fatigue Cancer Research Results

fatigue, fatigue: Click to Expand ⟱
Source:
Type:
fatigue
Scientific Papers found: Click to Expand⟱
5435- AG,    Efficacy of Astragalus Membranaceus (Huang Qi) for Cancer-Related Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Studies
- Review, Var, NA
fatigue↓, meta-analysis showed that the addition of Astragalus membranaceus to the control group was effective in reducing cancer-related fatigue
QoL↑, The current evidence is supportive of the efficacy of Astragalus membranaceus in patients with cancer-related fatigue and their quality of life,
Dose↝, Wang et al. study 16 showed that both doses of 500 mg and 250 mg were effective in improving fatigue.

5324- ALC,    The anti-wasting effects of L-carnitine supplementation on cancer: experimental data and clinical studies
- Review, Var, NA
*cachexia↓, The results of this process favored L-carnitine supplementation in patients with cancer-related cachexia.
*Apoptosis↓, inhibiting apoptosis or reversing inflammatory processes.
*Inflam↓,
QoL↑, This treatment increased plasma-free carnitine concentrations and significantly improved fatigue, which was assessed using the functional assessment of cancer therapy, fatigue, and quality of life questionnaire, as well as quality-of-life measu
Dose↝, placebo-controlled trial, in which 2 g per day of LC was administrated orally for four weeks among eligible patients.
Weight↑, advanced pancreatic cancer received either LC (4 g/day orally) or a placebo for 12 weeks. The results showed that body mass index, nutritional status (body cell mass and body fat), and quality-of-life parameters increased
OS↝, There was an insignificant increase in overall survival, a decline in length of hospital stays, and decrease in fatigue among the LC-treated patients.
fatigue↓,
eff↝, some dietary factors, such as food intake restriction and intake of LC and certain micronutrients (vitamin C, vitamin B6, and iron, which are required as cofactors for endogenous LC biosynthesis) may have some effects on the efficacy of LC sup

5319- ALC,    l-carnitine and cancer cachexia: Clinical and experimental aspects
- Review, Var, NA
fatigue↓, carnitine supplementation has been tested in preliminary studies concerning human cachexia, resulting in improved fatigue and quality of life.
QoL↑,
*GSH↑, l-carnitine treatment improved the tumor-induced decrease in muscular glutamate and glutathione levels and the increased plasma glutamate levels in tumor-bearing rodents
Dose↝, Significant improvements in fatigue were also observed in a randomized phase III clinical trial, in which l-carnitine (4 g/day) was orally given to patients with advanced cancer

5474- BM,    Pharmacological attributes of Bacopa monnieri extract: Current updates and clinical manifestation
*memory↑, Bacopa monnieri has been used for centuries in Ayurvedic medicine, alone or in combination with other herbs, as a memory and learning enhancer, sedative, and anti-epileptic.
*neuroP↑, Brahmi as a lead formulation for treating neurological disorders and exerting cognitive-enhancing effects.
*cognitive↑,
*hepatoP↑, figure 1
*antiOx↑,
*AntiDiabetic↑,
*fatigue↓,
*GSK‐3β↓, figure 3
*PI3K↑,
*Akt↑,
*tau↓,
*ROS↓, The neuroprotective properties of these bioactive components include reduction of ROS, neuroinflammation, aggregation inhibition of amyloid-β and improvement of cognitive and learning behavior.
*Inflam↓,

5918- Cats,    Uncaria tomentosa (cat's claw) improves quality of life in patients with advanced solid tumors
- Trial, Var, NA
Dose↝, 100-mg dose of a dry extract of U. tomentosa three times per day in patients with advanced solid tumors
QoL↑, Treatment improved the patients' overall quality of life (p=0.0411) and social functioning
fatigue↓, Use of cat's claw might be beneficial in patients with advanced cancer by improving their quality of life and reducing fatigue.


Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Drug Metabolism & Resistance ⓘ

Dose↝, 4,   eff↝, 1,  

Functional Outcomes ⓘ

fatigue↓, 4,   OS↝, 1,   QoL↑, 4,   Weight↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   GSH↑, 1,   ROS↓, 1,  

Cell Death ⓘ

Akt↑, 1,   Apoptosis↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

GSK‐3β↓, 1,   PI3K↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 2,  

Synaptic & Neurotransmission ⓘ

tau↓, 1,  

Functional Outcomes ⓘ

AntiDiabetic↑, 1,   cachexia↓, 1,   cognitive↑, 1,   fatigue↓, 1,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 1,  
Total Targets: 16

Scientific Paper Hit Count for: fatigue, fatigue
2 Acetyl-l-carnitine
1 Astragalus
1 Bacopa monnieri
1 Cat’s Claw
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1446  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

Home Page