Leptin Cancer Research Results

Leptin, Leptin: Click to Expand ⟱
Source:
Type:
Leptin is an adipokine elevated in obesity.
Many tumors overexpress the leptin receptor (Ob-R), creating autocrine/paracrine signaling loops.
Leptin acts as a pro-oncogenic signal integrator, linking:
-Adiposity
-Inflammation
-Growth factor signaling
-Metabolic reprogramming

1.Circulating leptin (systemic)
-Upregulated in obesity, which strongly correlates with higher cancer risk and worse outcomes in several tumor types.
-This creates a permissive, pro-tumor systemic environment.
2.Tumor leptin receptor (Ob-R) expression
-Frequently upregulated in tumors (and tumor stroma), even when circulating leptin is only modestly elevated.
-Leads to hypersensitivity to leptin.
3.Autocrine/paracrine leptin production
-Many tumors produce leptin locally, independent of adipose tissue.
-Establishes a self-reinforcing growth loop.
4.Downstream leptin signaling
-Consistently upregulated:
  -JAK2 → STAT3
  -PI3K → AKT → mTOR
  -APK/ERK
  -NF-κB
-These pathways drive proliferation, survival, angiogenesis, EMT, and therapy resistance.


Scientific Papers found: Click to Expand⟱
5192- dietMet,    Intermittent methionine restriction reduces IGF‐1 levels and produces similar healthspan benefits to continuous methionine restriction
OS↑, A sustained state of methionine restriction (MR) dramatically extends the healthspan of several model organisms.
eff↝, we show for the first time that IMR produces similar beneficial metabolic effects to continuous MR,
IGF-1↓, like continuous MR, IMR confers beneficial changes in the plasma levels of the hormones IGF‐1, FGF‐21, leptin, and adiponectin.
adiP↑, Plasma levels of the energy‐regulating hormones adiponectin and leptin are increased and decreased, respectively, by continuous MR
Leptin↓,
Weight↓, both continuous MR and the IMR2 regimen resulted in animals remaining lean over the course of the experiment

5055- Ex,    Why exercise has a crucial role in cancer prevention, risk reduction and improved outcomes
- Review, Var, NA
OS↑, In 2008, a cohort study of breast cancer survivors identified that patients who consistently exercised for greater than 2.5 hours per week following diagnosis had a greater than 60% reduction in the risk of all deaths compared with patients who were
IGF-1↓, Table 1, IGF1 Decreased levels, IGFBP3 Increased levels
IGFBP3↑,
BRCA1↑, BRCA1 Increased expression
BRCA2↑, BRCA2 Increased expression
RAS↓, RAS family oncogenes Suppressed activity
P53↑, P53 Enhanced activity
HSPs↑, Heat shock proteins Enhanced activity
Leptin↓, Leptin Reduced activity
Irisin↓, Irisin Enhanced activity
Resistin↓, Resistin Reduced activity
NK cell↑, NK cells Enhanced activity
CRP↓, C-reactive protein, interleukin-6, TNFα Reduced activity
IL6↓,
TNF-α↓,
PGE1↓, Prostaglandins Reduced activity
COX2↓, Cox-2 Reduced activity
*GSH↑, Glutathione, Catalase and Superoxide dismutase Increased activity
*Catalase↑,
*SOD↑,
*monoA↑, Monoamines Higher levels
*EndoR↑, Endorphins Increased release
*testos↑, testosterone increases immediately after vigorous exercise in some but not all studies. lasting for 20–60 minutes post-exercise
ROS↑, Physical activity, especially if strenuous, produces reactive oxidative species (ROS)
QoL↑, Adverse cancer-related symptoms, which have been shown to be alleviated by exercise, include fatigue, muscle weakness, thromboembolism, weight gain, loss of bone density, quality of life (QOL), psychological distress, incontinence and sexual dysfunct
BMD↑, the rate of decline in BMD was significantly less in the resistance exercise group, with a greater benefit seen in the aerobic exercise group
BowelM↑, Exercise reduces bowel transit time and ameliorates constipation and its associated abdominal cramps


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis ⓘ

adiP↑, 1,  

Transcription & Epigenetics ⓘ

BowelM↑, 1,  

Protein Folding & ER Stress ⓘ

HSPs↑, 1,  

DNA Damage & Repair ⓘ

BRCA1↑, 1,   BRCA2↑, 1,   P53↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

IGF-1↓, 2,   IGFBP3↑, 1,   RAS↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   CRP↓, 1,   IL6↓, 1,   NK cell↑, 1,   PGE1↓, 1,   Resistin↓, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors ⓘ

Irisin↓, 1,   Leptin↓, 2,  

Drug Metabolism & Resistance ⓘ

eff↝, 1,  

Clinical Biomarkers ⓘ

BMD↑, 1,   BRCA1↑, 1,   CRP↓, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

OS↑, 2,   QoL↑, 1,   Weight↓, 1,  
Total Targets: 27

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 1,   GSH↑, 1,   SOD↑, 1,  

Synaptic & Neurotransmission ⓘ

EndoR↑, 1,   monoA↑, 1,  

Hormonal & Nuclear Receptors ⓘ

testos↑, 1,  
Total Targets: 6

Scientific Paper Hit Count for: Leptin, Leptin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1421  State#:%  Dir#:1
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