VGSC Cancer Research Results

VGSC, VGNC, Na+ voltage-gated channel: Click to Expand ⟱
Source:
Type:
Voltage-gated sodium channels (VGSCs or VGNCs) (Na+ voltage-gated channel)
-aberrant expression of VGSCs occurs in many cancers, where they contribute to invasion, metastasis, and tumor aggressiveness rather than electrical signaling.
-In most cancers studied to date, voltage-gated sodium channels (VGSCs) are upregulated and hyperactive compared with normal tissue.
-Blocking VGSCs consistently reduces metastasis behaviors
Scientific Papers found: Click to Expand⟱
5525- EP,    Cell responses without receptors and ligands, using nanosecond pulsed electric fields (nsPEFs)
- Review, Var, NA
CellMemb↑, Over 30 years ago, electric fields were shown to transiently permeabilize plasma membranes and to introduce deoxyribonucleic acid (DNA) into cells by electroporation.
Ca+2↑, NsPEFs have been shown to breach intracellular granules,9 to mobilize Ca2+ from the ER and through plasma membranes,18–20 and to modulate intracellular Ca2+ levels in chromaffin cells
ER Stress↑,
ROS↑, NsPEFs induce calcium-dependent reactive oxygen species, which appear to require calcium entry through the plasma membrane pores.
MMP↓, NsPEFs also cause a rapid time- and electric field-dependent dissipation of the mitochondria membrane potential (∆Ψm).
VGCC↓, It has been shown that nsPEFs inhibit voltage-gated Na+ and Ca2+ channels,35
VGSC↓,
Dose↝, What seems clear is that when used at low repetition rates (1–2 Hz), nsPEF-induced cell death is not thermal nor immediate, but somewhat calculated and finally, default-driven.

6381- Eug,    Biological Properties and Prospects for the Application of Eugenol—A Review
- Review, Var, NA
*eff↑, Isoeugenol derivatives have become a popular subject of research due to their fungicidal and insecticidal properties, because they exhibit greater antimicrobial activity than eugenol
*BioAv↝, Eugenol is a clear to pale yellow liquid with an oily consistency and a spicy aroma. It is sparingly soluble in water and well soluble in organic solvents.
*BioAv↝, Eugenol has low chemical stability and is sensitive to oxidation and various chemical interactions. When orally administered, it is rapidly absorbed by various organs and metabolized in the liver.
*BioAv↑, encapsulation of eugenol seems to be the best solution to prevent early absorption, improve its water solubility, and, thus, increase its activity. eugenol delivered increases at least sixfold in infected cells when delivered as solid lipid NPs
*antiOx↑, Eugenol has demonstrated various antioxidant, analgesic, antimutagenic, anti-platelet, antiallergic, anti-swelling, and anti-inflammatory properties.
*AntiAg↑,
*Inflam↓,
*AntiBio↑, It has also displayed antimicrobial effects against many human pathogens, including a wide group of Gram-positive and Gram-negative bacteria and fungi and a number of parasites
*MAOA↓, Eugenol is a popular antioxidant and monoamine oxidase (MAO) inhibitor, and it is also known to exhibit neuroprotective properties
*neuroP↑,
*ROS↓, Eugenol is known to scavenge free radicals, inhibit the generation of reactive oxygen species, prevent the production of reactive forms of nitrogen
*RNS↓,
*eff↑, The study on eugenol showed that this compound has synergistic activity with various antibiotics, such as vancomycin, penicillin, ampicillin, and erythromycin, and the combination of these compounds allowed a reduction in MIC values of 5–1000 times
NF-kB↓, killing cancer cells. The molecular mechanism is believed to include various stages: inhibiting NF-κB activation, downregulating prostaglandin synthesis, reducing cyclooxygenase-2 activity,
PGE2↓,
COX2↓,
TumCCA↑, inducing cell cycle arrest in the S phase, and causing apoptotic cell death by lowering inflammatory cytokine levels
Apoptosis↑,
TumCMig↓, even a low dose of eugenol interfered with the migration and invasion of carcinogenic cells, inhibited lung cancer cell viability,
TumCI↓,
tumCV↓,
PI3K↓, blocking the PI3K/Akt pathway (an intracellular signaling pathway involved in cell cycle regulation) and inhibiting MMP (matrix metalloproteinase) activity
Akt↓,
MMPs↓,
ChemoSen↑, eugenol is believed to enhance the inhibition of breast cancer stem cells by cisplatin by inhibiting the activity of aldehyde dehydrogenases (ALDH)
ALDH↓,
*Pain↓, Eugenol is a popular painkiller and anesthetic used in dental practice.
*VGSC↓, It has been found to inhibit voltage-gated sodium channels (VGSC) in the primary supply neurons of the teeth in various studies, including one based on a rat model
*IL1β↓, It is also known to be an inhibitor of pro-inflammatory mediators, including IL-1β and IL-6, tumor necrosis factor alpha (TNF-α), prostaglandin E2 (PGE2), expression of inducible oxide nitrate synthase (iNOS)
*IL6↓,
*TNF-α↓,
*iNOS↓,
*5LO↓, nuclear factor kappa B (NF-κB), and leukotriene C4 and 5-lipoxygenase (5-LOX)
*chemoPv↑, eugenol dimers have shown chemopreventive properties by inhibiting cytokine expression in macrophages


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 1,   PI3K↓, 1,   VGCC↓, 1,   VGSC↓, 1,  

Migration ⓘ

Ca+2↑, 1,   MMPs↓, 1,   TumCI↓, 1,   TumCMig↓, 1,  

Barriers & Transport ⓘ

CellMemb↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   NF-kB↓, 1,   PGE2↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   Dose↝, 1,  
Total Targets: 21

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

AntiBio↑, 1,  

Redox & Oxidative Stress ⓘ

antiOx↑, 1,   RNS↓, 1,   ROS↓, 1,  

Cell Death ⓘ

iNOS↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

VGSC↓, 1,  

Migration ⓘ

5LO↓, 1,   AntiAg↑, 1,  

Immune & Inflammatory Signaling ⓘ

IL1β↓, 1,   IL6↓, 1,   Inflam↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

MAOA↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   BioAv↝, 2,   eff↑, 2,  

Clinical Biomarkers ⓘ

IL6↓, 1,  

Functional Outcomes ⓘ

chemoPv↑, 1,   neuroP↑, 1,   Pain↓, 1,  
Total Targets: 20

Scientific Paper Hit Count for: VGSC, VGNC, Na+ voltage-gated channel
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

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