CTSS Cancer Research Results

CTSS, Cathepsin S: Click to Expand ⟱
Source:
Type:
CTSS — Cathepsin S

Primary role: Cysteine protease active at neutral pH; mediator of antigen processing and immune modulation.

Cancer relevance:
CTSS functions both lysosomally and extracellularly, particularly in tumor cells, antigen-presenting cells, and stromal compartments. It alters MHC class II antigen processing, promotes immune evasion, and contributes to angiogenesis and invasion. Unlike other cathepsins, CTSS remains active outside acidic lysosomes, amplifying its effects in the tumor microenvironment.

Net effect in established cancer:
Predominantly pro-tumor, through immune suppression, invasion, and resistance to immunotherapy.
Scientific Papers found: Click to Expand⟱
5124- Sal,    Inhibition of the autophagic flux by salinomycin in breast cancer stem-like/progenitor cells interferes with their maintenance
- in-vitro, BC, NA
CSCs↓, Salinomycin (Sal), a K+/H+ ionophore, has recently been shown to be at least 100 times more effective than paclitaxel in reducing the proportion of breast CSCs
LC3II↑, Sal-induced accumulation of LC3-II
other↓, Sal inhibits autophagy flux
lysosome↓, Sal treatment inhibits lysosomal activity
CTSZ↓, The combined activity of cathepsins Z, B, L, and S was significantly lower in Sal–treated cells, as were the specific activities of CTSB and CTSL, indicating that Sal significantly inhibits the activity of cathepsins
CTSB↓,
CTSL↓,
CTSS↓,
autoF↓, Inhibition of the autophagic flux by salinomycin
TumAuto↓, In this study, we reported the inhibitory effect of Sal on autophagy and its consequence on the crosstalk with the apoptosis pathway.


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Transcription & Epigenetics ⓘ

other↓, 1,  

Autophagy & Lysosomes ⓘ

autoF↓, 1,   LC3II↑, 1,   lysosome↓, 1,   TumAuto↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   CTSB↓, 1,   CTSL↓, 1,   CTSS↓, 1,  

Immune & Inflammatory Signaling ⓘ

CTSZ↓, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CTSS, Cathepsin S
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1432  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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