HOXB-AS1 Cancer Research Results

HOXB-AS1, HOXB cluster antisense RNA 1: Click to Expand ⟱
Source:
Type:
HOXB-AS1 (HOXB cluster antisense RNA 1) is a long non-coding RNA (lncRNA) transcribed from the HOXB genomic locus. It does not encode a protein but exerts regulatory control at transcriptional, post-transcriptional, and epigenetic levels. Accumulating evidence places HOXB-AS1 as a pro-oncogenic lncRNA in multiple solid and hematologic malignancies.
-Generally upregulated in tumors compared with adjacent normal tissue.
Scientific Papers found: Click to Expand⟱
5080- SSE,    Sodium Selenite Regulates the Proliferation and Apoptosis of Gastric Cancer Cells by Suppressing the Expression of LncRNA HOXB-AS1
- in-vitro, GC, HGC27 - in-vitro, GC, NCI-N87
AntiTum↑, The in vivo antitumor effect of sodium selenite on gastric carcinoma has been demonstrated.
HOXB-AS1↓, Na2SeO3 downregulated the expression of HOXB-AS1 in the human gastric cancer (HGC) cell lines, HGC-27, NCI-N87, and KATO III cells, while inhibiting their proliferation and invasion and inducing apoptosis.
TumCP↓,
TumCI↓,
Apoptosis↑,
BAD↓, the expression of apoptosis-related (Bad, Bcl-2, and cleaved-caspase-3) and invasion-related (MMP2, E-cadherin, and N-cadherin) proteins, indicating increased apoptosis and decreased invasion.
Bcl-2↓, f Bcl-2, MMP2, and N-cadherin proteins was significantly downregulated
cl‑Casp3↑,
MMP2↓,
E-cadherin↑,
N-cadherin↓,
ROS↑, Na2SeO3 can increase ROS levels and inhibit the NF-κB signaling pathway, effectively inhibiting the growth, metastasis, and inducing apoptosis of renal cell carcinoma both in vitro and in vivo [41]
NF-kB↓,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   BAD↓, 1,   Bcl-2↓, 1,   cl‑Casp3↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

HOXB-AS1↓, 1,  

Migration ⓘ

E-cadherin↑, 1,   MMP2↓, 1,   N-cadherin↓, 1,   TumCI↓, 1,   TumCP↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: HOXB-AS1, HOXB cluster antisense RNA 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1427  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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