MusCon Cancer Research Results

MusCon, Muscle Contraction: Click to Expand ⟱
Source:
Type:
Muscle Contraction
Scientific Papers found: Click to Expand⟱
5514- bemA,    Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients
- Trial, Nor, NA
*ACLY↓, Bempedoic acid, an ATP citrate lyase inhibitor, reduces low-density lipoprotein (LDL) cholesterol levels and is associated with a low incidence of muscle-related adverse events
*LDL↓, mean LDL cholesterol level at baseline was 139.0 mg per deciliter in both groups, and after 6 months, the reduction in the level was greater with bempedoic acid than with placebo by 29.2 mg per deciliter
*MusCon↓,
Dose↝, receive oral bempedoic acid, 180 mg daily, or placebo
cardioP↑, Among statin-intolerant patients, treatment with bempedoic acid was associated with a lower risk of major adverse cardiovascular events (death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, or coronary revascularization)

5488- EP,    An in vivo study of a custom-made high-frequency irreversible electroporation generator on different tissues for clinically relevant ablation zones
- in-vivo, Nor, NA
*MusCon↓, All H-FIRE protocols were able to generate visible ablation zones without muscle contractions, for both liver and kidney tissues
*Dose↓, bursts of bipolar pulses with much smaller pulse widths (0.25–50 μs).
*eff↑, demonstrated that the H-FIRE pulse waveforms at 4000 V/cm did not cause muscle contractions in a rat model, nor did they cause a significant temperature increase.
*Temp↝, generate negligible temperature increase (Δ⁢𝑇<1°C) during the whole pulse application procedure

5489- EP,    Electroporation and cell killing by milli- to nanosecond pulses and avoiding neuromuscular stimulation in cancer ablation
- in-vitro, Colon, NA
eff↑, The minimum fourfold ratio of cell killing and stimulation thresholds was achieved with bipolar nanosecond PEF (nsPEF)
TumCD↑,
MusCon↓, Restricting such bursts to the refractory period after nerve excitation will minimize the number of neuromuscular reactions while maintaining the ablation efficiency and avoiding heating.
Temp↓,
eff↑, It has long been known that nerve stimulation efficiency of short duration PEF can be further reduced by switching the pulse polarity
eff↓, However, bipolar nsPEF are also less efficient at electroporation and cell killing
eff↑, Applying nsPEF at low repetition rates or splitting pulse trains into short bursts with long intervals alleviates the concerns for concurrent thermal effects and may have an additional benefit of ablation with fewer pulses, by inducing electrosensiti
eff∅, The repetition rate had weak if any effect on the efficiency of unipolar pulses (Fig. 13A)
other↑, The experiments prove a strong and unambiguous advantage of ablation with nsPEF over “classic” IRE

5491- EP,    Nano-pulse stimulation™ therapy (NPS™) is superior to cryoablation in clearing murine melanoma tumors
- in-vivo, Melanoma, B16-F10
TumCD↑, Nano-Pulse Stimulation™ Therapy (NPS™) is a new, bioelectric modality that applies ultrashort pulses of electric energy to trigger regulated cell death in treated tissues.
eff↑, NPS permanently eliminated up to 91% of all tumor lesions with a single treatment compared to cryoablation that only eliminated up to 66%.
MusCon↓, with minimal dermal fibrosis, underlying muscle atrophy, permanent hair follicle loss or other markers of permanent skin damage.
CellMemb↑, NPS is a bioelectric energy modality that triggers the cell’s natural self-destruct pathway by initiating a transient permeabilization of the plasma and organelle membranes of targeted cells without causing thermal damage.
ER Stress↑, NPS is a bioelectric energy modality that triggers the cell’s natural self-destruct pathway by initiating a transient permeabilization of the plasma and organelle membranes of targeted cells without causing thermal damage.
other↝, The current lesion size limitation is 1 cm in diameter for a single treatment, but larger lesions can be treated with multiple applications


Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

TumCD↑, 2,  

Transcription & Epigenetics ⓘ

other↑, 1,   other↝, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,  

Barriers & Transport ⓘ

CellMemb↑, 1,  

Cellular Microenvironment ⓘ

Temp↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   eff↓, 1,   eff↑, 4,   eff∅, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   MusCon↓, 2,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


Core Metabolism/Glycolysis ⓘ

ACLY↓, 1,   LDL↓, 1,  

Cellular Microenvironment ⓘ

Temp↝, 1,  

Drug Metabolism & Resistance ⓘ

Dose↓, 1,   eff↑, 1,  

Functional Outcomes ⓘ

MusCon↓, 2,  
Total Targets: 6

Scientific Paper Hit Count for: MusCon, Muscle Contraction
3 Electrical Pulses
1 bempedoic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1450  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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