Temp Cancer Research Results

Temp, Temperature: Click to Expand ⟱
Source:
Type:
Temperature
Scientific Papers found: Click to Expand⟱
5489- EP,    Electroporation and cell killing by milli- to nanosecond pulses and avoiding neuromuscular stimulation in cancer ablation
- in-vitro, Colon, NA
eff↑, The minimum fourfold ratio of cell killing and stimulation thresholds was achieved with bipolar nanosecond PEF (nsPEF)
TumCD↑,
MusCon↓, Restricting such bursts to the refractory period after nerve excitation will minimize the number of neuromuscular reactions while maintaining the ablation efficiency and avoiding heating.
Temp↓,
eff↑, It has long been known that nerve stimulation efficiency of short duration PEF can be further reduced by switching the pulse polarity
eff↓, However, bipolar nsPEF are also less efficient at electroporation and cell killing
eff↑, Applying nsPEF at low repetition rates or splitting pulse trains into short bursts with long intervals alleviates the concerns for concurrent thermal effects and may have an additional benefit of ablation with fewer pulses, by inducing electrosensiti
eff∅, The repetition rate had weak if any effect on the efficiency of unipolar pulses (Fig. 13A)
other↑, The experiments prove a strong and unambiguous advantage of ablation with nsPEF over “classic” IRE


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

TumCD↑, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,  

Cellular Microenvironment ⓘ

Temp↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↓, 1,   eff↑, 3,   eff∅, 1,  

Functional Outcomes ⓘ

MusCon↓, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Temp, Temperature
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1449  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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