
5032- PTS,    Pterostilbene Decreases the Antioxidant Defenses of Aggressive Cancer Cells In Vivo: A Physiological Glucocorticoids- and Nrf2-Dependent Mechanism
- in-vivo, Melanoma, NA
TumCG↓, Intravenous administration of Pter decreased human melanoma growth in vivo
NRF2↓, and thereby downregulated the glucocorticoid receptor- and nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-dependent antioxidant defense system in growing melanomas.
GR↓,
BBB↑, Pter can cross the blood–brain barrier
ACTH↓, Pter inhibits ACTH production in AtT-20 cells
eff↑, combined Pter and GSH depletion treatment chemosensitizes melanoma cells and facilitates their complete elimination.


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

NRF2↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,  

Hormonal & Nuclear Receptors ⓘ

ACTH↓, 1,   GR↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ACTH, Adrenocorticotropic hormone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1420  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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