VGSC Cancer Research Results

VGSC, VGNC, Na+ voltage-gated channel: Click to Expand ⟱
Source:
Type:
Voltage-gated sodium channels (VGSCs or VGNCs) (Na+ voltage-gated channel)
-aberrant expression of VGSCs occurs in many cancers, where they contribute to invasion, metastasis, and tumor aggressiveness rather than electrical signaling.
-In most cancers studied to date, voltage-gated sodium channels (VGSCs) are upregulated and hyperactive compared with normal tissue.
-Blocking VGSCs consistently reduces metastasis behaviors
Scientific Papers found: Click to Expand⟱
5525- EP,    Cell responses without receptors and ligands, using nanosecond pulsed electric fields (nsPEFs)
- Review, Var, NA
CellMemb↑, Ca+2↑, ER Stress↑, ROS↑, MMP↓, VGCC↓, VGSC↓, Dose↝,
6381- Eug,    Biological Properties and Prospects for the Application of Eugenol—A Review
- Review, Var, NA
*eff↑, *BioAv↝, *BioAv↝, *BioAv↑, *antiOx↑, *AntiAg↑, *Inflam↓, *AntiBio↑, *MAOA↓, *neuroP↑, *ROS↓, *RNS↓, *eff↑, NF-kB↓, PGE2↓, COX2↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, tumCV↓, PI3K↓, Akt↓, MMPs↓, ChemoSen↑, ALDH↓, *Pain↓, *VGSC↓, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *5LO↓, *chemoPv↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 1,   PI3K↓, 1,   VGCC↓, 1,   VGSC↓, 1,  

Migration ⓘ

Ca+2↑, 1,   MMPs↓, 1,   TumCI↓, 1,   TumCMig↓, 1,  

Barriers & Transport ⓘ

CellMemb↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   NF-kB↓, 1,   PGE2↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   Dose↝, 1,  
Total Targets: 21

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

AntiBio↑, 1,  

Redox & Oxidative Stress ⓘ

antiOx↑, 1,   RNS↓, 1,   ROS↓, 1,  

Cell Death ⓘ

iNOS↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

VGSC↓, 1,  

Migration ⓘ

5LO↓, 1,   AntiAg↑, 1,  

Immune & Inflammatory Signaling ⓘ

IL1β↓, 1,   IL6↓, 1,   Inflam↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

MAOA↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   BioAv↝, 2,   eff↑, 2,  

Clinical Biomarkers ⓘ

IL6↓, 1,  

Functional Outcomes ⓘ

chemoPv↑, 1,   neuroP↑, 1,   Pain↓, 1,  
Total Targets: 20

Scientific Paper Hit Count for: VGSC, VGNC, Na+ voltage-gated channel
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1451  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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